Altered induction of the adaptive response to alkylation damage in Escherichia coli recF mutants.

Abstract:

:Escherichia coli recF mutants are hypermutable when treated with methyl methanesulfonate (G. C. Walker, Mol. Gen. Genet. 152:93-103, 1977). In this study, methylation hypermutability of recF mutant strains was examined, and it was found that recF+ is required for normal induction of the adaptive response to alkylation damage. Although this regulatory effect of recF mutations results in reduced levels of enzymes that specifically repair methyl lesions in DNA, it only partially explains the hypermutability. Further examination showed that methylation hypermutability of recF mutant strains required a functional umuDC operon, a component of the SOS response. These results lead to the hypothesis that methylation hypermutability results from the effects of recF mutations on the induction of both the SOS response and the adaptive response.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Volkert MR

doi

10.1128/jb.171.1.99-103.1989

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

99-103

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

171

pub_type

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