Abstract:
AIMS:To identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling. METHODS:In this study, miRNA profiles were obtained from 37 patients with DLBCLs and 60 patients with reactive lymph nodes, equally distributed according to HCV presence. Germinal centres, from reactive lymph nodes were used as controls. Clinical features at presentation were available for all patients. RESULTS:A set of 52 miRNAs define a signature for HCV-associated DLBCL. Importantly, decreased expression of miR-138-5p and increased expression of miR-147a, miR-147b and miR-511-5p in HCV DLBCL was found to be a poor prognostic factor for HCV-positive DLBCL patients. CONCLUSIONS:These data reveal molecular differences in diffuse DLBCL patients according to HCV presence, potentially useful as novel prognostic or therapeutic biomarkers.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Augello C,Gianelli U,Savi F,Moro A,Bonoldi E,Gambacorta M,Vaira V,Baldini L,Bosari Sdoi
10.1136/jclinpath-2014-202352subject
Has Abstractpub_date
2014-08-01 00:00:00pages
697-701issue
8eissn
0021-9746issn
1472-4146pii
jclinpath-2014-202352journal_volume
67pub_type
杂志文章abstract::Four strains of Corynebacterium diphtheriae were sent to UK participants in the UK National External Microbiological Quality Assessment Scheme, who were asked to examine the strains for toxin production by in vitro methods. Laboratories achieved 162/176 (92%) and 160/175 (91%) correct results with two rapid toxin prod...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.7.796
更新日期:1984-07-01 00:00:00
abstract:AIMS:To assess the clinical efficacy of diagnostic procedures for breast cancer at a teaching hospital using internal auditing tools and quality control measures. METHODS:A retrospective assessment of 500 patients who underwent core needle biopsy (wide-bore needle biopsy; WBN) of palpable or non-palpable breast nodes ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2011-200057
更新日期:2011-10-01 00:00:00
abstract:AIM:To determine the frequency of skip lesions in an unselected series of temporal artery biopsies and compare the results with other series. METHODS:The study was a retrospective review of 102 consecutive temporal artery biopsies taken in a five year period (1992-1997) in one large hospital. RESULTS:35 cases (34.3%)...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.53.2.137
更新日期:2000-02-01 00:00:00
abstract::This article reviews recent information concerning the origin of osteoclasts and the local and systemic regulation of their activity. It appears that much of the environmental responsiveness of osteoclasts is mediated by cells of the osteoblastic lineage, which exert a major influence on the localisation, induction, s...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.38.3.241
更新日期:1985-03-01 00:00:00
abstract::Five hundred and seven strains of bacteria isolated from the urine of patients with significant bacteriuria (more than 10(8) colony-forming units per litre) were tested for sensitivity to co-trimoxazole by the agar diffusion technique. Each organism was tested with a combined disk containing trimethoprim and sulphamet...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.2.199
更新日期:1981-02-01 00:00:00
abstract::Foveolar dysplasia is an uncommon form of dysplasia that is encountered in the stomach and oesophagus in the context of Barrett’s oesophagus. Glands displaying foveolar dysplasia also show architectural abnormalities that are similar to those encountered in adenomatous dysplasia. However, from a cytological point of v...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jclinpath-2014-202600
更新日期:2014-10-01 00:00:00
abstract::One hundred sera from 49 patients with glandular toxoplasmosis were examined by a latex agglutination test, the dye test, an indirect haemagglutination test, and a double antibody sandwich enzyme linked immunosorbent assay (ELISA) for antitoxoplasma IgM. The results support previous findings that the dye test, indirec...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.11.1293
更新日期:1984-11-01 00:00:00
abstract::Aberrations of ribosomal biogenesis have been implicated in several congenital bone marrow failure syndromes, such as Diamond-Blackfan anaemia, Shwachman-Diamond syndrome and Dyskeratosis Congenita. Recent studies have identified haploinsufficiency of RPS14 in the acquired bone marrow disease isolated 5q minus syndrom...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-203093
更新日期:2016-02-01 00:00:00
abstract::Enteroviruses are rare causes of acute focal encephalitis. A fatal case of echovirus type 9 infection is reported in a 9 month old boy who presented with a fever and a macular rash followed by two focal seizures. Echovirus type 9 was isolated from lung tissue after seven days. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.9.865
更新日期:1993-09-01 00:00:00
abstract::Aneuploidy is frequently noted in malignant tumours. There is much controversy about its cause and effect in relation to malignant tumours. Failure of the spindle checkpoint caused by mutation of the responsible genes may be one of the important factors for the development of aneuploidy. Telomere dysfunction may also ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2004.018952
更新日期:2004-12-01 00:00:00
abstract::Publications describing aspects of the coccidian protozoan parasite Cryptosporidium, increased greatly during 1983 and 1984 as a result of not only increasing veterinary interest but also in the role of the parasite in the newly recognised acquired immune deficiency syndrome (AIDS). The reports reflected widespread co...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.38.12.1321
更新日期:1985-12-01 00:00:00
abstract::Gastroblastoma is a rare gastric epitheliomesenchymal biphasic tumour composed of spindle and epithelial cells, reported by Miettinen et al in a series of three cases in 2009. All those cases arose in stomachs of young adults. Neither the epithelial nor the mesenchymal component displayed sufficient atypia to diagnose...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2009.074104
更新日期:2010-03-01 00:00:00
abstract:AIMS:To identify the number and geographical distribution of post mortem examinations performed on HIV infected cadavers; to identify the areas that perform post mortem examinations so that, by invitation and discussion, a national post mortem network could be initiated. METHODS:A nationwide survey of Royal College of...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.12.1076
更新日期:1993-12-01 00:00:00
abstract:AIMS:Periductal angiogenesis in ductal carcinoma in situ is associated with an increased risk of subsequently developing a recurrence. This study aimed to (1) identify the relation between periductal and stromal vascularity and recurrence and (2) determine whether thymidine phosphorylase (TP) is associated with angioge...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.56.12.919
