Effects of prochloraz on DNA damage, lipid peroxidation and antioxidant system in vitro.

abstract：:Oxidative stress in biological systems can result in radical-induced lipid peroxidation (LPO), which can lead to the production of secondary reactive by-products such as 4-hydroxy-2-nonenal (HNE), malondialdehyde (MDA), acrolein, and acetaldehyde. These deleterious compounds are known to react with and concomitantly m...

journal_title：Toxicology mechanisms and methods

authors： Rainey RP,Gillman IG,Shi X,Cheng T,Stinson A,Gietl D,Albino AP

更新日期：2009-09-01 00:00:00

abstract：:A potency of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) to reactivate cyclosarin-inhibited acetylcholinesterase and to reduce cyclosarin-induced acute toxic effects was evaluated in this study. In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue ac...

journal_title：Toxicology mechanisms and methods

authors： Kassa J,Karasova JZ,Musilek K,Kuca K

更新日期：2009-06-01 00:00:00

abstract：:Limited information is available regarding systemic changes in mammals associated with exposures to petroleum/hydrocarbon fuels. In this study, systemic toxicity of JP-8 jet fuel was observed in a rat inhalation model at different JP-8 fuel vapor concentrations (250, 500, or 1000 mg/m(3), for 91 days). Gel electrophor...

journal_title：Toxicology mechanisms and methods

authors： Hanas JS,Bruce Briggs G,Lerner MR,Lightfoot SA,Larabee JL,Karsies TJ,Epstein RB,Hanas RJ,Brackett DJ,Hocker JR

更新日期：2010-05-01 00:00:00

abstract：:Cadmium is one of the most toxic elements to which man can be exposed at work or in the environment. By far, the most salient toxicological property of Cd is its exceptionally long half-life in the human body. Once absorbed, Cd accumulates in the human body, particularly in the liver and other vital organs. The cellul...

journal_title：Toxicology mechanisms and methods

authors： Escobar Mdel C,Souza V,Bucio L,Hernández E,Gómez-Quiroz LE,Gutiérrez Ruiz MC

更新日期：2009-10-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNTs) have industrial applications in the nanotechnology field. The physico-chemical properties of MWCNTs vary greatly depending on MWCNT manufacture and application. It has been pointed out that their needle shape and high durability are important factors that determine the biopersist...

journal_title：Toxicology mechanisms and methods

authors： Fujita K,Obara S,Maru J,Endoh S

更新日期：2020-09-01 00:00:00

abstract：:The current study evaluated in vitro and in vivo toxicity of carboxyl or amine polyethylene glycol (PEG) surface functionalization of single-walled carbon nanotubes (SWCNTs). Assessments of cytotoxicity, genotoxicity, immunotoxicity, and oxidative stress were performed in vitro and in vivo (in a 1-month follow-up stud...

journal_title：Toxicology mechanisms and methods

authors： Shaik AS,Shaik AP,Bammidi VK,Al Faraj A

更新日期：2019-05-01 00:00:00

abstract：:The present study was designed to investigate the effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats. Sprague-Dawley rats were subcutaneously injected with isoproterenol (20 mg/kg). Cardiac marker enzymes in serum, antioxidative parameters and inflammatory...

journal_title：Toxicology mechanisms and methods

authors： Gai Y,Ma Z,Yu X,Qu S,Sui D

更新日期：2012-10-01 00:00:00

abstract：:The present study was designed to determine whether the treatment with an ethanolic extract of pomegranate (EEP) (Punica granatum) can be useful for the treatment of the deleterious effect of lead acetate (LA) administration on sperm production in rats. The effects of EEP were compared with those of ascorbic acid (AA)...

journal_title：Toxicology mechanisms and methods

authors： Leiva KP,Rubio J,Peralta F,Gonzales GF

更新日期：2011-07-01 00:00:00

abstract：:A suboptimal in utero environment can have detrimental effects on the pregnancy and long-term adverse "programing" effects on the offspring. Aflatoxin B1 is one of the potent reproductive toxicants and currently detected in both milk and tissues. This article focuses on the effects of prenatal exposure to graded doses...

journal_title：Toxicology mechanisms and methods

authors： Supriya Ch,Akhila B,Pratap Reddy K,Girish BP,Sreenivasula Reddy P

更新日期：2016-01-01 00:00:00

abstract：:The implications of delta-aminolevulinic acid dehydratase (ALAD) polymorphism for lead kinetics and toxicity have been mainly studied in occupationally exposed adults. Therefore, our purpose was to evaluate the distribution of ALAD genotype and its association with biomarkers of exposure (PbB levels) and effect (Blood...

