Virtual population generator for human cardiomyocytes parameters: in silico drug cardiotoxicity assessment.

abstract：:The present study was designed for determining the exact mechanism of cytotoxic action of aluminum phosphide (AlP) in the presence of iron sucrose as the proposed antidote. Rats received AlP (12 mg/kg) and iron sucrose (5-30 mg/kg) in various sets and were connected to cardiovascular monitoring device. After identific...

journal_title：Toxicology mechanisms and methods

authors： Solgi R,Baghaei A,Golaghaei A,Hasani S,Baeeri M,Navaei M,Ostad SN,Hosseini R,Abdollahi M

更新日期：2015-01-01 00:00:00

abstract：:The CD1-haired mouse and the SKH-hairless mouse are two animal models that have been used to evaluate sulfur mustard (HD) exposure and protection in our laboratory. In a recent study we observed that a substance P inhibitor protected the haired mouse ear against an HD solution, but the same drug was not successful in ...

journal_title：Toxicology mechanisms and methods

authors： Logan TP,Shutz M,Schulz SM,Railer R,Ricketts KM,Casillas RP

更新日期：2002-01-01 00:00:00

abstract：UNLABELLED:Cisplatin (CP) is an antineoplastic agent that induces nephrotoxicity and oxidative stress. It is unknown whether renal tight junction (TJ) proteins expression and localization are modified in CP-induced nephrotoxicity. OBJECTIVE:To study if the expression of the TJ proteins occludin, claudin-2, claudin-5 a...

journal_title：Toxicology mechanisms and methods

authors： Trujillo J,Molina-Jijón E,Medina-Campos ON,Rodríguez-Muñoz R,Reyes JL,Loredo ML,Tapia E,Sánchez-Lozada LG,Barrera-Oviedo D,Pedraza-Chaverri J

更新日期：2014-10-01 00:00:00

abstract：:The aim of this work was to characterize inner mitochondrial membrane channels permeable to calcium cations (Ca(++)). Mitochondrial membranes isolated from rat heart were incorporated into the bilayer lipid membrane, and single Ca(++) channel currents were measured. The observed channels were selective for Ca(++) and ...

journal_title：Toxicology mechanisms and methods

authors： Komínková V,Novotová M,Ondrias K,Ravingerová T,Szewczyk A

更新日期：2004-01-01 00:00:00

abstract：:ABSTRACT The ideal toxicity biomarker is composed of the properties of prediction (is detected prior to traditional pathological signs of injury), accuracy (high sensitivity and specificity), and mechanistic relationships to the endpoint measured (biological relevance). Gene expression-based toxicity biomarkers ("sign...

journal_title：Toxicology mechanisms and methods

authors： Shi W,Bugrim A,Nikolsky Y,Nikolskya T,Brennan RJ

更新日期：2008-01-01 00:00:00

abstract：:Renal disease is a common complication of diabetes mellitus. The pathogenesis of diabetic nephropathy is not well understood, but hyperglycemia seems to be a crucial factor. Recent evidence indicates that the overproduction of reactive oxygen species, observed in both clinical and experimental diabetes, and mitochondr...

journal_title：Toxicology mechanisms and methods

authors： Seiça R,Santos DL,Palmeira CM,Moreno AJ,Sena C,Cunha MF,Santos MS

更新日期：2005-01-01 00:00:00

abstract：:We investigated the prooxidant effects of bisphenol A (BPA) phenoxyl radicals in comparison with the phenoxyl radicals of 3-tert-butyl-4-hydroxyanisole (BHA), 2,6-di-tert-butyl-methylphenol (BHT) and 4-tert-butylphenol (TBP). The phenoxyl radicals, generated in situ by 1-electron oxidation of the corresponding phenol,...

journal_title：Toxicology mechanisms and methods

authors： Babu S,Uppu S,Claville MO,Uppu RM

更新日期：2013-05-01 00:00:00

abstract：:Up to now, the ability of target cells to activate protein kinase C (PKC) and protein kinase D (PKD) (which is often a downstream target of PKC) has not been examined in natural killer (NK) lymphocytes. Here we examined whether exposure of human NK cells to lysis sensitive tumor cells activated PKC and PKD. The result...

journal_title：Toxicology mechanisms and methods

authors： Rana K,Whalen M

更新日期：2015-01-01 00:00:00

abstract：:Abstract The effects of 4-hydroxytamoxifen (OHTAM) on the mitochondrial permeability transition (MPT) induced by Ca(2+) plus peroxynitrite (ONOO(-)) or phenylarsine oxide (PhAsO) were studied to clarify its mechanisms of MPT inhibition. Ca(2+) plus ONOO(-) induced mitochondrial swelling, membrane potential (Delta Psi)...