更新日期:2003-12-01 00:00:00
abstract::The cell volumes of mononuclear cells, T lymphocytes, B lymphocytes, and monocytes from the peripheral blood of 20 normal individuals were compared to neoplastic lymphoid cells from 14 patients with chronic lymphocytic leukaemia (CLL), 20 individuals with acute lymphocytic leukaemia (ALL), and 18 cases of non-Hodgkin'...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.10.1083
更新日期:1981-10-01 00:00:00
abstract::The results of using a product of serum thyroxine and triiodothyronine binding coefficient, estimated by simple methods, to give a ;free thyroxine index' in normal women, in pregnant women, and in patients taking oral contraceptives is described. The method is believed to provide a reliable means of assessing thyroid ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.21.6.767
更新日期:1968-11-01 00:00:00
abstract::Four hundred faecal samples, collected at approximately weekly intervals during the first year of life from nine babies, were examined for the presence of viruses. Only nine (2.3%) samples contained a virus detectable by electron microscopy, and on all but one occasion only one type of virus was present and that in sm...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.8.774
更新日期:1980-08-01 00:00:00
abstract::Of the first 250 heart and 35 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 217 heart and 33 heart and lung patients were investigated serologically for evidence of Toxoplasma gondii infection. Six patients acquired primary T gondii in...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.2.194
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND/AIMS:CD10 (CALLA) has recently been reported to be expressed in spindle cell neoplasia, and has been used to differentiate endometrial stromal sarcoma from leiomyoma and leiomyosarcoma. In the breast, myoepithelial cells express CD10, but there are few studies of the expression of CD10 in mammary fibroepithe...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.020917
更新日期:2005-02-01 00:00:00
abstract:AIMS:Traditionally, advanced stage ovarian carcinoma is treated by debulking surgery followed by chemotherapy. However, in some circumstances preoperative chemotherapy may be given before optimal surgical debulking. This study aims to describe the morphological features found in ovarian carcinoma after chemotherapy bec...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.55.1.27
更新日期:2002-01-01 00:00:00
abstract::A case of recurrent intussusception in a 76 year old man associated with vascular proliferation is reported. The initial biopsy specimen showed that ulceration and inflammation were not features. The proliferation was so florid as to point to an angiomatous lesion. At this stage a diagnosis of intussusception was not ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.1.91
更新日期:1993-01-01 00:00:00
abstract::A radioimmunoassay for human growth hormone using activated charcoal is described and its precision, accuracy, and sensitivity are defined. Results are presented for growth hormone measurements in plasma obtained during hypoglycaemia induced with insulin in patients of short stature and during glucose tolerance tests ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.25.9.774
更新日期:1972-09-01 00:00:00
abstract:AIM:To ascertain the views of Scottish hospital laboratory users on aspects of regional and supraregional biochemical services offered by the Institute of Biochemistry at Glasgow Royal Infirmary. METHODS:A questionnaire was circulated asking questions or inviting opinions under various headings, including current patt...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.5.395
更新日期:1994-05-01 00:00:00
abstract:AIM:To evaluate a new enzyme immunoassay (EIA) method for detection of Clostridium difficile toxin by comparing it to cytotoxicity assay. To investigate the nature of false negative and false positive EIA results by evaluating clinical and therapeutic parameters. METHODS:737 consecutive diarrhoeal specimens collected ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.50.12.996
更新日期:1997-12-01 00:00:00
abstract::This review of the histomorphometry of bone outlines methods of biopsy and processing of specimens in the laboratory, the basic principles of morphometry, and the measurements made in order to obtain estimates of the proportional volumes and surfaces occupied by different components of bone. Variability such as that b...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.36.12.1323
更新日期:1983-12-01 00:00:00
abstract::In a post-mortem analysis of 1,500 patients, aged 70 years or more, heart disease and malignancy were the two major causes of death. Coronary disease was exceedingly prevalent, almost one in five being subject to this form of heart disease, and 13% dying from its effects. The levelling of the sex ratio in coronary dis...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.16.6.532
更新日期:1963-11-01 00:00:00
abstract:AIMS:To compare the expression of immunohistochemical variables between benign and malignant components of malignant peripheral nerve sheath tumour (MPNST) arising within neurofibroma. METHODS:Eight cases of MPNST arising within a neurofibroma, associated with neurofibromatosis type 1 (NF1), were studied. The areas of...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.54.8.631
更新日期:2001-08-01 00:00:00
abstract:AIM:To determine whether sampling the anterior and posterior cervical lips in hysterectomy specimens provides the best opportunity for detecting unsuspected cervical intraepithelial neoplasia (CIN). METHODS:The frequency with which CIN was identified at a range of positions on the anterior and posterior lips and left ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.4.323
更新日期:1995-04-01 00:00:00
abstract::The performance of coagulometers in the National Quality Assessment Scheme (NEQAS) surveys of the prothrombin time conducted between 1986 and 1987 was reviewed. There were sufficient data for analysis for eight types of coagulometer used with a single type of thromboplastin reagent and one instrument with an alternati...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.1.97
更新日期:1989-01-01 00:00:00
abstract::Lymphoid tissue of the endometrium was analysed by histological, immunohistological, and electron microscopical methods in 10 healthy uteri. A panel of monoclonal antibodies recognising macrophages (OKMI), HLA-DR antigen, B lymphocytes, T lymphocytes and their subsets, and dendritic reticulum cells was used in a two s...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.6.644
更新日期:1985-06-01 00:00:00