Abstract:
:Tumor progression is the continual selection of variant subpopulations of malignant cells that have acquired increasing levels of genetic instability (Nowell Science 1976, 194, 23-28). This instability is manifested as chromosomal aneuploidy or translocations, viral integration or somatic mutations that typically affect the expression of a gene (oncogene) that is especially damaging to the proper function of a cell. With the recent discovery of non-coding RNAs such as microRNAs (miRNAs), the concept that a target of genetic instability must be a protein-encoding gene is no longer tenable. Over the years, we have conducted several studies comparing the location of miRNA genes to positions of genetic instability, principally retroviral integration sites and chromosomal translocations in the mouse as a means of identifying miRNAs of importance in carcinogenesis. In this current study, we have used the most recent annotation of the mouse miRome (miRBase, release 16.0), and several datasets reporting the sites of integration of different retroviral vectors in a variety of mouse strains and mouse models of cancer, including for the first time a model that shows a propensity to form solid tumors, as a means to further identify or define, candidate oncogenic miRNAs. Several miRNA genes and miRNA gene clusters stand out as interesting new candidate oncogenes due to their close proximity to common retroviral integration sites including miR-29a/b/c and miR106a~363. We also discussed some recently identified miRNAs including miR-1965, miR-1900, miR-1945, miR-1931, miR-1894, and miR-1936 that are close to common retroviral integration sites and are therefore likely to have some role in cell homeostasis.
journal_name
Toxicol Mech Methodsjournal_title
Toxicology mechanisms and methodsauthors
Huppi K,Pitt J,Wahlberg B,Caplen NJdoi
10.3109/15376516.2011.562759subject
Has Abstractpub_date
2011-05-01 00:00:00pages
325-33issue
4eissn
1537-6516issn
1537-6524journal_volume
21pub_type
杂志文章,评审abstract::The titanium nitride coated titanium is a material intended for the fabrication of left ventricular assist device. As per International standards, a material is subjected to pre-clinical evaluation before fabrication of a device. Toxicity/biocompatibility studies such as acute systemic toxicity, intracutaneous irritat...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2011.610384
更新日期:2012-02-01 00:00:00
abstract::ABSTRACT When two toxicants overtly producing similar effects are given together, the effect of the combination may either be equal to the algebraic sum of their individual effects or may be more than or less than the algebraic sum of their individual effects. Therefore, to ascertain the nature of interaction precisel...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376510601177654
更新日期:2007-01-01 00:00:00
abstract::Several deleterious effects of Tramadol including deaths were reported especially when used in large doses. Being metabolized mainly in the liver, Tramadol have serious hepatotoxic effects. This study investigates the effect of vitamin E on Tramadol-induced hepatotoxicity in rats by evaluating the antioxidant biochemi...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376516.2019.1681043
更新日期:2020-03-01 00:00:00
abstract::Toxicogenomics has evolved into a useful technique for providing greater mechanistic insights into adverse effects that will spur the development of novel approaches for identifying and understanding toxicity issues. The ability to capture a snapshot of the transcriptome at any given time during the development of an ...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376520600558317
更新日期:2006-01-01 00:00:00
abstract::The β-glucans (β-G) are polysaccharides produced by various organisms, and sulfation of β-G renders them more soluble. With the objective to assess the effects of sulfated and non-sulfated β-G extracted from Agaricus brasiliensis in MCF-7 cells, assays were used to evaluate cytotoxicity, genotoxicity, cell proliferati...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2015.1043762
更新日期:2015-01-01 00:00:00
abstract::The metabolism of aromatic hydrocarbons by the organism forms products that cause cell death depending on the type of exposure. Benzene exposure has been linked to oxidative stress, hepatic damage, aplastic anemia, and hematopoietic cancer as lymphoid and myeloid leukemia. However, there are not fast methods to evalua...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376516.2018.1455786
更新日期:2018-07-01 00:00:00
abstract::The effects of chlorpyrifos and fenvalerate on the activity of the cellulase, superoxide dismutase (SOD) and catalase (CAT) of the earthworm (Eisenia foetida) were studied. Earthworms were exposed to chlorpyrifos and fenvalerate at a final concentration of 10, 20, and 40 mg/kg dry soil, respectively. Tissues from each...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2011.640718