journal_title：Toxicology mechanisms and methods

authors： Cardoso CM,Almeida LM,Custódio JB

更新日期：2005-01-01 00:00:00

abstract：:In cosmetics and food products, parabens are widely used as antimicrobial agents. Reports have suggested that parabens may be linked to infertility, owing to their effects on basal steroidogenesis properties or their capacity to inflict mitochondrial damage. Despite growing concerns about parabens as endocrine disrupt...

journal_title：Toxicology mechanisms and methods

authors： Herrera-Cogco E,López-Bayghen B,Hernández-Melchor D,López-Luna A,Palafox-Gómez C,Ramírez-Martínez L,López-Bello E,Albores A,López-Bayghen E

更新日期：2020-06-01 00:00:00

abstract：:In pregnancy, opioids may be used medically and also misused. We hypothesized that the umbilical cord (UC) could be a good screening tool for determining opioid exposure and improving medical care. One hundred and one UC, each with 50 associated ICD9/ICD10 codes were used. Using predictive pharmacokinetic analysis we ...

journal_title：Toxicology mechanisms and methods

authors： Knight SJ,Smith AD,Wright TE,Collier AC

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS:In this study, different concentrations of arsenic w...

journal_title：Toxicology mechanisms and methods

authors： Phan NN,Li KL,Lin YC

更新日期：2018-07-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of different doses of an adenosine A(1) selective agonist, phenylisopropyl adenosine (PIA), on metamidophos-induced cholinergic symptoms, mortality, diaphragm muscle necrosis, and brain oxidative stress. A LD(50) dose of metamidophos (20 mg/kg body weight, p.o.) was fo...

journal_title：Toxicology mechanisms and methods

authors： Kalkan S,Ozdemir D,Ergur BU,Hazardin NU,Akgun A,Topcu A,Kaplan YC,Hocaoglu N,Oransay K,Tuncok Y

更新日期：2009-02-01 00:00:00

abstract：:Prochloraz is a broad-spectrum contact imidazol fungicide used against several diseases in wheat, barley and oleaginous plants but also for treatment of flower production. Although prochloraz has endocrine disrupting and hepatocarcinogenic effects, there is lack of data on toxic effects of prochloraz. Therefore, we ai...

journal_title：Toxicology mechanisms and methods

authors： Alpertunga B,Kara M,Abudayyak M,Oztas E,Ozden S,Ozhan G

更新日期：2014-05-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNTs) have industrial applications in the nanotechnology field. The physico-chemical properties of MWCNTs vary greatly depending on MWCNT manufacture and application. It has been pointed out that their needle shape and high durability are important factors that determine the biopersist...

journal_title：Toxicology mechanisms and methods

authors： Fujita K,Obara S,Maru J,Endoh S

更新日期：2020-09-01 00:00:00

abstract：:Crotonaldehyde is a ubiquitous hazardous pollutant, present in cigarette smoke and automobile exhaust and is endogenously generated by lipid peroxidation. Most of the current studies focus on its lung toxicity. However, there have been few investigations on the cardiac and renal toxicity caused by crotonaldehyde expos...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Li S,Men J,Peng C,Shao H,Zhang Z

更新日期：2019-05-01 00:00:00

abstract：:The brain is a well-organized, yet highly complex, organ in the mammalian system. Most investigators use the whole brain, instead of a selected brain region(s), for biochemical analytes as toxicological endpoints. As a result, the obtained data is often of limited value, since their significance is compromised due to ...

journal_title：Toxicology mechanisms and methods

authors： Gupta RC

更新日期：2004-01-01 00:00:00

abstract：:For good performance in clinical and forensic toxicology, it is important to be aware of the signs and symptoms related to xenobiotic exposure since they will assist clinicians to reach a useful and rapid diagnosis. This manuscript highlights and critically analyses clinical and forensic imaging related to ethanol abu...

journal_title：Toxicology mechanisms and methods

authors： Dinis-Oliveira RJ,Magalhães T,Moreira R,Proença JB,Pontes H,Santos A,Duarte JA,Carvalho F

更新日期：2014-02-01 00:00:00

abstract：:The β-glucans (β-G) are polysaccharides produced by various organisms, and sulfation of β-G renders them more soluble. With the objective to assess the effects of sulfated and non-sulfated β-G extracted from Agaricus brasiliensis in MCF-7 cells, assays were used to evaluate cytotoxicity, genotoxicity, cell proliferati...

journal_title：Toxicology mechanisms and methods

authors： Baranoski A,Tempesta Oliveira M,Semprebon SC,Niwa AM,Ribeiro LR,Mantovani MS

更新日期：2015-01-01 00:00:00

abstract：:We investigated the effect of two extracts from Peruvian plants given alone or in a mixture on sperm count and glycemia in streptozotocin-diabetic mice. Normal or diabetic mice were divided in groups receiving vehicle, black maca (Lepidium meyenii), yacon (Smallanthus sonchifolius) or three mixtures of extracts black ...

