Potential nephrotoxic effects produced by steroidal saponins from hydro alcoholic extract of Tribulus terrestris in STZ-induced diabetic rats.

abstract：BACKGROUND:Oxytocin (OT) injections have been indiscriminately used to milk cattle in dairy industries. There is no study available regarding surveillance of OT in market milk samples. MATERIAL AND METHODS:OT from milk samples was extracted by precipitation with trichloroacetic acid and passed through the solid phase ...

journal_title：Toxicology mechanisms and methods

authors： Mishra M,Ali S,Das M

更新日期：2014-06-01 00:00:00

abstract：:Angiogenesis, disturbance in redox homeostasis, and deregulated redox signaling are considered as common hallmarks of cancer progression and chemo resistance. In this context, PERK (protein kinase PKR-like ER kinase) branch of the unfolded protein response (UPR), an adaptive mechanism triggered by endoplasmic reticulu...

journal_title：Toxicology mechanisms and methods

authors： Sharma SH,Suresh Kumar J,Madhavan S,Nagarajan S

更新日期：2020-05-01 00:00:00

abstract：AIM:Nicotine exerts a number of physiological effects. The purpose of this study was to determine the effects of nicotine on thioacetamide (TAA)-induced liver fibrosis in mice. MATERIALS AND METHODS:For in vivo experiments, hepatic fibrosis was induced by TAA (0.25 g/kg, i.p.) three times a week for 6 weeks. Mice of T...

journal_title：Toxicology mechanisms and methods

authors： Zhou Z,Park S,Kim JW,Zhao J,Lee MY,Choi KC,Lim CW,Kim B

更新日期：2017-09-01 00:00:00

abstract：:How triptolide is associated with mitochondrial dysfunction and apoptosis in connection with its hepatotoxicity remains unclear. The objective of our study was to find out the link between mitochondrial dynamics and cell death in triptolide induced hepatotoxicity. We treated L02 cells with 25 nM concentration of tript...

journal_title：Toxicology mechanisms and methods

authors： Hasnat M,Yuan Z,Ullah A,Naveed M,Raza F,Baig MMFA,Khan A,Xu D,Su Y,Sun L,Zhang L,Jiang Z

更新日期：2020-02-01 00:00:00

abstract：:Owing to their structure and function, low-density lipoproteins (LDLs) are particularly susceptible to the oxidative modifications. To prevent against oxidative modification of LDL, L-carnitine, with endogenous small water-soluble quaternary amine possessing antioxidative properties, was used. The aim of this paper wa...

journal_title：Toxicology mechanisms and methods

authors： Augustyniak A,Stankiewicz A,Skrzydlewska E

更新日期：2008-07-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) activity is used widely as a biomarker for tumor promotion in animal model systems. Several previous studies have reported increases in ODC activity in tissues of rats exposed to 60 Hz magnetic fields. The goals of this study were to confirm these findings and to determine whether ODC act...

journal_title：Toxicology mechanisms and methods

authors： McDonald LJ,Loberg LI,McCormick DL,Gauger JR,Savage RE Jr,Zhu H,Lotz WG,Mandeville R,Owen RD,Cress LW,Desta AB

更新日期：2003-01-01 00:00:00

abstract：:ABSTRACT The present investigation was undertaken to examine the effects of chlorpyrifos (CP, an organophosphate) and deltamethrin (DM, a pyrethroid pesticide) treatments at low and high doses and their combination on lipid peroxidation and antioxidant enzyme activities such as SOD, GSH-Px, and CAT and also AChE activ...

journal_title：Toxicology mechanisms and methods

authors： Tüzmen MN,Candan N,Kaya E

更新日期：2007-01-01 00:00:00

abstract：:Oral cocaine administration results in hepatic necrosis, increased plasma transaminase concentration, and decreased antioxidative capability, which is potentiated by lipopolysaccharide (LPS) in male CF-1 mice. Females administered the same treatment regimen display none of the hepatotoxic effects seen in their male co...

journal_title：Toxicology mechanisms and methods

authors： Visalli T,Turkall R,Abdel-Rahman MS

更新日期：2005-01-01 00:00:00

abstract：:Crotonaldehyde is a ubiquitous hazardous pollutant, present in cigarette smoke and automobile exhaust and is endogenously generated by lipid peroxidation. Most of the current studies focus on its lung toxicity. However, there have been few investigations on the cardiac and renal toxicity caused by crotonaldehyde expos...

journal_title：Toxicology mechanisms and methods

authors： Zhang B,Li S,Men J,Peng C,Shao H,Zhang Z

更新日期：2019-05-01 00:00:00

abstract：:Ethanol metabolism is accompanied by generation of free radicals that damage cell components, especially lipids. The present study was designed to investigate the efficacy of the preventive effect of black tea on the lipid oxidative modifications in different tissues (plasma, liver, brain, kidney, stomach, lung, intes...

