Abstract：
:Publications describing aspects of the coccidian protozoan parasite Cryptosporidium, increased greatly during 1983 and 1984 as a result of not only increasing veterinary interest but also in the role of the parasite in the newly recognised acquired immune deficiency syndrome (AIDS). The reports reflected widespread collaboration, not only between clinicians, microbiologists, and histopathologists, but also between veterinary and human health care workers. Cryptosporidium was first described in mice in 1907 and subsequently in various other species; it was not described in man until 1976. Several likely putative species have been described, but there is probably little host specificity. Experimental and clinical studies have greatly increased the knowledge about the organism's biology. The parasite undergoes its complete life cycle within the intestine, although it may occasionally occur in other sites. The main symptom produced is a non-inflammatory diarrhoea, which, in patients with AIDS and children in Third World countries, may be life threatening: even in immunocompetent subjects this symptom is usually protracted. Attempts to find effective chemotherapeutic agents have been unsuccessful. Epidemiologically the infection was thought to be zoonotic in origin, but there is increasing evidence of person to person transmission. Diagnosis has depended upon histological examination, but simple methods of detection have now been described: more invasive methods need no longer be used. The parasite, which is found more commonly in children, occurs in about 2% of faecal specimens examined and seems to be closely associated with production of symptoms. A serological response has been shown. Much remains to be learned about its epidemiology and pathogenic mechanisms, while the expected increase in incidence of AIDS makes an effective form of treatment essential.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Casemore DP,Sands RL,Curry Adoi
10.1136/jcp.38.12.1321subject
Has Abstractpub_date
1985-12-01 00:00:00pages
1321-36issue
12eissn
0021-9746issn
1472-4146journal_volume
38pub_type
杂志文章,评审abstract：:A patient is described in whom a campylobacter enteritis closely resembled ulcerative colitis on clinical, sigmoidoscopic, and histological grounds. Selective stool culture techniques may be necessary to differentiate campylobacter colitis from ulcerative colitis proper. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.10.986
更新日期：1979-10-01 00:00:00
abstract：AIM:To investigate serum placental-type alkaline phosphatase (PLAP-type) activities in women with squamous and glandular malignancies of the reproductive tract using an immunoradiometric assay. METHODS:PLAP-type immunoreactivity was measured in 180 women with non-ovarian malignancies of the reproductive tract and the ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.11.1035
更新日期：1994-11-01 00:00:00
abstract：:Zygomycosis is not often diagnosed in the United Kingdom, and so the possible importance of the findings in a patient with disseminated zygomycosis who had been treated with chemotherapy for erythroleukaemia was not appreciated until histological examination of specimens obtained at necropsy provided a presumptive dia...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.9.1039
更新日期：1985-09-01 00:00:00
abstract：:Laribacter hongkongensis is a Gram-negative, facultative anaerobic, motile, S-shaped, urease-positive bacillus associated with invasive infections in liver cirrhosis patients and community-acquired gastroenteritis. Most cases of L hongkongensis infections occur in eastern countries. Information is lacking on the usefu...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2013-201651
更新日期：2013-12-01 00:00:00
abstract：:Two cases of anticonvulsant megaloblastic anaemia are described, showing features of unusual interest. Though both cases were apparently deficient in folic acid, the Figlu tests were negative. One patient had an extremely low serum B(12) concentration apparently associated with defective B(12) absorption due to defici...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.18.5.593
更新日期：1965-09-01 00:00:00
abstract：:Pre-eclampsia complicated by deep jaundice occurred in a previously healthy primigravida. The main aetiological factor was disseminated intravascular coagulation; this caused both haemolysis and liver cell necrosis. Liver biopsy showed fibrin thrombi in the capillaries with microhaemorrhages and loss of periportal liv...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.30.3.212
更新日期：1977-03-01 00:00:00
abstract：:The results have been compared of microbiological and radioisotope dilution (RID) assay of serum vitamin B12 by participants in national interlaboratory trials in Britain. There was wide variation between the individual participants, especially marked in the L. leichmannii microbiological assay and in the RID methods,...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.33.3.243
