Abstract:
:This study applied broccoli and cauliflower extracts (whole, floret, and stem) to zebrafish larvae in parallel to receive 100 mJ/cm(2) of UVB six times, and recorded their fin malformation phenotypes. Chemopreventive effects of each group, including UVB, whole-, floret-, and stem-extracts of broccoli and cauliflower on fin development were evaluated using Kaplan-Meier analysis, log-rank test, and Cox proportional hazards regression. Results showed that (1) zebrafish fins in the UVB + whole broccoli extract group are 6.20~9.32-times more likely to return to normal fins than ones in the UVB only group, but fins in the UVB + whole cauliflower extract group are only 5.13~11.10-times more likely to recover, indicated that whole broccoli and cauliflower extract had similar chemopreventive ability on fin development; and (2) the broccoli stem has the highest antioxidant capacity among other groups. In conclusion, zebrafish can be used as a system for evaluating the efficacy of other UVB protective compounds.
journal_name
Toxicol Mech Methodsjournal_title
Toxicology mechanisms and methodsauthors
Chen YH,Wen CC,Lin CY,Chou CY,Yang ZS,Wang YHdoi
10.3109/15376516.2010.529191subject
Has Abstractpub_date
2011-01-01 00:00:00pages
63-9issue
1eissn
1537-6516issn
1537-6524journal_volume
21pub_type
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journal_title:Toxicology mechanisms and methods
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