Renal tight junction proteins are decreased in cisplatin-induced nephrotoxicity in rats.

abstract：:Methylglyoxal (MG) is a reactive dicarbonyl metabolite originated mainly from glucose degradation pathway that plays an important role in the pathogenesis of diabetes mellitus (DM). Reactions of MG with biological macromolecules (proteins, DNA and lipids) can induce cytotoxicity and apoptosis. Here, human erythrocytes...

journal_title：Toxicology mechanisms and methods

authors： Prestes AS,Dos Santos MM,Ecker A,Zanini D,Schetinger MR,Rosemberg DB,da Rocha JB,Barbosa NV

更新日期：2017-05-01 00:00:00

abstract：:The authors have previously shown that high alcohol preference rats (HAP) have a significantly higher sensitivity than low alcohol preference rats (LAP) for methamphetamine (MAP). In this study, changes in dopamine and serotonin release induced by MAP (1 mg/kg, intraperitoneally) after pre-treatment with D1 and D2 rec...

journal_title：Toxicology mechanisms and methods

authors： Nishiguchi M,Kinoshita H,Kasuda S,Takahashi M,Yamamura T,Matsui K,Ouchi H,Minami T,Hishida S,Nishio H

更新日期：2010-03-01 00:00:00

abstract：:The need for reliable results in Toxicological Analysis is recognized and required worldwide. The analytical validation ensures that a method will provide trustworthy information about a particular sample when applied in accordance with a predefined protocol, being able to determine a specific analyte at a distinct co...

journal_title：Toxicology mechanisms and methods

authors： Abrão LCC,Silveira AT,de Faria HD,Machado SC,Mendes TV,Plácido RV,Marciano LPA,Martins I

更新日期：2021-01-01 00:00:00

abstract：:In the present investigation acetylcholinesterase (AChE) was estimated in erythrocytes from blood samples exposed to four commonly used organophosphorus pesticides in vitro. The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitor...

journal_title：Toxicology mechanisms and methods

authors： Das GP,Jamil K,Rahman MF

更新日期：2006-01-01 00:00:00

abstract：:Prochloraz is a broad-spectrum contact imidazol fungicide used against several diseases in wheat, barley and oleaginous plants but also for treatment of flower production. Although prochloraz has endocrine disrupting and hepatocarcinogenic effects, there is lack of data on toxic effects of prochloraz. Therefore, we ai...

journal_title：Toxicology mechanisms and methods

authors： Alpertunga B,Kara M,Abudayyak M,Oztas E,Ozden S,Ozhan G

更新日期：2014-05-01 00:00:00

abstract：:Methylthiophanate is one of the widely used fungicides to control important fungal diseases of crops. The aim of this study was to elucidate the short-term hematoxicity and genotoxicity effects of methylthiophanate administered by intraperitoneal way at three doses (300, 500 and 700 mg/kg of body weight) after 24, 48 ...

journal_title：Toxicology mechanisms and methods

authors： Ben Amara I,Ben Saad H,Cherif B,Elwej A,Lassoued S,Kallel C,Zeghal N

更新日期：2014-12-01 00:00:00

abstract：:ABSTRACT The present investigation was undertaken to examine the effects of chlorpyrifos (CP, an organophosphate) and deltamethrin (DM, a pyrethroid pesticide) treatments at low and high doses and their combination on lipid peroxidation and antioxidant enzyme activities such as SOD, GSH-Px, and CAT and also AChE activ...

journal_title：Toxicology mechanisms and methods

authors： Tüzmen MN,Candan N,Kaya E

更新日期：2007-01-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNTs) have industrial applications in the nanotechnology field. The physico-chemical properties of MWCNTs vary greatly depending on MWCNT manufacture and application. It has been pointed out that their needle shape and high durability are important factors that determine the biopersist...

journal_title：Toxicology mechanisms and methods

authors： Fujita K,Obara S,Maru J,Endoh S

更新日期：2020-09-01 00:00:00

abstract：:The B6C3F1 mouse is the standard mouse strain used in National Toxicology Program (NTP) carcinogenesis studies. Over time, increased liver tumorigenesis that was correlated with elevated body weights was noted in males and females. NTP therefore replaced the NIH-07 diet with the NTP-2000 diet and returned to group hou...

journal_title：Toxicology mechanisms and methods

authors： Marino DJ

更新日期：2012-07-01 00:00:00

abstract：:The present study was designed for determining the exact mechanism of cytotoxic action of aluminum phosphide (AlP) in the presence of iron sucrose as the proposed antidote. Rats received AlP (12 mg/kg) and iron sucrose (5-30 mg/kg) in various sets and were connected to cardiovascular monitoring device. After identific...