journal_title：Toxicology mechanisms and methods

authors： Luczaj W,Welerowicz T,Skrzydlewska E,Buszewski B

更新日期：2008-07-01 00:00:00

abstract：:The influence of experimental conditions on gradient high-performance liquid chromatography/diode array detector separation and identification of 13 psychotropic drugs belonging to two groups--phenothiazines and tricyclic antidepressants--was examined. The main interaction effects of three experimental factors were de...

journal_title：Toxicology mechanisms and methods

authors： Madej K,Parczewski A,Kała M

更新日期：2003-01-01 00:00:00

abstract：:Dioxins and dioxin-like compounds (DLCs) are the ones with poor water solubility and low volatility, resistant to physical, chemical and biological processes, persistent in the environment even under extreme conditions. Due to lipophilic nature, they get adhered to the fatty material and concentrate through biomagnifi...

journal_title：Toxicology mechanisms and methods

authors： Khan MF,Alam MM,Verma G,Akhtar W,Rizvi MA,Ali A,Akhter M,Shaquiquzzaman M

更新日期：2017-02-01 00:00:00

abstract：:In pregnancy, opioids may be used medically and also misused. We hypothesized that the umbilical cord (UC) could be a good screening tool for determining opioid exposure and improving medical care. One hundred and one UC, each with 50 associated ICD9/ICD10 codes were used. Using predictive pharmacokinetic analysis we ...

journal_title：Toxicology mechanisms and methods

authors： Knight SJ,Smith AD,Wright TE,Collier AC

更新日期：2019-01-01 00:00:00

abstract：:This study was to evaluate the protective effects of Danshensu on liver injury induced by omethoate in Sprague Dawley rats. The acute omethoate poisoning model was established by administrating subcutaneously with omethoate at a single dose of 60 mg/kg. Danshensu treatment markedly inhibited the increases of aspartate...

journal_title：Toxicology mechanisms and methods

authors： Ren R,Wang T,Jiang N,Liu T,Du Y,Li C,Zhang L,Fu F

更新日期：2010-10-01 00:00:00

abstract：:Concern over the influence of carbon nanotubes (CNTs) on human health has arisen due to advances; however, little is known about the potential toxicity of CNTs. In this study, impurity-free single-wall carbon nanotubes (SWCNTs), with different physical properties in cell culture medium, were prepared by a novel disper...

journal_title：Toxicology mechanisms and methods

authors： Fujita K,Fukuda M,Endoh S,Kato H,Maru J,Nakamura A,Uchino K,Shinohara N,Obara S,Nagano R,Horie M,Kinugasa S,Hashimoto H,Kishimoto A

更新日期：2013-10-01 00:00:00

abstract：:Abstract The effects of 4-hydroxytamoxifen (OHTAM) on the mitochondrial permeability transition (MPT) induced by Ca(2+) plus peroxynitrite (ONOO(-)) or phenylarsine oxide (PhAsO) were studied to clarify its mechanisms of MPT inhibition. Ca(2+) plus ONOO(-) induced mitochondrial swelling, membrane potential (Delta Psi)...

journal_title：Toxicology mechanisms and methods

authors： Cardoso CM,Almeida LM,Custódio JB

更新日期：2005-01-01 00:00:00

abstract：:Due to their exceptional properties, gold nanoparticles (AuNPs) have shown promising medical and technological applications in the treatment of cancer and the development of antimicrobial packaging and time-temperature indicators in the food sector. However, little is known about their cytotoxicity when they come into...

journal_title：Toxicology mechanisms and methods

authors： Mateo D,Morales P,Ávalos A,Haza AI

更新日期：2014-03-01 00:00:00

abstract：:In cosmetics and food products, parabens are widely used as antimicrobial agents. Reports have suggested that parabens may be linked to infertility, owing to their effects on basal steroidogenesis properties or their capacity to inflict mitochondrial damage. Despite growing concerns about parabens as endocrine disrupt...

journal_title：Toxicology mechanisms and methods

authors： Herrera-Cogco E,López-Bayghen B,Hernández-Melchor D,López-Luna A,Palafox-Gómez C,Ramírez-Martínez L,López-Bello E,Albores A,López-Bayghen E

更新日期：2020-06-01 00:00:00

abstract：:The present study was designed to determine whether the treatment with an ethanolic extract of pomegranate (EEP) (Punica granatum) can be useful for the treatment of the deleterious effect of lead acetate (LA) administration on sperm production in rats. The effects of EEP were compared with those of ascorbic acid (AA)...

journal_title：Toxicology mechanisms and methods

authors： Leiva KP,Rubio J,Peralta F,Gonzales GF

更新日期：2011-07-01 00:00:00

abstract：:Miniscrew implants are widely used nowadays in orthodontic treatments due to their good results in clinical practice. However, data regarding the biocompatibility of commercially available orthodontic miniscrews and temporary devices are very scarce, and their role as genotoxicity inducers has been not previously eval...

journal_title：Toxicology mechanisms and methods

authors： Martín-Cameán A,Puerto M,Jos Á,Azqueta A,Iglesias-Linares A,Solano E,Cameán AM