更新日期:2012-04-01 00:00:00
abstract:CONTEXT:Over expression of renin-angiotensin system (RAS) and nuclear factor-kappaB (NF-κB) has a major role in many cancers. It has been suggested that some angiotensin receptor blockers (ARBs) could reduce the proliferation of cancer cells. The role of NF-κB pathway has been documented in cell proliferation. OBJECTI...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2015.1053647
更新日期:2015-01-01 00:00:00
abstract::Nematode Caenorhabditis elegans (C. elegans) was used to investigate the impact of silver nanoparticles (SNP), multiwalled carbon nanotubes (MWCNT), and polyamidoamine dendrimers (PAMAM) used in concentration of 1010 particle/mL. Population-based observations and gene expression analysis were employed in this study. S...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376516.2018.1449277
更新日期:2018-07-01 00:00:00
abstract::Reported myocardial pathology resulting from increased levels of catecholamines in vivo has led us to investigate the effect of adrenalin on the gap junction proteins connexin 40 (Cx40) and Cx43 and the possible relationship to vascular toxicity. Adrenalin and its known metabolites, adrenochrome and adrenolutin, were ...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376520600632039
更新日期:2006-01-01 00:00:00
abstract::Benzo(a)pyrene (BaP) was a well-known environmental pollutant, numerous studies had implicated BaP as a causative agent in human cancer, particularly lung cancer. The lemongrass essential oil (LEO) possessed various pharmacological activities, especially the anti-oxidative stress and cancer prevention. In the current ...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376516.2016.1266541
更新日期:2017-02-01 00:00:00
abstract::Histone deacetylase 2 (HDAC2), a prominent member of the class I HDAC family, plays crucial roles in inflammation and other pathological processes. Recent studies have found that the activity and expression of HDAC2 were altered under oxidative stress conditions. The aim of the current study was to elucidate the expre...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2012.716091
更新日期:2012-10-01 00:00:00
abstract::In this study, the preventive effects of NGF against colistin-induced autophagy and apoptosis in PC12 cells have been investigated. Fluorescence microscopy, real-time PCR, transmission electron microscopy (TEM), flow cytometery, and western blotting technique were used. The results showed that large amounts of autopha...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376516.2018.1534298
更新日期:2019-03-01 00:00:00
abstract::Some environmental pollutants derived from industrial processes have been suggested to be responsible for neurological impairment in children, especially in heavily polluted areas. Since these compounds are usually activators of aryl hydrocarbon receptor (AhR), it would be important to better understand the molecular ...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2015.1070227
更新日期:2015-01-01 00:00:00
abstract::The present study was designed to investigate the effects of aqueous Azadirchta Indica leaf extract (AAILE) on serum glycoprotein contents and tumor incidence rate in colon of rats subjected to Dimethylhydrazine (DMH) treatment. Forty rats were divided equally and randomly into four groups viz., Group I (normal contro...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376510802646523
更新日期:2009-05-01 00:00:00
abstract::Crotonaldehyde is a hazardous pollutant present in cigarette smoke and automobile exhausts that is generated by lipid peroxidation, and harmful to reproductive organs. Although we are often exposed to low doses of crotonaldehyde daily, its adverse effects on the reproductive organs have not been fully elucidated. To e...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376516.2019.1646369
更新日期:2020-01-01 00:00:00
abstract::Chlorpyrifos (CPF) is one of the organophosphorus pesticides widely used around the world, especially in China. Acetylcholinesterase inhibition is the main effect of organophosphorus insecticides exposure. Studies showed that CPF may also interfere with the metabolism of monoamine transmitters. To investigate the effe...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2012.657260
更新日期:2012-05-01 00:00:00
abstract::The US military has placed major emphasis on developing therapeutics against nerve agents (NA). Current efforts are hindered by the lack of effective in vitro cellular models to aid in the preliminary screening of potential candidate drugs/antidotes. The development of an in vitro cellular model to aid in discovering ...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2014.943442
更新日期:2014-10-01 00:00:00
abstract::The CD1-haired mouse and the SKH-hairless mouse are two animal models that have been used to evaluate sulfur mustard (HD) exposure and protection in our laboratory. In a recent study we observed that a substance P inhibitor protected the haired mouse ear against an HD solution, but the same drug was not successful in ...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376520208951165
