Cyclosporine-A induced neurotoxicity after renal transplantation.

Abstract:

:Cyclosporine-A is a highly potent immunosuppressive agent for solid organ transplantation, but has many side effects including nephrotoxicity, hypertension, gum hyperplasia, hepatotoxicity, and neurotoxicity. Neurotoxicity is a less known toxic effect. The pathogenesis of this effect is unclear. However, it has been postulated that hypomagnesemia, hypocholesterolemia, corticosteroids, and/or neurotoxic substances can induce this syndrome. Also, it has been suggested that the endothelial damage caused by Cyclosporine-A may contribute to neuropeptide-mediated ischemia in the brain and lead to the development of neurological symptoms. In this report, we present a case with reversible neurologic deficits whose symptoms returned to normal after the cessation of cyclosporine-A.

journal_name

Acta Neurol Belg

journal_title

Acta neurologica Belgica

authors

Derici U,Arinsoy T,Sindel S,Tali T,Leventoglu A,Sert S

keywords:

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

124-7

issue

2

eissn

0300-9009

issn

2240-2993

journal_volume

101

pub_type

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