Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice.

abstract：:The implications of delta-aminolevulinic acid dehydratase (ALAD) polymorphism for lead kinetics and toxicity have been mainly studied in occupationally exposed adults. Therefore, our purpose was to evaluate the distribution of ALAD genotype and its association with biomarkers of exposure (PbB levels) and effect (Blood...

journal_title：Toxicology mechanisms and methods

authors： Mijares IA,López P,Rosado JL,Cebrián A,Vera-Aguilar E,Alatorre J,Quintanilla-Vega MB,García AE,Stoltzfus RJ,Cebrián ME,García-Vargas GG

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The objective of the present study is to evaluate the antihyperlipidemic effect of Chlorella pyrenoidosa in diabetic rats exposed to cadmium (Cd). MATERIALS AND METHODS:Group 1 and 2 rats were treated as control and C. pyrenoidosa control. Group 3 and 4 rats were given single injection of streptozotocin (40 ...

journal_title：Toxicology mechanisms and methods

authors： Senthilkumar T,Sangeetha N,Ashokkumar N

更新日期：2012-10-01 00:00:00

abstract：:ABSTRACT Although copper is an essential metal and cadmium is an environmental pollutant, both are toxic when present in excess. Metallothionein and glutathione are two of the key components that participate in detoxification of copper and cadmium. In the present study the role of glutathione in resistance to copper a...

journal_title：Toxicology mechanisms and methods

authors： Bi WX,Kong F,Hu XY,Cui X

更新日期：2007-01-01 00:00:00

abstract：:The present study was designed to investigate the effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats. Sprague-Dawley rats were subcutaneously injected with isoproterenol (20 mg/kg). Cardiac marker enzymes in serum, antioxidative parameters and inflammatory...

journal_title：Toxicology mechanisms and methods

authors： Gai Y,Ma Z,Yu X,Qu S,Sui D

更新日期：2012-10-01 00:00:00

abstract：:Silver and gold nanoparticles (Ag-AuNPs) are currently some of the most manufactured nanomaterials. Accordingly, the hazards associated with human exposure to Ag-AuNPs should be investigated to facilitate the risk assessment process. In particular, because pulmonary exposure to Ag-AuNPs occurs during handling of these...

journal_title：Toxicology mechanisms and methods

authors： Ávalos A,Haza AI,Mateo D,Morales P

更新日期：2015-01-01 00:00:00

abstract：:ABSTRACT Oxidative damage to cellular constituents is one of the major mechanisms of alcoholic liver injury, and administration of antioxidants ameliorates alcoholic liver disease. The present study investigated the influence of (-) epigallocatechin gallate (EGCG), a major polyphenol component of green tea, on oxidant...

journal_title：Toxicology mechanisms and methods

authors： Kaviarasan S,Sundarapandiyan R,Anuradha CV

更新日期：2008-01-01 00:00:00

abstract：:Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, is widely used for the treatment of different types of seizures and myoclonic epilepsy. Several mechanisms have been suggested for VPA hepatotoxicity, and most of them are associated with oxidative stress. It seems that oxidative stress by VPA treatment...

journal_title：Toxicology mechanisms and methods

authors： Jafarian I,Eskandari MR,Mashayekhi V,Ahadpour M,Hosseini MJ

更新日期：2013-10-01 00:00:00

abstract：:Misuse of various chemicals, such as chemical warfare agents, industrial chemicals or pesticides during warfare or terrorists attacks requires adequate protection. Thus, development and evaluation of novel decontamination dispositives and techniques are needed. In this study, in vitro permeation and decontamination of...

journal_title：Toxicology mechanisms and methods

authors： Misik J,Pavlikova R,Josse D,Cabal J,Kuca K

更新日期：2012-09-01 00:00:00

abstract：:Mitochondrial haplogroups can differ in frequency of occurrence in those who are 100 years old and in the rest of the population. These differences are not universally observed; moreover, they are population-specific. We analyzed the haplogroups in 97 Polish 100-year-olds and compared them with those of more than 145 ...

journal_title：Toxicology mechanisms and methods

authors： Lorenc A,Tonska K,Kabzinska D,Bartnik E

更新日期：2004-01-01 00:00:00

abstract：:Oral cocaine administration results in hepatic necrosis, increased plasma transaminase concentration, and decreased antioxidative capability, which is potentiated by lipopolysaccharide (LPS) in male CF-1 mice. Females administered the same treatment regimen display none of the hepatotoxic effects seen in their male co...

journal_title：Toxicology mechanisms and methods

authors： Visalli T,Turkall R,Abdel-Rahman MS

更新日期：2005-01-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) is a highly toxic industrial solvent with pronounced systemic toxicity including brain. Neurotoxicity may be a direct result of hepatic dysfunction from CCl4 intoxication. Over the years CCl4 has been used as an excellent model for studying experimentally induced neurotoxicity in murine mod...

