Abstract：
:Chronic tinnitus (ringing of the ears) is a medically untreatable condition that reduces quality of life for millions of individuals worldwide. Most cases are associated with hearing loss that may be detected by the audiogram or by more sensitive measures. Converging evidence from animal models and studies of human tinnitus sufferers indicates that, while cochlear damage is a trigger, most cases of tinnitus are not generated by irritative processes persisting in the cochlea but by changes that take place in central auditory pathways when auditory neurons lose their input from the ear. Forms of neural plasticity underlie these neural changes, which include increased spontaneous activity and neural gain in deafferented central auditory structures, increased synchronous activity in these structures, alterations in the tonotopic organization of auditory cortex, and changes in network behavior in nonauditory brain regions detected by functional imaging of individuals with tinnitus and corroborated by animal investigations. Research on the molecular mechanisms that underlie neural changes in tinnitus is in its infancy and represents a frontier for investigation.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Eggermont JJ,Roberts LEdoi
10.1007/s00441-014-1992-8subject
Has Abstractpub_date
2015-07-01 00:00:00pages
311-36issue
1eissn
0302-766Xissn
1432-0878journal_volume
361pub_type
杂志文章,评审abstract：:Previous immunochemical investigations have demonstrated various opioid peptides in the pancreas. However, controversies exist related to the cellular localization of these peptides in the endocrine pancreas. Therefore, the guinea pig endocrine pancreas was immunohistochemically investigated for the presence of opioid...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318454
更新日期：1990-02-01 00:00:00
abstract：:We previously described the presence of MHC class II (HLA-DR) antigens, structurally similar to those on lymphoid cells and bearing the genetically-appropriate allotypic determinants, on human adrenocortical cells in the zona reticularis of normal glands. We now report a similar expression by granulosa-lutein cells (G...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00309876
更新日期：1990-11-01 00:00:00
abstract：:Thy-1, a glycophosphatidylinositol-linked glycoprotein of the outer membrane leaflet, has been described in myofibroblasts of several organs. Previous studies have shown that, in fetal liver, Thy-1 is expressed in a subpopulation of ductular/progenitor cells. The aim of this study has been to investigate whether the l...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0437-z
更新日期：2007-09-01 00:00:00
abstract：:Thyroid hormone (TH) plays an important role in regulating ovarian development. However, the mechanism involved remains unclear. Evidence suggests that glucose is essential for ovarian development, and its uptake is mediated by several glucose transporter proteins (Glut). We have investigated the effects of TH on Glut...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2453-3
更新日期：2016-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-010-1049-6
更新日期：2011-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218867
更新日期：1989-12-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00306108
更新日期：1994-05-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215124
更新日期：1976-02-06 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410100418
更新日期：2001-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210353
更新日期：1981-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-019-03130-7
更新日期：2020-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2956-1
更新日期：2019-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00225806
更新日期：1988-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-010-0987-3
更新日期：2010-06-01 00:00:00
abstract：:Adult white-footed mice, Peromyscus leucopus, were kept either in long photoperiod (LP; LD 16:8) or in short photoperiod (SP; LD 8:16) for six weeks. Ovaries were serially sectioned and examined histologically. Preantral follicles were observed to release their oocyte into the ovarian stroma. This phenomenon is termed...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218373
更新日期：1982-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-020-03287-6
更新日期：2020-10-01 00:00:00
abstract：:Considerable evidence indicates that the state of ocular connective tissues and their response in glaucomatous disease affect the degree of glaucoma damage. Both experimental and clinical data suggest that improved diagnostic and prognostic information can be derived from the assessment of the mechanical responsivenes...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-013-1603-0
更新日期：2013-08-01 00:00:00
abstract：:The intestine, which is exposed to nutrition and to food-derived antigens and microbes including viruses and bacteria, might be an important site for the immune response. Crucial structural and functional differences exist between the small and large intestine, regional differences even having been demonstrated within...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-003-0706-4
更新日期：2003-07-01 00:00:00
abstract：:Urocortin (UCN) is a 40-amino-acid peptide and a member of the corticotropin-releasing hormone (CRH) family, which includes CRH, urotensin I, sauvagine, UCN2 and UCN3. The biological actions of CRH family peptides are mediated via two types of G-protein-coupled receptors, namely CRH type 1 receptor (CRHR1) and CRH typ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1450-4
更新日期：2012-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1720-9
更新日期：2014-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215191
更新日期：1986-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
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更新日期：2006-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1992-12-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03298-3
更新日期：2021-01-19 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00307790
更新日期：1995-05-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
abstract：:An increasingly pro-oxidant environment has been widely implicated in causing dysfunction of testicular steroidogenesis, but little progress has been made in understanding the underlying molecular mechanism. Here, we report that gamma-glutamyl transferase 5 (GGT5), a key metabolism component responsible for the cataly...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2458-y
更新日期：2016-11-01 00:00:00
abstract：:Communication between individuals is critical for species survival, reproduction, and expansion. Most terrestrial species, with the exception of humans who predominantly use vision and phonation to create their social network, rely on the detection and decoding of olfactory signals, which are widely known as pheromone...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-020-03376-6
更新日期：2021-01-12 00:00:00
abstract：:Neuropeptide F in invertebrates is a homolog of neuropeptide Y in mammals and it is a member of FMRFamide-related peptides. In arthropods, such as insects, there are two types of neuropeptide F comprising long neuropeptide F (NPF) and short neuropeptide F (sNPF). Both NPFs are known to play a crucial role in the regul...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-019-02999-8
更新日期：2019-06-01 00:00:00
abstract：:The effects of the administration of thyroxine (T4) on the postnatal cytodifferentiation of granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of Lewiss-Webster mice were studied by light and electron microscopy. From birth, mice of both sexes were injected daily with T4 (sc 0.4 micrograms/g BW) a...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218202
更新日期：1987-05-01 00:00:00
