Serum Profiling of Rat Dermal Exposure to JP-8 Fuel Reveals an Acute-Phase Response.

abstract：:Nicotine, an active substance present in tobacco has been identified as a major risk factor for lung related diseases. In the present study, we have evaluated the protective effect of curcumin on circulatory lipid peroxidation and antioxidants in nicotine administered Wistar rats. Lung toxicity was induced by subcutan...

journal_title：Toxicology mechanisms and methods

authors： Kalpana C,Menon VP

更新日期：2004-01-01 00:00:00

abstract：:ABSTRACT Male Wistar rats with streptozotocin-induced diabetes received a control diet and a pyridoxine-deficient diet. The animals were divided at random into four groups: control rats (CR), control diabetic rats (CDR), diabetic rats receiving a pyridoxine-free diet (DRB6), and diabetic rats receiving saline solution...

journal_title：Toxicology mechanisms and methods

authors： Jordao AA,Dos Santos FL,Marchini JS,Vannucchi H

更新日期：2007-01-01 00:00:00

abstract：:The authors have previously shown that high alcohol preference rats (HAP) have a significantly higher sensitivity than low alcohol preference rats (LAP) for methamphetamine (MAP). In this study, changes in dopamine and serotonin release induced by MAP (1 mg/kg, intraperitoneally) after pre-treatment with D1 and D2 rec...

journal_title：Toxicology mechanisms and methods

authors： Nishiguchi M,Kinoshita H,Kasuda S,Takahashi M,Yamamura T,Matsui K,Ouchi H,Minami T,Hishida S,Nishio H

更新日期：2010-03-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) is a highly toxic industrial solvent with pronounced systemic toxicity including brain. Neurotoxicity may be a direct result of hepatic dysfunction from CCl4 intoxication. Over the years CCl4 has been used as an excellent model for studying experimentally induced neurotoxicity in murine mod...

journal_title：Toxicology mechanisms and methods

authors： Naseem M,Parvez S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS:In this study, different concentrations of arsenic w...

journal_title：Toxicology mechanisms and methods

authors： Phan NN,Li KL,Lin YC

更新日期：2018-07-01 00:00:00

abstract：:Fusarium mycotoxin toxicosis has been implicated in the etiology of Keshan disease, an endemic mitochondrial cardiomyopathy prevailing in certain areas of China. Butenolide (4-acetamido-4-hydroxy-2-butenoic acid gamma-lactone) is one of the Fusarium mycotoxins which are frequently detected from cereal grains in endemi...

journal_title：Toxicology mechanisms and methods

authors： Wang YM,Liu JB,Peng SQ

更新日期：2009-02-01 00:00:00

abstract：:Renal disease is a common complication of diabetes mellitus. The pathogenesis of diabetic nephropathy is not well understood, but hyperglycemia seems to be a crucial factor. Recent evidence indicates that the overproduction of reactive oxygen species, observed in both clinical and experimental diabetes, and mitochondr...

journal_title：Toxicology mechanisms and methods

authors： Seiça R,Santos DL,Palmeira CM,Moreno AJ,Sena C,Cunha MF,Santos MS

更新日期：2005-01-01 00:00:00

abstract：:Oxidative stress in biological systems can result in radical-induced lipid peroxidation (LPO), which can lead to the production of secondary reactive by-products such as 4-hydroxy-2-nonenal (HNE), malondialdehyde (MDA), acrolein, and acetaldehyde. These deleterious compounds are known to react with and concomitantly m...

journal_title：Toxicology mechanisms and methods

authors： Rainey RP,Gillman IG,Shi X,Cheng T,Stinson A,Gietl D,Albino AP

更新日期：2009-09-01 00:00:00

abstract：:ABSTRACT The effect of sodium selenite, alpha-tocopherol, and their combination was studied in the hemic system of goat. Incubation of goat blood with selenium and vitamin E for 24 h resulted in a decrease in hemoglobin concentrations in Se-and vitamin E-treated groups, whereas no change in the osmotic fragility was o...

journal_title：Toxicology mechanisms and methods

authors： Saini RK,Saini N,Kataria M,Babu S

更新日期：2007-01-01 00:00:00

abstract：:The advent of the industrial revolution has seen a significant increase in the number of new chemical entities (NCEs) released in the environment. It becomes imperative to check the toxic potential of NCEs to nontarget species before they are released for commercial purposes because some of these may exert genotoxicit...

journal_title：Toxicology mechanisms and methods

authors： Bajpayee M,Pandey AK,Parmar D,Dhawan A

更新日期：2005-01-01 00:00:00

abstract：:Ethanol metabolism is accompanied by generation of free radicals that damage cell components, especially lipids. The present study was designed to investigate the efficacy of the preventive effect of black tea on the lipid oxidative modifications in different tissues (plasma, liver, brain, kidney, stomach, lung, intes...