journal_title：Toxicology mechanisms and methods

authors： Naseem M,Parvez S

更新日期：2014-10-01 00:00:00

abstract：:In this study, the preventive effects of NGF against colistin-induced autophagy and apoptosis in PC12 cells have been investigated. Fluorescence microscopy, real-time PCR, transmission electron microscopy (TEM), flow cytometery, and western blotting technique were used. The results showed that large amounts of autopha...

journal_title：Toxicology mechanisms and methods

authors： Tian E,Hu W,Miao Y,Muhammad I,Zhang L,Xia C,Ding L,Zhang Q,Li R,Chen C,Li J

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The potential toxicity resulting from the possible interactions of the herbicides, Ultrazin (atrazine, ATZ) and Bretmont Wipeout (glyphosate, GLY) (as commercialized in Nigeria), is not completely known. We therefore evaluated reproductive- and hepato-toxicity in rats co-exposed to ATZ and GLY. METHODS:Six ...

journal_title：Toxicology mechanisms and methods

authors： Abarikwu SO,Akiri OF,Durojaiye MA,Adenike A

更新日期：2015-01-01 00:00:00

abstract：:The study aims at evaluating the combination of the quinocetone and the ML-7 in preclinical hepatocellular carcinoma models. To this end, the effect of quinocetone and ML-7 on apoptosis induction and signaling pathways was analyzed on HepG2 cell lines. Here, we report that ML-7, in a nontoxic concentration, sensitized...

journal_title：Toxicology mechanisms and methods

authors： Zhou Y,Zhang S,Deng S,Dai C,Tang S,Yang X,Li D,Zhao K,Xiao X

更新日期：2016-01-01 00:00:00

abstract：:ABSTRACT The effect of sodium selenite, alpha-tocopherol, and their combination was studied in the hemic system of goat. Incubation of goat blood with selenium and vitamin E for 24 h resulted in a decrease in hemoglobin concentrations in Se-and vitamin E-treated groups, whereas no change in the osmotic fragility was o...

journal_title：Toxicology mechanisms and methods

authors： Saini RK,Saini N,Kataria M,Babu S

更新日期：2007-01-01 00:00:00

abstract：:The brain is a well-organized, yet highly complex, organ in the mammalian system. Most investigators use the whole brain, instead of a selected brain region(s), for biochemical analytes as toxicological endpoints. As a result, the obtained data is often of limited value, since their significance is compromised due to ...

journal_title：Toxicology mechanisms and methods

authors： Gupta RC

更新日期：2004-01-01 00:00:00

abstract：:In pregnancy, opioids may be used medically and also misused. We hypothesized that the umbilical cord (UC) could be a good screening tool for determining opioid exposure and improving medical care. One hundred and one UC, each with 50 associated ICD9/ICD10 codes were used. Using predictive pharmacokinetic analysis we ...

journal_title：Toxicology mechanisms and methods

authors： Knight SJ,Smith AD,Wright TE,Collier AC

更新日期：2019-01-01 00:00:00

abstract：:Concern over the influence of carbon nanotubes (CNTs) on human health has arisen due to advances; however, little is known about the potential toxicity of CNTs. In this study, impurity-free single-wall carbon nanotubes (SWCNTs), with different physical properties in cell culture medium, were prepared by a novel disper...

journal_title：Toxicology mechanisms and methods

authors： Fujita K,Fukuda M,Endoh S,Kato H,Maru J,Nakamura A,Uchino K,Shinohara N,Obara S,Nagano R,Horie M,Kinugasa S,Hashimoto H,Kishimoto A

更新日期：2013-10-01 00:00:00

abstract：:Renal disease is a common complication of diabetes mellitus. The pathogenesis of diabetic nephropathy is not well understood, but hyperglycemia seems to be a crucial factor. Recent evidence indicates that the overproduction of reactive oxygen species, observed in both clinical and experimental diabetes, and mitochondr...

journal_title：Toxicology mechanisms and methods

authors： Seiça R,Santos DL,Palmeira CM,Moreno AJ,Sena C,Cunha MF,Santos MS

更新日期：2005-01-01 00:00:00

abstract：:The present study was designed to investigate the effects of aqueous Azadirchta Indica leaf extract (AAILE) on serum glycoprotein contents and tumor incidence rate in colon of rats subjected to Dimethylhydrazine (DMH) treatment. Forty rats were divided equally and randomly into four groups viz., Group I (normal contro...

journal_title：Toxicology mechanisms and methods

authors： Ramzanighara A,Ezzatighadi F,Rai DV,Dhawan DK

更新日期：2009-05-01 00:00:00

abstract：:Monte Carlo based method by using either SMILES based or combination of SMILES and Graph-based descriptors is an important strategy to build the QSAR/QSTR model for prediction of different biological endpoints. In this study, Monte Carlo based QSTR approach was applied to the dataset of 90 nitroaromatic compounds rela...

