Hesperidin restores experimentally induced neurotoxicity in Wistar rats.

abstract：BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate genotoxicity and mutagenicity in peripheral blood and buccal mucosal cells in mucopolysaccharidosis (MPS) I, II or VI patients. METHODS:A total of 12 patients with MPS type I, II and VI attended at the Institute of Genetics and Inborn Errors of Metabolism...

journal_title：Toxicology mechanisms and methods

authors： Guilheiro JM,Chaves MD,Martins AM,Ribeiro DA,D'Almeida V

更新日期：2014-12-01 00:00:00

abstract：:Oxidative stress in biological systems can result in radical-induced lipid peroxidation (LPO), which can lead to the production of secondary reactive by-products such as 4-hydroxy-2-nonenal (HNE), malondialdehyde (MDA), acrolein, and acetaldehyde. These deleterious compounds are known to react with and concomitantly m...

journal_title：Toxicology mechanisms and methods

authors： Rainey RP,Gillman IG,Shi X,Cheng T,Stinson A,Gietl D,Albino AP

更新日期：2009-09-01 00:00:00

abstract：:The study aims at evaluating the combination of the quinocetone and the ML-7 in preclinical hepatocellular carcinoma models. To this end, the effect of quinocetone and ML-7 on apoptosis induction and signaling pathways was analyzed on HepG2 cell lines. Here, we report that ML-7, in a nontoxic concentration, sensitized...

journal_title：Toxicology mechanisms and methods

authors： Zhou Y,Zhang S,Deng S,Dai C,Tang S,Yang X,Li D,Zhao K,Xiao X

更新日期：2016-01-01 00:00:00

abstract：:ABSTRACT The present investigation was undertaken to examine the effects of chlorpyrifos (CP, an organophosphate) and deltamethrin (DM, a pyrethroid pesticide) treatments at low and high doses and their combination on lipid peroxidation and antioxidant enzyme activities such as SOD, GSH-Px, and CAT and also AChE activ...

journal_title：Toxicology mechanisms and methods

authors： Tüzmen MN,Candan N,Kaya E

更新日期：2007-01-01 00:00:00

abstract：:Reported myocardial pathology resulting from increased levels of catecholamines in vivo has led us to investigate the effect of adrenalin on the gap junction proteins connexin 40 (Cx40) and Cx43 and the possible relationship to vascular toxicity. Adrenalin and its known metabolites, adrenochrome and adrenolutin, were ...

journal_title：Toxicology mechanisms and methods

authors： Moreau V,Novak MJ,Moore LK

更新日期：2006-01-01 00:00:00

abstract：:During the last years, much attention was focused on the measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a marker of oxidative DNA damage. Among various analytical techniques, the (32)P-postlabeling assay has been applied in determination of 8-oxo-dG. However, artefactual DNA oxidation could take plac...

journal_title：Toxicology mechanisms and methods

authors： Maatouk I,Bouaïcha N,Plessis MJ,Périn F

更新日期：2006-01-01 00:00:00

abstract：:ABSTRACT Triptolide is a diterpene triepoxide isolated from the traditional Chinese medicinal vine Trypterygium wilfordii hook f. (T. wilfordii). It possesses multiple biological activities, such as antitumor, immunosuppression, and antifertility. Previous studies suggested that triptolide might be a potential candida...

journal_title：Toxicology mechanisms and methods

authors： Ni B,Zhu T,Jiang Z,Zhang R,Zhang T,Zhang L

更新日期：2008-01-01 00:00:00

abstract：:The US military has placed major emphasis on developing therapeutics against nerve agents (NA). Current efforts are hindered by the lack of effective in vitro cellular models to aid in the preliminary screening of potential candidate drugs/antidotes. The development of an in vitro cellular model to aid in discovering ...

journal_title：Toxicology mechanisms and methods

authors： Kanjilal B,Keyser BM,Andres DK,Nealley E,Benton B,Melber AA,Andres JF,Letukas VA,Clark O,Ray R

更新日期：2014-10-01 00:00:00

abstract：:The β-glucans (β-G) are polysaccharides produced by various organisms, and sulfation of β-G renders them more soluble. With the objective to assess the effects of sulfated and non-sulfated β-G extracted from Agaricus brasiliensis in MCF-7 cells, assays were used to evaluate cytotoxicity, genotoxicity, cell proliferati...

journal_title：Toxicology mechanisms and methods

authors： Baranoski A,Tempesta Oliveira M,Semprebon SC,Niwa AM,Ribeiro LR,Mantovani MS

更新日期：2015-01-01 00:00:00

abstract：:Xysmalobium undulatum (Uzara) is one of the most widely used indigenous traditional herbal remedies in Southern Africa. Commercially available Uzara plant material was used to prepare a crude aqueous extract, of which the toxicity potential was investigated in the hepatic HepG2/C3A cell line in both traditional two-di...

