Abstract:
:Chlorpyrifos (CPF) is one of the organophosphorus pesticides widely used around the world, especially in China. Acetylcholinesterase inhibition is the main effect of organophosphorus insecticides exposure. Studies showed that CPF may also interfere with the metabolism of monoamine transmitters. To investigate the effects of CPF on dopaminergic pathway, the dopamine content, gene expression of catechol-O-methyl- transferase (COMT), vesicular monoamine transporter-2 (VMAT-2), and monoamine oxidase (MAO) and its activity in PC12 cells exposed to CPF was determined. Results showed that cell viability was decreased and total dopamine concentration was increased with CPF administration in a dose-dependent pattern. Gene of MAO was significantly downregulated in PC12 cells, while genes of COMT and VMAT-2 in PC12 cells did not show any change after CPF exposure. The MAO activity was decreased following incubation exposed to CPF. These results suggest that CPF may interfere with dopaminergic pathway through inhibition on gene and protein expression of MAO in vitro.
journal_name
Toxicol Mech Methodsjournal_title
Toxicology mechanisms and methodsauthors
Xu F,Chang X,Lou D,Wu Q,Zhou Zdoi
10.3109/15376516.2012.657260subject
Has Abstractpub_date
2012-05-01 00:00:00pages
309-14issue
4eissn
1537-6516issn
1537-6524journal_volume
22pub_type
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journal_title:Toxicology mechanisms and methods
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doi:10.1080/15376510601091392
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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abstract:BACKGROUND:Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS:In this study, different concentrations of arsenic w...
journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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abstract::Cadmium is one of the most toxic elements to which man can be exposed at work or in the environment. By far, the most salient toxicological property of Cd is its exceptionally long half-life in the human body. Once absorbed, Cd accumulates in the human body, particularly in the liver and other vital organs. The cellul...
journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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journal_title:Toxicology mechanisms and methods
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