journal_title：Toxicology mechanisms and methods

authors： Solgi R,Baghaei A,Golaghaei A,Hasani S,Baeeri M,Navaei M,Ostad SN,Hosseini R,Abdollahi M

更新日期：2015-01-01 00:00:00

abstract：:This study applied broccoli and cauliflower extracts (whole, floret, and stem) to zebrafish larvae in parallel to receive 100 mJ/cm(2) of UVB six times, and recorded their fin malformation phenotypes. Chemopreventive effects of each group, including UVB, whole-, floret-, and stem-extracts of broccoli and cauliflower o...

journal_title：Toxicology mechanisms and methods

authors： Chen YH,Wen CC,Lin CY,Chou CY,Yang ZS,Wang YH

更新日期：2011-01-01 00:00:00

abstract：:Dioxins and dioxin-like compounds (DLCs) are the ones with poor water solubility and low volatility, resistant to physical, chemical and biological processes, persistent in the environment even under extreme conditions. Due to lipophilic nature, they get adhered to the fatty material and concentrate through biomagnifi...

journal_title：Toxicology mechanisms and methods

authors： Khan MF,Alam MM,Verma G,Akhtar W,Rizvi MA,Ali A,Akhter M,Shaquiquzzaman M

更新日期：2017-02-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) is a highly toxic industrial solvent with pronounced systemic toxicity including brain. Neurotoxicity may be a direct result of hepatic dysfunction from CCl4 intoxication. Over the years CCl4 has been used as an excellent model for studying experimentally induced neurotoxicity in murine mod...

journal_title：Toxicology mechanisms and methods

authors： Naseem M,Parvez S

更新日期：2014-10-01 00:00:00

abstract：:Nematode Caenorhabditis elegans (C. elegans) was used to investigate the impact of silver nanoparticles (SNP), multiwalled carbon nanotubes (MWCNT), and polyamidoamine dendrimers (PAMAM) used in concentration of 1010 particle/mL. Population-based observations and gene expression analysis were employed in this study. S...

journal_title：Toxicology mechanisms and methods

authors： Walczynska M,Jakubowski W,Wasiak T,Kadziola K,Bartoszek N,Kotarba S,Siatkowska M,Komorowski P,Walkowiak B

更新日期：2018-07-01 00:00:00

abstract：:Fusarium mycotoxin toxicosis has been implicated in the etiology of Keshan disease, an endemic mitochondrial cardiomyopathy prevailing in certain areas of China. Butenolide (4-acetamido-4-hydroxy-2-butenoic acid gamma-lactone) is one of the Fusarium mycotoxins which are frequently detected from cereal grains in endemi...

journal_title：Toxicology mechanisms and methods

authors： Wang YM,Liu JB,Peng SQ

更新日期：2009-02-01 00:00:00

abstract：:This article described an improved brine shrimp larvae lethality microwell test method. A simply designed connecting vessel with alternative photoperiod was used to culture and collect high yield of active Artemia parthenogenetica nauplii for brine shrimp larvae lethality microwell test. Using this method, pure A. par...

journal_title：Toxicology mechanisms and methods

authors： Zhang Y,Mu J,Han J,Gu X

更新日期：2012-01-01 00:00:00

abstract：:Nicotine, an active substance present in tobacco has been identified as a major risk factor for lung related diseases. In the present study, we have evaluated the protective effect of curcumin on circulatory lipid peroxidation and antioxidants in nicotine administered Wistar rats. Lung toxicity was induced by subcutan...

journal_title：Toxicology mechanisms and methods

authors： Kalpana C,Menon VP

更新日期：2004-01-01 00:00:00

abstract：:To explore the toxic effect of T-2 toxin on mouse Leydig cells and its underlying molecular mechanisms, we isolated Leydig cells from mature mice, set-up Leydig cells culture, treated cells with T-2 toxin, evaluated cell proliferation, detected the caspase-3 activity, mitochondrial activity and apoptosis rate, and mea...

journal_title：Toxicology mechanisms and methods

authors： Zhang YF,Su PK,Wang LJ,Zheng HQ,Bai XF,Li P,Meng XP,Yang JY

更新日期：2018-01-01 00:00:00

abstract：:Crotonaldehyde is a ubiquitous hazardous pollutant, present in cigarette smoke and automobile exhaust and is endogenously generated by lipid peroxidation. Most of the current studies focus on its lung toxicity. However, there have been few investigations on the cardiac and renal toxicity caused by crotonaldehyde expos...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Li S,Men J,Peng C,Shao H,Zhang Z

更新日期：2019-05-01 00:00:00

abstract：:The titanium nitride coated titanium is a material intended for the fabrication of left ventricular assist device. As per International standards, a material is subjected to pre-clinical evaluation before fabrication of a device. Toxicity/biocompatibility studies such as acute systemic toxicity, intracutaneous irritat...

