Prooxidant actions of bisphenol A (BPA) phenoxyl radicals: implications to BPA-related oxidative stress and toxicity.

abstract：BACKGROUND:Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS:In this study, different concentrations of arsenic w...

journal_title：Toxicology mechanisms and methods

authors： Phan NN,Li KL,Lin YC

更新日期：2018-07-01 00:00:00

abstract：:Zinc (Zn) is one of the essential trace elements and has numerous physiological functions. Zn acts as an antioxidant and also as a part of other antioxidant related proteins, such as metallothionein (MT) and Zn-copper superoxide dismutase. Zn deficiency often occurs in patients with diabetes. Therefore, the effect of ...

journal_title：Toxicology mechanisms and methods

authors： Li B,Tan Y,Sun W,Fu Y,Miao L,Cai L

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The anatomical and histological parameters of the human ventricle depend on many factors including age and sex. Myocyte volume and electric capacitance are significant physiological parameters of left ventricle cardiomyocyte mathematical models. They allow the assessment of inter-individual variability durin...

journal_title：Toxicology mechanisms and methods

authors： Polak S,Fijorek K,Glinka A,Wisniowska B,Mendyk A

更新日期：2012-01-01 00:00:00

abstract：:The US military has placed major emphasis on developing therapeutics against nerve agents (NA). Current efforts are hindered by the lack of effective in vitro cellular models to aid in the preliminary screening of potential candidate drugs/antidotes. The development of an in vitro cellular model to aid in discovering ...

journal_title：Toxicology mechanisms and methods

authors： Kanjilal B,Keyser BM,Andres DK,Nealley E,Benton B,Melber AA,Andres JF,Letukas VA,Clark O,Ray R

更新日期：2014-10-01 00:00:00

abstract：:ABSTRACT Oxidative damage to cellular constituents is one of the major mechanisms of alcoholic liver injury, and administration of antioxidants ameliorates alcoholic liver disease. The present study investigated the influence of (-) epigallocatechin gallate (EGCG), a major polyphenol component of green tea, on oxidant...

journal_title：Toxicology mechanisms and methods

authors： Kaviarasan S,Sundarapandiyan R,Anuradha CV

更新日期：2008-01-01 00:00:00

abstract：:This report explores the direct counting of "hair-like" struc-tures specific for Gram-positive bacteria. Indications show that these structures are intact after removal from the cell and are sufficiently different from species to species of bacteria to give an indication of bacteria type if not actual identification. ...

journal_title：Toxicology mechanisms and methods

authors： Wick CH,Jabbour RE,McCubbin PE,Deshpande SV

更新日期：2006-01-01 00:00:00

abstract：:Hydroquinone (HQ), one of the most important metabolites derived from benzene, is known to be associated with acute myelogenous leukemia risk; however, its carcinogenic mechanism remains unclear. In a previous study, we found that low-level of benzene exposure down-regulated the expression of poly(ADP-ribose)polymeras...

journal_title：Toxicology mechanisms and methods

authors： Sha Y,Zhou W,Yang Z,Zhu X,Yang X,Li TD,Zhu D

更新日期：2015-01-01 00:00:00

abstract：:The aim of this work was to characterize inner mitochondrial membrane channels permeable to calcium cations (Ca(++)). Mitochondrial membranes isolated from rat heart were incorporated into the bilayer lipid membrane, and single Ca(++) channel currents were measured. The observed channels were selective for Ca(++) and ...

journal_title：Toxicology mechanisms and methods

authors： Komínková V,Novotová M,Ondrias K,Ravingerová T,Szewczyk A

更新日期：2004-01-01 00:00:00

abstract：:The advent of the industrial revolution has seen a significant increase in the number of new chemical entities (NCEs) released in the environment. It becomes imperative to check the toxic potential of NCEs to nontarget species before they are released for commercial purposes because some of these may exert genotoxicit...

journal_title：Toxicology mechanisms and methods

authors： Bajpayee M,Pandey AK,Parmar D,Dhawan A

更新日期：2005-01-01 00:00:00

abstract：:Oral cocaine administration results in hepatic necrosis, increased plasma transaminase concentration, and decreased antioxidative capability, which is potentiated by lipopolysaccharide (LPS) in male CF-1 mice. Females administered the same treatment regimen display none of the hepatotoxic effects seen in their male co...

journal_title：Toxicology mechanisms and methods

authors： Visalli T,Turkall R,Abdel-Rahman MS

更新日期：2005-01-01 00:00:00

abstract：:A potency of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) to reactivate cyclosarin-inhibited acetylcholinesterase and to reduce cyclosarin-induced acute toxic effects was evaluated in this study. In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue ac...