更新日期：1980-03-01 00:00:00
abstract：AIMS:To evaluate an antigen capture enzyme linked immunosorbent assay (ELISA) which detects a carbohydrate epitope on the excretory-secretory (ES) antigens of Toxocara canis in clinical practice. METHODS:Serum specimens from healthy adults, patients with acute visceral larva migrans, ocular and inactive toxocariasis, ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.46.6.551
更新日期：1993-06-01 00:00:00
abstract：:Thirteen meningiomas of varying light microscopic features were studied immunohistologically using a panel of monoclonal antibodies directed against epithelial, mesenchymal, and neural components. All 13 meningiomas showed expression of epithelial membrane antigen, vimentin, and S100 protein, as did normal meninges. F...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.39.4.435
更新日期：1986-04-01 00:00:00
abstract：CLINICAL QUESTION:A 77-year-old man presented with haematuria. Cystoscopy revealed a papillary tumour in the trigone region of the bladder. A TURBT was performed. Review the high-quality, interactive digital Aperio slide at http://virtualacp.com/JCPCases/jclinpath-2016-204015 and consider your diagnosis. WHAT IS YOUR D...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2016-204015
更新日期：2017-07-01 00:00:00
abstract：:Immunoreactive plasminogen activators were studied in tissue sections using a peroxidase method and monospecific antibodies to tissue plasminogen activator produced by a melanoma. Tissue plasminogen activator reactivity was found in skin melanomas and in endothelial and smooth muscle cells of arteries and veins. Vesse...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.2.140
更新日期：1985-02-01 00:00:00
abstract：:The prevalence of lymphoid follicles in endoscopic biopsy specimens from normal antral mucosa (n = 220), mucosa with reflux gastritis (n = 104), and in cases with Campylobacter pylori-associated gastritis (n = 2544) was studied. In the latter group whether there were associations between degree and activity of gastrit...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.42.12.1269
更新日期：1989-12-01 00:00:00
abstract：:A case of acute myelomonocytic leukaemia (AMMOL) is reported in which skin infiltration with xanthomatous nodules was the presenting feature. The histological, including ultrastructural, appearances are described. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.35.11.1200
更新日期：1982-11-01 00:00:00
abstract：:The incidence of placenta accreta, defined as the abnormal adherence of the placenta to the uterine wall, has been increasing alarmingly in the developed as well as the developing world. There is considerable maternal morbidity and mortality related to the condition. The pathophysiology focuses on the balance between ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.2008.055202
更新日期：2008-12-01 00:00:00
abstract：:Escherichia coli O157:H7 was isolated from a fatal case of haemorrhagic colitis with haemolytic uraemic syndrome and neurological symptoms. This strain induced diarrhoea and neurological symptoms including incoordination, ataxia, and convulsions in piglets after oral inoculation. Similar neurological signs were seen i...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.41.10.1099
更新日期：1988-10-01 00:00:00
abstract：:A case of chronic neutrophilic leukaemia (CNL) is reported. The diagnosis was based on leucocytosis with mature neutrophils, a raised leucocyte alkaline phosphatase score, negative Philadelphia chromosome, and extensive infiltration of neutrophils in various differentiation stages into the bone marrow. When viewed by ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.4.367
更新日期：1994-04-01 00:00:00
abstract：:Strokes are one of the most common causes of mortality and long term severe disability. There is evidence that lipoprotein (a) (Lp(a)) is a predictor of many forms of vascular disease, including premature coronary artery disease. Several studies have also evaluated the association between Lp(a) and ischaemic (thrombot...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.53.7.487
更新日期：2000-07-01 00:00:00
abstract：AIMS:To investigate the histopathological features of the synovial lining of the knee following implantation of an artificial cruciate ligament. METHODS:Eighty two patients underwent anterior cruciate ligament reconstruction for chronic, symptomatic instability of the knee. The cruciate ligament was reconstructed with...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.48.6.556
更新日期：1995-06-01 00:00:00