journal_title：Toxicology mechanisms and methods

authors： Geetha CS,Sabareeswaran A,Mohanan PV

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS:In this study, different concentrations of arsenic w...

journal_title：Toxicology mechanisms and methods

authors： Phan NN,Li KL,Lin YC

更新日期：2018-07-01 00:00:00

abstract：:This study was to evaluate the protective effects of Danshensu on liver injury induced by omethoate in Sprague Dawley rats. The acute omethoate poisoning model was established by administrating subcutaneously with omethoate at a single dose of 60 mg/kg. Danshensu treatment markedly inhibited the increases of aspartate...

journal_title：Toxicology mechanisms and methods

authors： Ren R,Wang T,Jiang N,Liu T,Du Y,Li C,Zhang L,Fu F

更新日期：2010-10-01 00:00:00

abstract：:The US military has placed major emphasis on developing therapeutics against nerve agents (NA). Current efforts are hindered by the lack of effective in vitro cellular models to aid in the preliminary screening of potential candidate drugs/antidotes. The development of an in vitro cellular model to aid in discovering ...

journal_title：Toxicology mechanisms and methods

authors： Kanjilal B,Keyser BM,Andres DK,Nealley E,Benton B,Melber AA,Andres JF,Letukas VA,Clark O,Ray R

更新日期：2014-10-01 00:00:00

abstract：:The present study was designed to investigate the effects of aqueous Azadirchta Indica leaf extract (AAILE) on serum glycoprotein contents and tumor incidence rate in colon of rats subjected to Dimethylhydrazine (DMH) treatment. Forty rats were divided equally and randomly into four groups viz., Group I (normal contro...

journal_title：Toxicology mechanisms and methods

authors： Ramzanighara A,Ezzatighadi F,Rai DV,Dhawan DK

更新日期：2009-05-01 00:00:00

abstract：:ABSTRACT Although copper is an essential metal and cadmium is an environmental pollutant, both are toxic when present in excess. Metallothionein and glutathione are two of the key components that participate in detoxification of copper and cadmium. In the present study the role of glutathione in resistance to copper a...

journal_title：Toxicology mechanisms and methods

authors： Bi WX,Kong F,Hu XY,Cui X

更新日期：2007-01-01 00:00:00

abstract：:Despite the increasing use of amorphous silica nanoparticles (SNPs) in biomedical applications, their toxicity after intravenous administration remains a major concern. We investigated the effects of single 7 mg/kg intravenous infusions of 13 nm SNPs on hemodynamic parameters in rats. Hematological and biochemical par...

journal_title：Toxicology mechanisms and methods

authors： Zhuravskii S,Yukina G,Kulikova O,Panevin A,Tomson V,Korolev D,Galagudza M

更新日期：2016-05-01 00:00:00

abstract：:Reported myocardial pathology resulting from increased levels of catecholamines in vivo has led us to investigate the effect of adrenalin on the gap junction proteins connexin 40 (Cx40) and Cx43 and the possible relationship to vascular toxicity. Adrenalin and its known metabolites, adrenochrome and adrenolutin, were ...

journal_title：Toxicology mechanisms and methods

authors： Moreau V,Novak MJ,Moore LK

更新日期：2006-01-01 00:00:00

abstract：CONTEXT:The critical role of CaMKIIδ isoforms in cardiac hypertrophy is well documented. OBJECTIVE:This study was aimed to investigate the possible inhibitory effects of aliskiren (ALS) and/or carvedilol (CAV) on CaMKIIδ isoforms expression in experimental cardiac hypertrophy. MATERIALS AND METHODS:Male Wistar albino...

journal_title：Toxicology mechanisms and methods

authors： Bin-Dayel AF,Abdel Baky NA,Fadda LM,Mohammad RA,Al-Mohanna F

更新日期：2016-02-01 00:00:00

abstract：:ABSTRACT This paper presents the results from an evaluation of the noncommercial, (quantitative) structure-activity relationship ([Q]SAR) models for the prediction of mutagenicity and carcinogenicity, carried out in a collaboration between the European Chemicals Bureau Group on Computational Toxicology and the Italian...

journal_title：Toxicology mechanisms and methods

authors： Benigni R,Bossa C

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The anatomical and histological parameters of the human ventricle depend on many factors including age and sex. Myocyte volume and electric capacitance are significant physiological parameters of left ventricle cardiomyocyte mathematical models. They allow the assessment of inter-individual variability durin...

journal_title：Toxicology mechanisms and methods

authors： Polak S,Fijorek K,Glinka A,Wisniowska B,Mendyk A

更新日期：2012-01-01 00:00:00