journal_title：Toxicology mechanisms and methods

authors： Mijares IA,López P,Rosado JL,Cebrián A,Vera-Aguilar E,Alatorre J,Quintanilla-Vega MB,García AE,Stoltzfus RJ,Cebrián ME,García-Vargas GG

更新日期：2006-01-01 00:00:00

abstract：:Crotonaldehyde is a hazardous pollutant present in cigarette smoke and automobile exhausts that is generated by lipid peroxidation, and harmful to reproductive organs. Although we are often exposed to low doses of crotonaldehyde daily, its adverse effects on the reproductive organs have not been fully elucidated. To e...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Wei P,Men J,Zhang S,Shao H,Zhang Z

更新日期：2020-01-01 00:00:00

abstract：:During an avian mass mortality event investigation at the National Fish and Wildlife Forensic Laboratory in Ashland, OR, imidacloprid became an insecticide of concern. A qualitative analytical toxicology screen of seeds, plucks (tongue, esophagus, and trachea), and ventricular contents was requested. A method for the ...

journal_title：Toxicology mechanisms and methods

authors： Buchweitz JP,Viner TC,Lehner AF

更新日期：2019-09-01 00:00:00

abstract：:Angiogenesis, disturbance in redox homeostasis, and deregulated redox signaling are considered as common hallmarks of cancer progression and chemo resistance. In this context, PERK (protein kinase PKR-like ER kinase) branch of the unfolded protein response (UPR), an adaptive mechanism triggered by endoplasmic reticulu...

journal_title：Toxicology mechanisms and methods

authors： Sharma SH,Suresh Kumar J,Madhavan S,Nagarajan S

更新日期：2020-05-01 00:00:00

abstract：:Misuse of various chemicals, such as chemical warfare agents, industrial chemicals or pesticides during warfare or terrorists attacks requires adequate protection. Thus, development and evaluation of novel decontamination dispositives and techniques are needed. In this study, in vitro permeation and decontamination of...

journal_title：Toxicology mechanisms and methods

authors： Misik J,Pavlikova R,Josse D,Cabal J,Kuca K

更新日期：2012-09-01 00:00:00

abstract：:ABSTRACT Male Wistar rats with streptozotocin-induced diabetes received a control diet and a pyridoxine-deficient diet. The animals were divided at random into four groups: control rats (CR), control diabetic rats (CDR), diabetic rats receiving a pyridoxine-free diet (DRB6), and diabetic rats receiving saline solution...

journal_title：Toxicology mechanisms and methods

authors： Jordao AA,Dos Santos FL,Marchini JS,Vannucchi H

更新日期：2007-01-01 00:00:00

abstract：:The epidemiological association between black cherry trees and mare reproductive loss syndrome has focused attention on cyanide and environmental cyanogens. This article describes the toxicokinetics of cyanide in horses and the relationships between blood cyanide concentrations and potentially adverse responses to cya...

journal_title：Toxicology mechanisms and methods

authors： Dirikolu L,Hughes C,Harkins D,Boyles J,Bosken J,Lehner F,Troppmann A,McDowell K,Tobin T,Sebastian MM,Harrison L,Crutchfield J,Baskin SI,Fitzgerald TD

更新日期：2003-01-01 00:00:00

abstract：:Up to now, the ability of target cells to activate protein kinase C (PKC) and protein kinase D (PKD) (which is often a downstream target of PKC) has not been examined in natural killer (NK) lymphocytes. Here we examined whether exposure of human NK cells to lysis sensitive tumor cells activated PKC and PKD. The result...

journal_title：Toxicology mechanisms and methods

authors： Rana K,Whalen M

更新日期：2015-01-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) is a highly toxic industrial solvent with pronounced systemic toxicity including brain. Neurotoxicity may be a direct result of hepatic dysfunction from CCl4 intoxication. Over the years CCl4 has been used as an excellent model for studying experimentally induced neurotoxicity in murine mod...

journal_title：Toxicology mechanisms and methods

authors： Naseem M,Parvez S

更新日期：2014-10-01 00:00:00

abstract：:In pregnancy, opioids may be used medically and also misused. We hypothesized that the umbilical cord (UC) could be a good screening tool for determining opioid exposure and improving medical care. One hundred and one UC, each with 50 associated ICD9/ICD10 codes were used. Using predictive pharmacokinetic analysis we ...

journal_title：Toxicology mechanisms and methods

authors： Knight SJ,Smith AD,Wright TE,Collier AC

更新日期：2019-01-01 00:00:00

abstract：:The present study was designed to investigate the effects of aqueous Azadirchta Indica leaf extract (AAILE) on serum glycoprotein contents and tumor incidence rate in colon of rats subjected to Dimethylhydrazine (DMH) treatment. Forty rats were divided equally and randomly into four groups viz., Group I (normal contro...

