Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey.

Abstract:

:Data examining the association between vitamin D and diabetic peripheral neuropathy are limited. This study investigated the serum levels of vitamin D, vitamin D-binding protein (VDBP), and vitamin D receptor (VDR) in diabetics in the Yozgat region of Turkey, and assessed their relationships with diabetic peripheral neuropathy. 69 diabetic patients and 49 age- and sex-matched control subjects were enrolled in this clinical prospective study. All the diabetics underwent conventional sensory and motor nerve conduction studies, and diabetic peripheral neuropathy was confirmed or ruled out according to the electromyography findings and Douleur Neuropathique 4 questions. Serum vitamin D, VDBP and VDR levels were measured using commercial enzyme-linked immunosorbent assay kits. The serum vitamin D levels (p = 0.001) were significantly lower, while the VDR levels (p = 0.003) were higher, in diabetics than in controls. The serum VDBP levels were similar in both groups (p > 0.05). The serum vitamin D levels were significantly lower in diabetics with diabetic peripheral neuropathy than in those without (p = 0.032), whereas the serum VDBP and VDR levels were similar in these two groups (p > 0.05). The lower serum vitamin D levels in diabetics, especially in those with peripheral neuropathy, may suggest a neurotrophic effect of vitamin D.

journal_name

Acta Neurol Belg

journal_title

Acta neurologica Belgica

authors

Celikbilek A,Gocmen AY,Tanik N,Borekci E,Adam M,Celikbilek M,Suher M,Delibas N

doi

10.1007/s13760-014-0304-0

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

47-52

issue

1

eissn

0300-9009

issn

2240-2993

journal_volume

115

pub_type

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