更新日期：2015-01-01 00:00:00

abstract：:The aim of this work was to characterize inner mitochondrial membrane channels permeable to calcium cations (Ca(++)). Mitochondrial membranes isolated from rat heart were incorporated into the bilayer lipid membrane, and single Ca(++) channel currents were measured. The observed channels were selective for Ca(++) and ...

journal_title：Toxicology mechanisms and methods

authors： Komínková V,Novotová M,Ondrias K,Ravingerová T,Szewczyk A

更新日期：2004-01-01 00:00:00

abstract：:Up to now, the ability of target cells to activate protein kinase C (PKC) and protein kinase D (PKD) (which is often a downstream target of PKC) has not been examined in natural killer (NK) lymphocytes. Here we examined whether exposure of human NK cells to lysis sensitive tumor cells activated PKC and PKD. The result...

journal_title：Toxicology mechanisms and methods

authors： Rana K,Whalen M

更新日期：2015-01-01 00:00:00

abstract：:Allergic rhinitis (also known as hay fever) is the most commonly occurring immunological disorder, and it affects 40 million men, women, and children in the United States. Symptomatically, it is an inflammation and irritation of the mucous membranes that line the nose. Allergy is defined as a state of hypersensitivity...

journal_title：Toxicology mechanisms and methods

authors： Amit A,Saxena VS,Pratibha N,Bagchi M,Bagchi D,Stohs SJ

更新日期：2003-01-01 00:00:00

abstract：:In recent years, diabetes and its associated complications have come to represent a major public health concern. It is a complex disease characterized by multiple metabolic derangements and is known to impair cardiac function by disrupting the balance between pro-oxidants and antioxidants at the cellular level. The su...

journal_title：Toxicology mechanisms and methods

authors： Selvaraju V,Joshi M,Suresh S,Sanchez JA,Maulik N,Maulik G

更新日期：2012-06-01 00:00:00

abstract：:Oxidative stress in biological systems can result in radical-induced lipid peroxidation (LPO), which can lead to the production of secondary reactive by-products such as 4-hydroxy-2-nonenal (HNE), malondialdehyde (MDA), acrolein, and acetaldehyde. These deleterious compounds are known to react with and concomitantly m...

journal_title：Toxicology mechanisms and methods

authors： Rainey RP,Gillman IG,Shi X,Cheng T,Stinson A,Gietl D,Albino AP

更新日期：2009-09-01 00:00:00

abstract：:Hydroquinone (HQ), one of the most important metabolites derived from benzene, is known to be associated with acute myelogenous leukemia risk; however, its carcinogenic mechanism remains unclear. In a previous study, we found that low-level of benzene exposure down-regulated the expression of poly(ADP-ribose)polymeras...

journal_title：Toxicology mechanisms and methods

authors： Sha Y,Zhou W,Yang Z,Zhu X,Yang X,Li TD,Zhu D

更新日期：2015-01-01 00:00:00

abstract：:The specific properties of silver nanoparticles (AgNPs), such as antimicrobial activity and electrical conductivity, allow them to be used in many fields. However, their expanding application is also raising health, environmental and safety concerns. Previous in vivo AgNP toxicity studies have indicated a gender-diffe...

journal_title：Toxicology mechanisms and methods

authors： Dong MS,Choi JY,Sung JH,Kim JS,Song KS,Ryu HR,Lee JH,Bang IS,An K,Park HM,Song NW,Yu IJ

更新日期：2013-07-01 00:00:00

abstract：:ABSTRACT Dermal exposure to JP-8 petroleum jet fuel leads to toxicological responses in humans and rodents. Serum profiling is a molecular analysis of changes in the levels of serum proteins and other molecules in response to changes in physiology. This present study utilizes serum profiling approaches to examine biom...

journal_title：Toxicology mechanisms and methods

authors： Larabee JL,Hocker JR,Cheung JY,Gallucci RM,Hanas JS

更新日期：2008-01-01 00:00:00

abstract：CONTEXT:Although the liver is the primary target organ in acetaminophen (APAP) toxicity, other organs are affected. Previous data suggested that chronic APAP abuse can be ototoxic and the mechanism involves APAP-induced oxidative stress and reactive metabolite (N-acetyl-p-benzoquinone imine, NAPQI)-induced endoplasmic ...

journal_title：Toxicology mechanisms and methods

authors： McGill MR,Kennon-McGill S,Durham D,Jaeschke H

更新日期：2016-02-01 00:00:00

abstract：:ABSTRACT This paper presents the results from an evaluation of the noncommercial, (quantitative) structure-activity relationship ([Q]SAR) models for the prediction of mutagenicity and carcinogenicity, carried out in a collaboration between the European Chemicals Bureau Group on Computational Toxicology and the Italian...

journal_title：Toxicology mechanisms and methods

authors： Benigni R,Bossa C

更新日期：2008-01-01 00:00:00