更新日期:2002-01-01 00:00:00
abstract::The advent of the industrial revolution has seen a significant increase in the number of new chemical entities (NCEs) released in the environment. It becomes imperative to check the toxic potential of NCEs to nontarget species before they are released for commercial purposes because some of these may exert genotoxicit...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376520590945667
更新日期:2005-01-01 00:00:00
abstract::The specific properties of silver nanoparticles (AgNPs), such as antimicrobial activity and electrical conductivity, allow them to be used in many fields. However, their expanding application is also raising health, environmental and safety concerns. Previous in vivo AgNP toxicity studies have indicated a gender-diffe...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2013.780196
更新日期:2013-07-01 00:00:00
abstract::The aim of this work was to characterize inner mitochondrial membrane channels permeable to calcium cations (Ca(++)). Mitochondrial membranes isolated from rat heart were incorporated into the bilayer lipid membrane, and single Ca(++) channel currents were measured. The observed channels were selective for Ca(++) and ...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376520490257428
更新日期:2004-01-01 00:00:00
abstract::Carfilzomib (CFZ) is an inhibitor of proteasome that is generally used in the treatment of multiple myeloma but due to its cardiotoxicity clinical use may be limited. Dexrazoxane (DZR), an inhibitor of topoisomerase-II, prevents cardiac damage by reducing the formation of reactive oxygen species and hypertrophic gene ...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2016.1143071
更新日期:2016-01-01 00:00:00
abstract::Misuse of various chemicals, such as chemical warfare agents, industrial chemicals or pesticides during warfare or terrorists attacks requires adequate protection. Thus, development and evaluation of novel decontamination dispositives and techniques are needed. In this study, in vitro permeation and decontamination of...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2012.686535
更新日期:2012-09-01 00:00:00
abstract::For good performance in clinical and forensic toxicology, it is important to be aware of the signs and symptoms related to xenobiotic exposure since they will assist clinicians to reach a useful and rapid diagnosis. This manuscript highlights and critically analyses clinical and forensic imaging related to ethanol abu...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章,评审
doi:10.3109/15376516.2013.869782
更新日期:2014-02-01 00:00:00
abstract::How triptolide is associated with mitochondrial dysfunction and apoptosis in connection with its hepatotoxicity remains unclear. The objective of our study was to find out the link between mitochondrial dynamics and cell death in triptolide induced hepatotoxicity. We treated L02 cells with 25 nM concentration of tript...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376516.2019.1669247
更新日期:2020-02-01 00:00:00
abstract::ABSTRACT The ideal toxicity biomarker is composed of the properties of prediction (is detected prior to traditional pathological signs of injury), accuracy (high sensitivity and specificity), and mechanistic relationships to the endpoint measured (biological relevance). Gene expression-based toxicity biomarkers ("sign...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376510701857072
更新日期:2008-01-01 00:00:00
abstract::Up to now, the ability of target cells to activate protein kinase C (PKC) and protein kinase D (PKD) (which is often a downstream target of PKC) has not been examined in natural killer (NK) lymphocytes. Here we examined whether exposure of human NK cells to lysis sensitive tumor cells activated PKC and PKD. The result...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.3109/15376516.2015.1070226
更新日期:2015-01-01 00:00:00
abstract::ABSTRACT Male Wistar rats with streptozotocin-induced diabetes received a control diet and a pyridoxine-deficient diet. The animals were divided at random into four groups: control rats (CR), control diabetic rats (CDR), diabetic rats receiving a pyridoxine-free diet (DRB6), and diabetic rats receiving saline solution...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章
doi:10.1080/15376510601003744
更新日期:2007-01-01 00:00:00
abstract::In recent years, diabetes and its associated complications have come to represent a major public health concern. It is a complex disease characterized by multiple metabolic derangements and is known to impair cardiac function by disrupting the balance between pro-oxidants and antioxidants at the cellular level. The su...
journal_title:Toxicology mechanisms and methods
pub_type: 杂志文章,评审
doi:10.3109/15376516.2012.666648
更新日期:2012-06-01 00:00:00