journal_title：Toxicology mechanisms and methods

authors： Kassa J,Karasova JZ,Musilek K,Kuca K

更新日期：2009-06-01 00:00:00

abstract：:Histone deacetylase 2 (HDAC2), a prominent member of the class I HDAC family, plays crucial roles in inflammation and other pathological processes. Recent studies have found that the activity and expression of HDAC2 were altered under oxidative stress conditions. The aim of the current study was to elucidate the expre...

journal_title：Toxicology mechanisms and methods

authors： Lu H,Wan J,Jiang R,Xie J,Peng X,Zhang L

更新日期：2012-10-01 00:00:00

abstract：:In pregnancy, opioids may be used medically and also misused. We hypothesized that the umbilical cord (UC) could be a good screening tool for determining opioid exposure and improving medical care. One hundred and one UC, each with 50 associated ICD9/ICD10 codes were used. Using predictive pharmacokinetic analysis we ...

journal_title：Toxicology mechanisms and methods

authors： Knight SJ,Smith AD,Wright TE,Collier AC

更新日期：2019-01-01 00:00:00

abstract：:Oxidative stress in biological systems can result in radical-induced lipid peroxidation (LPO), which can lead to the production of secondary reactive by-products such as 4-hydroxy-2-nonenal (HNE), malondialdehyde (MDA), acrolein, and acetaldehyde. These deleterious compounds are known to react with and concomitantly m...

journal_title：Toxicology mechanisms and methods

authors： Rainey RP,Gillman IG,Shi X,Cheng T,Stinson A,Gietl D,Albino AP

更新日期：2009-09-01 00:00:00

abstract：:A suboptimal in utero environment can have detrimental effects on the pregnancy and long-term adverse "programing" effects on the offspring. Aflatoxin B1 is one of the potent reproductive toxicants and currently detected in both milk and tissues. This article focuses on the effects of prenatal exposure to graded doses...

journal_title：Toxicology mechanisms and methods

authors： Supriya Ch,Akhila B,Pratap Reddy K,Girish BP,Sreenivasula Reddy P

更新日期：2016-01-01 00:00:00

abstract：:Dioxins and dioxin-like compounds (DLCs) are the ones with poor water solubility and low volatility, resistant to physical, chemical and biological processes, persistent in the environment even under extreme conditions. Due to lipophilic nature, they get adhered to the fatty material and concentrate through biomagnifi...

journal_title：Toxicology mechanisms and methods

authors： Khan MF,Alam MM,Verma G,Akhtar W,Rizvi MA,Ali A,Akhter M,Shaquiquzzaman M

更新日期：2017-02-01 00:00:00

abstract：:The present study was designed to investigate the effects of aqueous Azadirchta Indica leaf extract (AAILE) on serum glycoprotein contents and tumor incidence rate in colon of rats subjected to Dimethylhydrazine (DMH) treatment. Forty rats were divided equally and randomly into four groups viz., Group I (normal contro...

journal_title：Toxicology mechanisms and methods

authors： Ramzanighara A,Ezzatighadi F,Rai DV,Dhawan DK

更新日期：2009-05-01 00:00:00

abstract：:Due to their exceptional properties, gold nanoparticles (AuNPs) have shown promising medical and technological applications in the treatment of cancer and the development of antimicrobial packaging and time-temperature indicators in the food sector. However, little is known about their cytotoxicity when they come into...

journal_title：Toxicology mechanisms and methods

authors： Mateo D,Morales P,Ávalos A,Haza AI

更新日期：2014-03-01 00:00:00

abstract：:This study was to evaluate the protective effects of Danshensu on liver injury induced by omethoate in Sprague Dawley rats. The acute omethoate poisoning model was established by administrating subcutaneously with omethoate at a single dose of 60 mg/kg. Danshensu treatment markedly inhibited the increases of aspartate...

journal_title：Toxicology mechanisms and methods

authors： Ren R,Wang T,Jiang N,Liu T,Du Y,Li C,Zhang L,Fu F

更新日期：2010-10-01 00:00:00

abstract：:Reported myocardial pathology resulting from increased levels of catecholamines in vivo has led us to investigate the effect of adrenalin on the gap junction proteins connexin 40 (Cx40) and Cx43 and the possible relationship to vascular toxicity. Adrenalin and its known metabolites, adrenochrome and adrenolutin, were ...

