Endogenous antibodies for tumor detection.

Abstract:

:The study of cancer immunology has provided diagnostic and therapeutic instruments through serum autoantibody biomarkers and exogenous monoclonal antibodies. While some endogenous antibodies are found within or surrounding transformed tissue, the extent to which this exists has not been entirely characterized. We find that in transgenic and xenograft mouse models of cancer, endogenous gamma immunoglobulin (IgG) is present at higher concentration in malignantly transformed organs compared to non-transformed organs in the same mouse or organs of cognate wild-type mice. The enrichment of endogenous antibodies within the malignant tissue provides a potential means of identifying and tracking malignant cells in vivo as they mutate and diversify. Exploiting these antibodies for diagnostic and therapeutic purposes is possible through the use of agents that bind endogenous antibodies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Rich BS,Honeyman JN,Darcy DG,Smith PT,Williams AR,Lim II,Johnson LK,Gönen M,Simon JS,LaQuaglia MP,Simon SM

doi

10.1038/srep05088

subject

Has Abstract

pub_date

2014-05-30 00:00:00

pages

5088

issn

2045-2322

pii

srep05088

journal_volume

4

pub_type

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