journal_title：Toxicology mechanisms and methods

authors： Gonzales GF,Gonzales-Castañeda C,Gasco M

更新日期：2013-09-01 00:00:00

abstract：:The present study was designed to determine whether the treatment with an ethanolic extract of pomegranate (EEP) (Punica granatum) can be useful for the treatment of the deleterious effect of lead acetate (LA) administration on sperm production in rats. The effects of EEP were compared with those of ascorbic acid (AA)...

journal_title：Toxicology mechanisms and methods

authors： Leiva KP,Rubio J,Peralta F,Gonzales GF

更新日期：2011-07-01 00:00:00

abstract：:Clinical use of doxorubicin continues to be challenged by its undesirable systematic toxicity, caused mainly by oxidative stress. The aim of this study was to investigate the effectiveness of fullerenol C(60)(OH)(24) polyanion nanoparticles, an antioxidant agent, against doxorubicin-induced nephro-, testicular, and pu...

journal_title：Toxicology mechanisms and methods

authors： Srdjenovic B,Milic-Torres V,Grujic N,Stankov K,Djordjevic A,Vasovic V

更新日期：2010-07-01 00:00:00

abstract：:Some environmental pollutants derived from industrial processes have been suggested to be responsible for neurological impairment in children, especially in heavily polluted areas. Since these compounds are usually activators of aryl hydrocarbon receptor (AhR), it would be important to better understand the molecular ...

journal_title：Toxicology mechanisms and methods

authors： Imran S,Ferretti P,Vrzal R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Oxytocin (OT) injections have been indiscriminately used to milk cattle in dairy industries. There is no study available regarding surveillance of OT in market milk samples. MATERIAL AND METHODS:OT from milk samples was extracted by precipitation with trichloroacetic acid and passed through the solid phase ...

journal_title：Toxicology mechanisms and methods

authors： Mishra M,Ali S,Das M

更新日期：2014-06-01 00:00:00

abstract：:ABSTRACT The effect of sodium selenite, alpha-tocopherol, and their combination was studied in the hemic system of goat. Incubation of goat blood with selenium and vitamin E for 24 h resulted in a decrease in hemoglobin concentrations in Se-and vitamin E-treated groups, whereas no change in the osmotic fragility was o...

journal_title：Toxicology mechanisms and methods

authors： Saini RK,Saini N,Kataria M,Babu S

更新日期：2007-01-01 00:00:00

abstract：:The authors have previously shown that high alcohol preference rats (HAP) have a significantly higher sensitivity than low alcohol preference rats (LAP) for methamphetamine (MAP). In this study, changes in dopamine and serotonin release induced by MAP (1 mg/kg, intraperitoneally) after pre-treatment with D1 and D2 rec...

journal_title：Toxicology mechanisms and methods

authors： Nishiguchi M,Kinoshita H,Kasuda S,Takahashi M,Yamamura T,Matsui K,Ouchi H,Minami T,Hishida S,Nishio H

更新日期：2010-03-01 00:00:00

abstract：CONTEXT:Although the liver is the primary target organ in acetaminophen (APAP) toxicity, other organs are affected. Previous data suggested that chronic APAP abuse can be ototoxic and the mechanism involves APAP-induced oxidative stress and reactive metabolite (N-acetyl-p-benzoquinone imine, NAPQI)-induced endoplasmic ...

journal_title：Toxicology mechanisms and methods

authors： McGill MR,Kennon-McGill S,Durham D,Jaeschke H

更新日期：2016-02-01 00:00:00

abstract：:Due to their exceptional properties, gold nanoparticles (AuNPs) have shown promising medical and technological applications in the treatment of cancer and the development of antimicrobial packaging and time-temperature indicators in the food sector. However, little is known about their cytotoxicity when they come into...

journal_title：Toxicology mechanisms and methods

authors： Mateo D,Morales P,Ávalos A,Haza AI

更新日期：2014-03-01 00:00:00

abstract：:The study aims at evaluating the combination of the quinocetone and the ML-7 in preclinical hepatocellular carcinoma models. To this end, the effect of quinocetone and ML-7 on apoptosis induction and signaling pathways was analyzed on HepG2 cell lines. Here, we report that ML-7, in a nontoxic concentration, sensitized...

journal_title：Toxicology mechanisms and methods

authors： Zhou Y,Zhang S,Deng S,Dai C,Tang S,Yang X,Li D,Zhao K,Xiao X

更新日期：2016-01-01 00:00:00

abstract：:In the present investigation acetylcholinesterase (AChE) was estimated in erythrocytes from blood samples exposed to four commonly used organophosphorus pesticides in vitro. The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitor...

journal_title：Toxicology mechanisms and methods

authors： Das GP,Jamil K,Rahman MF

更新日期：2006-01-01 00:00:00