journal_title：Toxicology mechanisms and methods

authors： Moreau V,Novak MJ,Moore LK

更新日期：2006-01-01 00:00:00

abstract：:Clinical use of doxorubicin continues to be challenged by its undesirable systematic toxicity, caused mainly by oxidative stress. The aim of this study was to investigate the effectiveness of fullerenol C(60)(OH)(24) polyanion nanoparticles, an antioxidant agent, against doxorubicin-induced nephro-, testicular, and pu...

journal_title：Toxicology mechanisms and methods

authors： Srdjenovic B,Milic-Torres V,Grujic N,Stankov K,Djordjevic A,Vasovic V

更新日期：2010-07-01 00:00:00

abstract：:The present study was designed to investigate the effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats. Sprague-Dawley rats were subcutaneously injected with isoproterenol (20 mg/kg). Cardiac marker enzymes in serum, antioxidative parameters and inflammatory...

journal_title：Toxicology mechanisms and methods

authors： Gai Y,Ma Z,Yu X,Qu S,Sui D

更新日期：2012-10-01 00:00:00

abstract：:Crotonaldehyde is a hazardous pollutant present in cigarette smoke and automobile exhausts that is generated by lipid peroxidation, and harmful to reproductive organs. Although we are often exposed to low doses of crotonaldehyde daily, its adverse effects on the reproductive organs have not been fully elucidated. To e...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Wei P,Men J,Zhang S,Shao H,Zhang Z

更新日期：2020-01-01 00:00:00

abstract：:ABSTRACT Ochratoxin A (OTA) and citrinin (CTN) are two mycotoxins, quite common contaminants, that can occur jointly in a wide range of food commodities. Both mycotoxins have several toxic effects but both share a significant nephrotoxic potential since OTA and CTN were reported to be responsible for naturally occurri...

journal_title：Toxicology mechanisms and methods

authors： Bouslimi A,Ouannes Z,Golli EE,Bouaziz C,Hassen W,Bacha H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The potential toxicity resulting from the possible interactions of the herbicides, Ultrazin (atrazine, ATZ) and Bretmont Wipeout (glyphosate, GLY) (as commercialized in Nigeria), is not completely known. We therefore evaluated reproductive- and hepato-toxicity in rats co-exposed to ATZ and GLY. METHODS:Six ...

journal_title：Toxicology mechanisms and methods

authors： Abarikwu SO,Akiri OF,Durojaiye MA,Adenike A

更新日期：2015-01-01 00:00:00

abstract：:ABSTRACT The present investigation was undertaken to examine the effects of chlorpyrifos (CP, an organophosphate) and deltamethrin (DM, a pyrethroid pesticide) treatments at low and high doses and their combination on lipid peroxidation and antioxidant enzyme activities such as SOD, GSH-Px, and CAT and also AChE activ...

journal_title：Toxicology mechanisms and methods

authors： Tüzmen MN,Candan N,Kaya E

更新日期：2007-01-01 00:00:00

abstract：:Tumor progression is the continual selection of variant subpopulations of malignant cells that have acquired increasing levels of genetic instability (Nowell Science 1976, 194, 23-28). This instability is manifested as chromosomal aneuploidy or translocations, viral integration or somatic mutations that typically affe...

journal_title：Toxicology mechanisms and methods

authors： Huppi K,Pitt J,Wahlberg B,Caplen NJ

更新日期：2011-05-01 00:00:00

abstract：:4-Methylimidazole (4-MeI) is a nitrogen-containing heterocyclic compound that is used in the manufacture of chemicals, dyes and pharmaceuticals and may be found in a variety of foods following formation during heating. The purpose of this study was to use two different in silico programs, CASE Ultra and Toxtree, to in...

journal_title：Toxicology mechanisms and methods

authors： Howard AS,Choksi N

更新日期：2020-05-01 00:00:00

abstract：:This study applied broccoli and cauliflower extracts (whole, floret, and stem) to zebrafish larvae in parallel to receive 100 mJ/cm(2) of UVB six times, and recorded their fin malformation phenotypes. Chemopreventive effects of each group, including UVB, whole-, floret-, and stem-extracts of broccoli and cauliflower o...

journal_title：Toxicology mechanisms and methods

authors： Chen YH,Wen CC,Lin CY,Chou CY,Yang ZS,Wang YH

更新日期：2011-01-01 00:00:00

abstract：:Toxicogenomics has evolved into a useful technique for providing greater mechanistic insights into adverse effects that will spur the development of novel approaches for identifying and understanding toxicity issues. The ability to capture a snapshot of the transcriptome at any given time during the development of an ...

journal_title：Toxicology mechanisms and methods

authors： Orr MS

更新日期：2006-01-01 00:00:00