journal_title：Toxicology mechanisms and methods

authors： Ramzanighara A,Ezzatighadi F,Rai DV,Dhawan DK

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Oxytocin (OT) injections have been indiscriminately used to milk cattle in dairy industries. There is no study available regarding surveillance of OT in market milk samples. MATERIAL AND METHODS:OT from milk samples was extracted by precipitation with trichloroacetic acid and passed through the solid phase ...

journal_title：Toxicology mechanisms and methods

authors： Mishra M,Ali S,Das M

更新日期：2014-06-01 00:00:00

abstract：:Chlorine gas is one of the highly produced chemicals in the USA and around the world. Chlorine gas has several uses in water purification, sanitation, and industrial applications; however, it is a toxic inhalation hazard agent. Inhalation of chlorine gas, based on the concentration and duration of the exposure, causes...

journal_title：Toxicology mechanisms and methods

authors： Achanta S,Jordt SE

更新日期：2019-10-01 00:00:00

abstract：:The CD1-haired mouse and the SKH-hairless mouse are two animal models that have been used to evaluate sulfur mustard (HD) exposure and protection in our laboratory. In a recent study we observed that a substance P inhibitor protected the haired mouse ear against an HD solution, but the same drug was not successful in ...

journal_title：Toxicology mechanisms and methods

authors： Logan TP,Shutz M,Schulz SM,Railer R,Ricketts KM,Casillas RP

更新日期：2002-01-01 00:00:00

abstract：:Tumor progression is the continual selection of variant subpopulations of malignant cells that have acquired increasing levels of genetic instability (Nowell Science 1976, 194, 23-28). This instability is manifested as chromosomal aneuploidy or translocations, viral integration or somatic mutations that typically affe...

journal_title：Toxicology mechanisms and methods

authors： Huppi K,Pitt J,Wahlberg B,Caplen NJ

更新日期：2011-05-01 00:00:00

abstract：:Ethanol metabolism induces generation of excessive amount of reactive oxygen species (ROS) which results in immune dysfunction. We examined the efficacy of silymarin on ethanol-induced oxidative stress, immunomodulatory activity, and vascular function in mice blood. Effectiveness of silymarin was compared with potent ...

journal_title：Toxicology mechanisms and methods

authors： Das SK,Mukherjee S

更新日期：2012-06-01 00:00:00

abstract：:Silver and gold nanoparticles (Ag-AuNPs) are currently some of the most manufactured nanomaterials. Accordingly, the hazards associated with human exposure to Ag-AuNPs should be investigated to facilitate the risk assessment process. In particular, because pulmonary exposure to Ag-AuNPs occurs during handling of these...

journal_title：Toxicology mechanisms and methods

authors： Ávalos A,Haza AI,Mateo D,Morales P

更新日期：2015-01-01 00:00:00

abstract：AIM:Nicotine exerts a number of physiological effects. The purpose of this study was to determine the effects of nicotine on thioacetamide (TAA)-induced liver fibrosis in mice. MATERIALS AND METHODS:For in vivo experiments, hepatic fibrosis was induced by TAA (0.25 g/kg, i.p.) three times a week for 6 weeks. Mice of T...

journal_title：Toxicology mechanisms and methods

authors： Zhou Z,Park S,Kim JW,Zhao J,Lee MY,Choi KC,Lim CW,Kim B

更新日期：2017-09-01 00:00:00

abstract：:Preeclampsia is a multisystem disorder with profound implications on both mother and fetus. Analysis of umbilical cord blood red blood cell (RBC) changes shall depict the fetal response to pregnancy-specific complications like preeclampsia. This study aims to analyze the regulation relationship between HSP90α and heme...

journal_title：Toxicology mechanisms and methods

authors： Ekambaram P,Jayachandran T,Dhakshinamoorthy L

更新日期：2013-02-01 00:00:00

abstract：:Chronic hyperglycemia leads to the development of microvascular complications like diabetic nephropathy. The present study investigated the potential effects of the hydroalcoholic extract of Tribulus terrestris, a plant of Zygophyllaceae family, on the renal complications in streptozotocin (STZ)-induced diabetic rats....

journal_title：Toxicology mechanisms and methods

authors： Gandhi S,Srinivasan BP,Akarte AS

更新日期：2013-09-01 00:00:00

abstract：:The need for reliable results in Toxicological Analysis is recognized and required worldwide. The analytical validation ensures that a method will provide trustworthy information about a particular sample when applied in accordance with a predefined protocol, being able to determine a specific analyte at a distinct co...

journal_title：Toxicology mechanisms and methods

authors： Abrão LCC,Silveira AT,de Faria HD,Machado SC,Mendes TV,Plácido RV,Marciano LPA,Martins I

更新日期：2021-01-01 00:00:00