journal_title：Toxicology mechanisms and methods

authors： Mondal D,Ghosh K,Baidya ATK,Gantait AM,Gayen S

更新日期：2020-05-01 00:00:00

abstract：CONTEXT:The critical role of CaMKIIδ isoforms in cardiac hypertrophy is well documented. OBJECTIVE:This study was aimed to investigate the possible inhibitory effects of aliskiren (ALS) and/or carvedilol (CAV) on CaMKIIδ isoforms expression in experimental cardiac hypertrophy. MATERIALS AND METHODS:Male Wistar albino...

journal_title：Toxicology mechanisms and methods

authors： Bin-Dayel AF,Abdel Baky NA,Fadda LM,Mohammad RA,Al-Mohanna F

更新日期：2016-02-01 00:00:00

abstract：:How triptolide is associated with mitochondrial dysfunction and apoptosis in connection with its hepatotoxicity remains unclear. The objective of our study was to find out the link between mitochondrial dynamics and cell death in triptolide induced hepatotoxicity. We treated L02 cells with 25 nM concentration of tript...

journal_title：Toxicology mechanisms and methods

authors： Hasnat M,Yuan Z,Ullah A,Naveed M,Raza F,Baig MMFA,Khan A,Xu D,Su Y,Sun L,Zhang L,Jiang Z

更新日期：2020-02-01 00:00:00

abstract：:Due to their exceptional properties, gold nanoparticles (AuNPs) have shown promising medical and technological applications in the treatment of cancer and the development of antimicrobial packaging and time-temperature indicators in the food sector. However, little is known about their cytotoxicity when they come into...

journal_title：Toxicology mechanisms and methods

authors： Mateo D,Morales P,Ávalos A,Haza AI

更新日期：2014-03-01 00:00:00

abstract：:ABSTRACT Male Wistar rats with streptozotocin-induced diabetes received a control diet and a pyridoxine-deficient diet. The animals were divided at random into four groups: control rats (CR), control diabetic rats (CDR), diabetic rats receiving a pyridoxine-free diet (DRB6), and diabetic rats receiving saline solution...

journal_title：Toxicology mechanisms and methods

authors： Jordao AA,Dos Santos FL,Marchini JS,Vannucchi H

更新日期：2007-01-01 00:00:00

abstract：:Oxidative stress has a causative role in ischemic reperfusion-induced cell death. Evidence has shown that metformin is capable to reduce ischemic reperfusion injuries. The current study investigated the effect of metformin on ischemia/reperfusion-induced apoptosis in PC12 cells by evaluation of Bcl-2 family proteins e...

journal_title：Toxicology mechanisms and methods

authors： Mohammad Alizadeh E,Mahdavi M,Jenani Fard F,Chamani S,Farajdokht F,Karimi P

更新日期：2018-10-01 00:00:00

abstract：:Color and geometric characteristics of stained areas in histochemical slides are among the features pathologists assess to evaluate the severity of lesions. In this research, image processing techniques were used to perform objective quantification of these characteristics in images of H&E-stained spleen tissues. A se...

journal_title：Toxicology mechanisms and methods

authors： Liu X,Tan J,Hatem I,Smith BL

更新日期：2004-01-01 00:00:00

abstract：:Owing to their structure and function, low-density lipoproteins (LDLs) are particularly susceptible to the oxidative modifications. To prevent against oxidative modification of LDL, L-carnitine, with endogenous small water-soluble quaternary amine possessing antioxidative properties, was used. The aim of this paper wa...

journal_title：Toxicology mechanisms and methods

authors： Augustyniak A,Stankiewicz A,Skrzydlewska E

更新日期：2008-07-01 00:00:00

abstract：:For good performance in clinical and forensic toxicology, it is important to be aware of the signs and symptoms related to xenobiotic exposure since they will assist clinicians to reach a useful and rapid diagnosis. This manuscript highlights and critically analyses clinical and forensic imaging related to ethanol abu...

journal_title：Toxicology mechanisms and methods

authors： Dinis-Oliveira RJ,Magalhães T,Moreira R,Proença JB,Pontes H,Santos A,Duarte JA,Carvalho F

更新日期：2014-02-01 00:00:00

abstract：:The metabolism of aromatic hydrocarbons by the organism forms products that cause cell death depending on the type of exposure. Benzene exposure has been linked to oxidative stress, hepatic damage, aplastic anemia, and hematopoietic cancer as lymphoid and myeloid leukemia. However, there are not fast methods to evalua...

journal_title：Toxicology mechanisms and methods

authors： Martínez-Rodríguez JL,Gutiérrez-Hernández R,Reyes-Estrada CA,Granados-López AJ,Arcos-Ortega T,López JA

更新日期：2018-07-01 00:00:00