abstract：:A new staining method was developed for the detection of inclusions of Chlamydia psittaci and Chlamydia trachomatis inclusions in cell cultures. Using a combination of methyl green and neutral red stains and washing at pH 5.0, inclusions were stained red while cell cytoplasm was pale pink and cell nuclei were pale gre...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.35.6.642
更新日期：1982-06-01 00:00:00
abstract：:Patients with bacterial infection may show altered membrane permeability of the primary azurophilic lysosomes of blood neutrophils. A new enzyme cytochemical technique, sensitive to increased membrane permeability caused by contact of neutrophils with acetone, saponin, low pH, Streptolysin O, bacteria, and nylon wool,...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.31.7.648
更新日期：1978-07-01 00:00:00
abstract：:A post-mortem examination, in the case of a 34-year-old man dying suddenly from head injuries sustained in a road accident, showed early cirrhosis of the liver and associated splenomegaly 17 years after an attack of infective hepatitis. The histology of the thymus showed abnormal changes in the medulla, consisting of ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.16.5.445
更新日期：1963-09-01 00:00:00
abstract：:A small epidemic of gastroenteritis in a children's hospital is described, and also the biochemical characteristics of the causative organism. Stress is laid on the fact that failure to recognize that epidemic strains of Escherichia coli may be late lactose fermentors can lead to errors or delay in diagnosis. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.15.5.482
更新日期：1962-09-01 00:00:00
abstract：AIM:To better understand the spectrum of primary lymphomas in the upper aerodigestive tract, a common site of extranodal lymphoma. MATERIALS AND METHODS:Lymphoma cases diagnosed at an institution in southern Taiwan from 1992 to 2007 were retrospectively studied with pathology and history review, immunohistochemistry, ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2010.081927
更新日期：2010-10-01 00:00:00
abstract：:Methods for detecting insulin binding or transporting antibodies are described, involving the use of radioactively labelled insulin (insulin (131)I). These antibodies are detected in a high proportion of patients receiving insulin, particularly those requiring large doses. The protein fractions concerned appear to be ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.16.2.120
更新日期：1963-03-01 00:00:00
abstract：AIM:To develop an expert system model for the diagnosis of fine needle aspiration cytology (FNAC) of the breast. METHODS:Knowledge and uncertainty were represented in the form of a Bayesian belief network which permitted the combination of diagnostic evidence in a cumulative manner and provided a final probability for...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.4.329
更新日期：1994-04-01 00:00:00
abstract：:A saccharogenic method is described for estimating amylase activity in human urine. Results accord with those reported elsewhere except that in this study the peak in the beta zone is a new finding. Comparison between normal and pathological urines suggests that the amylase activity of the beta peak is not of pancreat...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.18.5.664
更新日期：1965-09-01 00:00:00
abstract：:This review focuses on the pathological features of dysplasia in Barrett's oesophagus. Two categorisation schemes are used for grading dysplasia in the gastrointestinal tract, including Barrett's oesophagus. The inflammatory bowel disease dysplasia morphology study group system is the one most commonly used in the USA...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.2005.035337
更新日期：2006-10-01 00:00:00
abstract：:An enzyme linked immunoadsorbent assay (ELISA) was used to detect IgG, IgM, and IgA antibody in urine to a crude antigenic mixture prepared from six arbitrarily chosen strains of common coliform urinary pathogens. In a group of patients with symptoms of urinary tract infection 24 of 80 (30%) urine samples were positiv...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.40.7.787
更新日期：1987-07-01 00:00:00
abstract：:The possible use of sodium hypochlorite solution buffered to pH 7.6 and containing 100 ppm available chlorine (avCl) for disinfecting fibrescopes was investigated. A flexible fibrescope experimentally contaminated with Pseudomonas putida, Mycobacterium fortuitum, or Bacillus subtilis spores was effectively disinfected...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.35.3.296
更新日期：1982-03-01 00:00:00
abstract：:Mesothelial lesions pose considerable diagnostic challenges not only because benign tumours, reactive proliferations and malignant mesothelioma can mimic one another, but also because the morphological patterns displayed by malignant mesothelioma can simulate a variety of epithelial and non-epithelial malignancies. Im...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2005.029652
更新日期：2006-06-01 00:00:00