journal_title：Toxicology mechanisms and methods

authors： Calitz C,Hamman JH,Viljoen AM,Fey SJ,Wrzesinski K,Gouws C

更新日期：2018-11-01 00:00:00

abstract：:Concern over the influence of carbon nanotubes (CNTs) on human health has arisen due to advances; however, little is known about the potential toxicity of CNTs. In this study, impurity-free single-wall carbon nanotubes (SWCNTs), with different physical properties in cell culture medium, were prepared by a novel disper...

journal_title：Toxicology mechanisms and methods

authors： Fujita K,Fukuda M,Endoh S,Kato H,Maru J,Nakamura A,Uchino K,Shinohara N,Obara S,Nagano R,Horie M,Kinugasa S,Hashimoto H,Kishimoto A

更新日期：2013-10-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) activity is used widely as a biomarker for tumor promotion in animal model systems. Several previous studies have reported increases in ODC activity in tissues of rats exposed to 60 Hz magnetic fields. The goals of this study were to confirm these findings and to determine whether ODC act...

journal_title：Toxicology mechanisms and methods

authors： McDonald LJ,Loberg LI,McCormick DL,Gauger JR,Savage RE Jr,Zhu H,Lotz WG,Mandeville R,Owen RD,Cress LW,Desta AB

更新日期：2003-01-01 00:00:00

abstract：:Chlorine gas is one of the highly produced chemicals in the USA and around the world. Chlorine gas has several uses in water purification, sanitation, and industrial applications; however, it is a toxic inhalation hazard agent. Inhalation of chlorine gas, based on the concentration and duration of the exposure, causes...

journal_title：Toxicology mechanisms and methods

authors： Achanta S,Jordt SE

更新日期：2019-10-01 00:00:00

abstract：:ABSTRACT Dermal exposure to JP-8 petroleum jet fuel leads to toxicological responses in humans and rodents. Serum profiling is a molecular analysis of changes in the levels of serum proteins and other molecules in response to changes in physiology. This present study utilizes serum profiling approaches to examine biom...

journal_title：Toxicology mechanisms and methods

authors： Larabee JL,Hocker JR,Cheung JY,Gallucci RM,Hanas JS

更新日期：2008-01-01 00:00:00

abstract：CONTEXT:Over expression of renin-angiotensin system (RAS) and nuclear factor-kappaB (NF-κB) has a major role in many cancers. It has been suggested that some angiotensin receptor blockers (ARBs) could reduce the proliferation of cancer cells. The role of NF-κB pathway has been documented in cell proliferation. OBJECTI...

journal_title：Toxicology mechanisms and methods

authors： Bakhtiari E,Hosseini A,Boroushaki MT,Mousavi SH

更新日期：2015-01-01 00:00:00

abstract：:Ethanol metabolism induces generation of excessive amount of reactive oxygen species (ROS) which results in immune dysfunction. We examined the efficacy of silymarin on ethanol-induced oxidative stress, immunomodulatory activity, and vascular function in mice blood. Effectiveness of silymarin was compared with potent ...

journal_title：Toxicology mechanisms and methods

authors： Das SK,Mukherjee S

更新日期：2012-06-01 00:00:00

abstract：:To explore the toxic effect of T-2 toxin on mouse Leydig cells and its underlying molecular mechanisms, we isolated Leydig cells from mature mice, set-up Leydig cells culture, treated cells with T-2 toxin, evaluated cell proliferation, detected the caspase-3 activity, mitochondrial activity and apoptosis rate, and mea...

journal_title：Toxicology mechanisms and methods

authors： Zhang YF,Su PK,Wang LJ,Zheng HQ,Bai XF,Li P,Meng XP,Yang JY

更新日期：2018-01-01 00:00:00

abstract：:Silver and gold nanoparticles (Ag-AuNPs) are currently some of the most manufactured nanomaterials. Accordingly, the hazards associated with human exposure to Ag-AuNPs should be investigated to facilitate the risk assessment process. In particular, because pulmonary exposure to Ag-AuNPs occurs during handling of these...

journal_title：Toxicology mechanisms and methods

authors： Ávalos A,Haza AI,Mateo D,Morales P

更新日期：2015-01-01 00:00:00

abstract：:Miniscrew implants are widely used nowadays in orthodontic treatments due to their good results in clinical practice. However, data regarding the biocompatibility of commercially available orthodontic miniscrews and temporary devices are very scarce, and their role as genotoxicity inducers has been not previously eval...

journal_title：Toxicology mechanisms and methods

authors： Martín-Cameán A,Puerto M,Jos Á,Azqueta A,Iglesias-Linares A,Solano E,Cameán AM

更新日期：2015-01-01 00:00:00

abstract：:Angiogenesis, disturbance in redox homeostasis, and deregulated redox signaling are considered as common hallmarks of cancer progression and chemo resistance. In this context, PERK (protein kinase PKR-like ER kinase) branch of the unfolded protein response (UPR), an adaptive mechanism triggered by endoplasmic reticulu...

