Abstract:
:The study of cancer immunology has provided diagnostic and therapeutic instruments through serum autoantibody biomarkers and exogenous monoclonal antibodies. While some endogenous antibodies are found within or surrounding transformed tissue, the extent to which this exists has not been entirely characterized. We find that in transgenic and xenograft mouse models of cancer, endogenous gamma immunoglobulin (IgG) is present at higher concentration in malignantly transformed organs compared to non-transformed organs in the same mouse or organs of cognate wild-type mice. The enrichment of endogenous antibodies within the malignant tissue provides a potential means of identifying and tracking malignant cells in vivo as they mutate and diversify. Exploiting these antibodies for diagnostic and therapeutic purposes is possible through the use of agents that bind endogenous antibodies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rich BS,Honeyman JN,Darcy DG,Smith PT,Williams AR,Lim II,Johnson LK,Gönen M,Simon JS,LaQuaglia MP,Simon SMdoi
10.1038/srep05088subject
Has Abstractpub_date
2014-05-30 00:00:00pages
5088issn
2045-2322pii
srep05088journal_volume
4pub_type
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