journal_title：Toxicology mechanisms and methods

authors： Luczaj W,Welerowicz T,Skrzydlewska E,Buszewski B

更新日期：2008-07-01 00:00:00

abstract：:For good performance in clinical and forensic toxicology, it is important to be aware of the signs and symptoms related to xenobiotic exposure since they will assist clinicians to reach a useful and rapid diagnosis. This manuscript highlights and critically analyses clinical and forensic imaging related to ethanol abu...

journal_title：Toxicology mechanisms and methods

authors： Dinis-Oliveira RJ,Magalhães T,Moreira R,Proença JB,Pontes H,Santos A,Duarte JA,Carvalho F

更新日期：2014-02-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) activity is used widely as a biomarker for tumor promotion in animal model systems. Several previous studies have reported increases in ODC activity in tissues of rats exposed to 60 Hz magnetic fields. The goals of this study were to confirm these findings and to determine whether ODC act...

journal_title：Toxicology mechanisms and methods

authors： McDonald LJ,Loberg LI,McCormick DL,Gauger JR,Savage RE Jr,Zhu H,Lotz WG,Mandeville R,Owen RD,Cress LW,Desta AB

更新日期：2003-01-01 00:00:00

abstract：:Chlorpyrifos (CPF) is one of the organophosphorus pesticides widely used around the world, especially in China. Acetylcholinesterase inhibition is the main effect of organophosphorus insecticides exposure. Studies showed that CPF may also interfere with the metabolism of monoamine transmitters. To investigate the effe...

journal_title：Toxicology mechanisms and methods

authors： Xu F,Chang X,Lou D,Wu Q,Zhou Z

更新日期：2012-05-01 00:00:00

abstract：AIM:Nicotine exerts a number of physiological effects. The purpose of this study was to determine the effects of nicotine on thioacetamide (TAA)-induced liver fibrosis in mice. MATERIALS AND METHODS:For in vivo experiments, hepatic fibrosis was induced by TAA (0.25 g/kg, i.p.) three times a week for 6 weeks. Mice of T...

journal_title：Toxicology mechanisms and methods

authors： Zhou Z,Park S,Kim JW,Zhao J,Lee MY,Choi KC,Lim CW,Kim B

更新日期：2017-09-01 00:00:00

abstract：:We investigated the effect of two extracts from Peruvian plants given alone or in a mixture on sperm count and glycemia in streptozotocin-diabetic mice. Normal or diabetic mice were divided in groups receiving vehicle, black maca (Lepidium meyenii), yacon (Smallanthus sonchifolius) or three mixtures of extracts black ...

journal_title：Toxicology mechanisms and methods

authors： Gonzales GF,Gonzales-Castañeda C,Gasco M

更新日期：2013-09-01 00:00:00

abstract：:The objective of this study was to examine the toxicity of 1-(4-morpholinophenyl)-3-(4-fluorophenyl)-propenone (A) and 1-(4-morpholinophenyl)-3-(3-fluorophenyl)-propenone (B) on Spodoptera frugiperda (Sf9) cells and the mechanism of the toxicity. By cell-based thiazolyl blue tetrazolium bromide (MTT) assay, we found t...

journal_title：Toxicology mechanisms and methods

authors： Zhang X,Tao K,Hou T

更新日期：2012-05-01 00:00:00

abstract：:Despite the increasing use of amorphous silica nanoparticles (SNPs) in biomedical applications, their toxicity after intravenous administration remains a major concern. We investigated the effects of single 7 mg/kg intravenous infusions of 13 nm SNPs on hemodynamic parameters in rats. Hematological and biochemical par...

journal_title：Toxicology mechanisms and methods

authors： Zhuravskii S,Yukina G,Kulikova O,Panevin A,Tomson V,Korolev D,Galagudza M

更新日期：2016-05-01 00:00:00

abstract：:During the last years, much attention was focused on the measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a marker of oxidative DNA damage. Among various analytical techniques, the (32)P-postlabeling assay has been applied in determination of 8-oxo-dG. However, artefactual DNA oxidation could take plac...

journal_title：Toxicology mechanisms and methods

authors： Maatouk I,Bouaïcha N,Plessis MJ,Périn F

更新日期：2006-01-01 00:00:00

abstract：:Some environmental pollutants derived from industrial processes have been suggested to be responsible for neurological impairment in children, especially in heavily polluted areas. Since these compounds are usually activators of aryl hydrocarbon receptor (AhR), it would be important to better understand the molecular ...