journal_title：Toxicology mechanisms and methods

authors： Sharma SH,Suresh Kumar J,Madhavan S,Nagarajan S

更新日期：2020-05-01 00:00:00

abstract：:Clinical use of doxorubicin continues to be challenged by its undesirable systematic toxicity, caused mainly by oxidative stress. The aim of this study was to investigate the effectiveness of fullerenol C(60)(OH)(24) polyanion nanoparticles, an antioxidant agent, against doxorubicin-induced nephro-, testicular, and pu...

journal_title：Toxicology mechanisms and methods

authors： Srdjenovic B,Milic-Torres V,Grujic N,Stankov K,Djordjevic A,Vasovic V

更新日期：2010-07-01 00:00:00

abstract：:The present study was designed to investigate the effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats. Sprague-Dawley rats were subcutaneously injected with isoproterenol (20 mg/kg). Cardiac marker enzymes in serum, antioxidative parameters and inflammatory...

journal_title：Toxicology mechanisms and methods

authors： Gai Y,Ma Z,Yu X,Qu S,Sui D

更新日期：2012-10-01 00:00:00

abstract：:Histone deacetylase 2 (HDAC2), a prominent member of the class I HDAC family, plays crucial roles in inflammation and other pathological processes. Recent studies have found that the activity and expression of HDAC2 were altered under oxidative stress conditions. The aim of the current study was to elucidate the expre...

journal_title：Toxicology mechanisms and methods

authors： Lu H,Wan J,Jiang R,Xie J,Peng X,Zhang L

更新日期：2012-10-01 00:00:00

abstract：:The brain is a well-organized, yet highly complex, organ in the mammalian system. Most investigators use the whole brain, instead of a selected brain region(s), for biochemical analytes as toxicological endpoints. As a result, the obtained data is often of limited value, since their significance is compromised due to ...

journal_title：Toxicology mechanisms and methods

authors： Gupta RC

更新日期：2004-01-01 00:00:00

abstract：:The objective of this study was to examine the toxicity of 1-(4-morpholinophenyl)-3-(4-fluorophenyl)-propenone (A) and 1-(4-morpholinophenyl)-3-(3-fluorophenyl)-propenone (B) on Spodoptera frugiperda (Sf9) cells and the mechanism of the toxicity. By cell-based thiazolyl blue tetrazolium bromide (MTT) assay, we found t...

journal_title：Toxicology mechanisms and methods

authors： Zhang X,Tao K,Hou T

更新日期：2012-05-01 00:00:00

abstract：:Abstract The effects of 4-hydroxytamoxifen (OHTAM) on the mitochondrial permeability transition (MPT) induced by Ca(2+) plus peroxynitrite (ONOO(-)) or phenylarsine oxide (PhAsO) were studied to clarify its mechanisms of MPT inhibition. Ca(2+) plus ONOO(-) induced mitochondrial swelling, membrane potential (Delta Psi)...

journal_title：Toxicology mechanisms and methods

authors： Cardoso CM,Almeida LM,Custódio JB

更新日期：2005-01-01 00:00:00

abstract：:For good performance in clinical and forensic toxicology, it is important to be aware of the signs and symptoms related to xenobiotic exposure since they will assist clinicians to reach a useful and rapid diagnosis. This manuscript highlights and critically analyses clinical and forensic imaging related to ethanol abu...

journal_title：Toxicology mechanisms and methods

authors： Dinis-Oliveira RJ,Magalhães T,Moreira R,Proença JB,Pontes H,Santos A,Duarte JA,Carvalho F

更新日期：2014-02-01 00:00:00

abstract：:We investigated the prooxidant effects of bisphenol A (BPA) phenoxyl radicals in comparison with the phenoxyl radicals of 3-tert-butyl-4-hydroxyanisole (BHA), 2,6-di-tert-butyl-methylphenol (BHT) and 4-tert-butylphenol (TBP). The phenoxyl radicals, generated in situ by 1-electron oxidation of the corresponding phenol,...

journal_title：Toxicology mechanisms and methods

authors： Babu S,Uppu S,Claville MO,Uppu RM

更新日期：2013-05-01 00:00:00

abstract：:In recent years, diabetes and its associated complications have come to represent a major public health concern. It is a complex disease characterized by multiple metabolic derangements and is known to impair cardiac function by disrupting the balance between pro-oxidants and antioxidants at the cellular level. The su...

journal_title：Toxicology mechanisms and methods

authors： Selvaraju V,Joshi M,Suresh S,Sanchez JA,Maulik N,Maulik G

更新日期：2012-06-01 00:00:00

abstract：:The present study was conducted to evaluate the sublethal effects of a synthetic pyrethroid, cypermethrin on ATPase, and glycogen phosphorylase in gill, kidney, liver, and muscle tissue of freshwater fish, Clarias batrachus (Linn) during exposure and cessation of exposure. Thirty-six fish were exposed to 1/3 of LC 50 ...

journal_title：Toxicology mechanisms and methods

authors： Begum G

更新日期：2009-01-01 00:00:00