journal_title：Toxicology mechanisms and methods

authors： Imran S,Ferretti P,Vrzal R

更新日期：2015-01-01 00:00:00

abstract：:In pregnancy, opioids may be used medically and also misused. We hypothesized that the umbilical cord (UC) could be a good screening tool for determining opioid exposure and improving medical care. One hundred and one UC, each with 50 associated ICD9/ICD10 codes were used. Using predictive pharmacokinetic analysis we ...

journal_title：Toxicology mechanisms and methods

authors： Knight SJ,Smith AD,Wright TE,Collier AC

更新日期：2019-01-01 00:00:00

abstract：:The implications of delta-aminolevulinic acid dehydratase (ALAD) polymorphism for lead kinetics and toxicity have been mainly studied in occupationally exposed adults. Therefore, our purpose was to evaluate the distribution of ALAD genotype and its association with biomarkers of exposure (PbB levels) and effect (Blood...

journal_title：Toxicology mechanisms and methods

authors： Mijares IA,López P,Rosado JL,Cebrián A,Vera-Aguilar E,Alatorre J,Quintanilla-Vega MB,García AE,Stoltzfus RJ,Cebrián ME,García-Vargas GG

更新日期：2006-01-01 00:00:00

abstract：:Xysmalobium undulatum (Uzara) is one of the most widely used indigenous traditional herbal remedies in Southern Africa. Commercially available Uzara plant material was used to prepare a crude aqueous extract, of which the toxicity potential was investigated in the hepatic HepG2/C3A cell line in both traditional two-di...

journal_title：Toxicology mechanisms and methods

authors： Calitz C,Hamman JH,Viljoen AM,Fey SJ,Wrzesinski K,Gouws C

更新日期：2018-11-01 00:00:00

abstract：:ABSTRACT Although copper is an essential metal and cadmium is an environmental pollutant, both are toxic when present in excess. Metallothionein and glutathione are two of the key components that participate in detoxification of copper and cadmium. In the present study the role of glutathione in resistance to copper a...

journal_title：Toxicology mechanisms and methods

authors： Bi WX,Kong F,Hu XY,Cui X

更新日期：2007-01-01 00:00:00

abstract：CONTEXT:Although the liver is the primary target organ in acetaminophen (APAP) toxicity, other organs are affected. Previous data suggested that chronic APAP abuse can be ototoxic and the mechanism involves APAP-induced oxidative stress and reactive metabolite (N-acetyl-p-benzoquinone imine, NAPQI)-induced endoplasmic ...

journal_title：Toxicology mechanisms and methods

authors： McGill MR,Kennon-McGill S,Durham D,Jaeschke H

更新日期：2016-02-01 00:00:00

abstract：:In the present investigation acetylcholinesterase (AChE) was estimated in erythrocytes from blood samples exposed to four commonly used organophosphorus pesticides in vitro. The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitor...

journal_title：Toxicology mechanisms and methods

authors： Das GP,Jamil K,Rahman MF

更新日期：2006-01-01 00:00:00

abstract：:In recent years, diabetes and its associated complications have come to represent a major public health concern. It is a complex disease characterized by multiple metabolic derangements and is known to impair cardiac function by disrupting the balance between pro-oxidants and antioxidants at the cellular level. The su...

journal_title：Toxicology mechanisms and methods

authors： Selvaraju V,Joshi M,Suresh S,Sanchez JA,Maulik N,Maulik G

更新日期：2012-06-01 00:00:00

abstract：:Allergic rhinitis (also known as hay fever) is the most commonly occurring immunological disorder, and it affects 40 million men, women, and children in the United States. Symptomatically, it is an inflammation and irritation of the mucous membranes that line the nose. Allergy is defined as a state of hypersensitivity...

journal_title：Toxicology mechanisms and methods

authors： Amit A,Saxena VS,Pratibha N,Bagchi M,Bagchi D,Stohs SJ

更新日期：2003-01-01 00:00:00

abstract：:Tumor progression is the continual selection of variant subpopulations of malignant cells that have acquired increasing levels of genetic instability (Nowell Science 1976, 194, 23-28). This instability is manifested as chromosomal aneuploidy or translocations, viral integration or somatic mutations that typically affe...

journal_title：Toxicology mechanisms and methods

authors： Huppi K,Pitt J,Wahlberg B,Caplen NJ

更新日期：2011-05-01 00:00:00

abstract：:The β-glucans (β-G) are polysaccharides produced by various organisms, and sulfation of β-G renders them more soluble. With the objective to assess the effects of sulfated and non-sulfated β-G extracted from Agaricus brasiliensis in MCF-7 cells, assays were used to evaluate cytotoxicity, genotoxicity, cell proliferati...

journal_title：Toxicology mechanisms and methods

authors： Baranoski A,Tempesta Oliveira M,Semprebon SC,Niwa AM,Ribeiro LR,Mantovani MS

更新日期：2015-01-01 00:00:00