Abstract：
:The large choice of antiepileptic drugs (AEDs) in Belgium complicates the selection of the appropriate product for the individual patient. International guidelines on the treatment of epilepsy have been published, but are not tailored to the Belgian situation. This publication presents recommendations from a group of Belgian epilepsy experts for the practical management of epilepsy in general practice in Belgium. It includes recommendations for initial monotherapy and add-on treatment in adult patients (> or = 16 years) and initial monotherapy in paediatric patients (< 16 years). For these three situations a first choice AED is recommended. One or more alternative first choice AEDs are defined for patients in which certain patient- or AED-related factors preclude the use of the first choice product. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence of efficacy, common daily practice and the personal views and experiences of the authors. The paper reflects the situation in 2008. In addition to the treatment recommendations, other relevant points to consider in the treatment of epilepsy with AEDs are addressed, including comorbidity and age of the patient, the interaction potential, pharmacokinetic properties and safety profile of the AEDs, and generic substitution.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Boon P,Engelborghs S,Hauman H,Jansen A,Lagae L,Legros B,Ossemann M,Sadzot B,Urbain E,van Rijckevorsel Ksubject
Has Abstractpub_date
2008-12-01 00:00:00pages
118-30issue
4eissn
0300-9009issn
2240-2993journal_volume
108pub_type
杂志文章,实务指引abstract：:On the basis of eight case studies conducted since 1980 the authors define the concept of subdural hematoma showing a level on the CAT scan image. The concept throws some light on the etiopathogenesis of certain hematoma. ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1983-08-01 00:00:00
abstract：:The objective of the study was to investigate the associations between the degree of edema with the clinical and biochemical parameters such as serum lactate dehydrogenase (LDH), albumin (ALB) in posterior reversible encephalopathy syndrome (PRES) patients. Forty-nine patients with typical clinical symptoms and charac...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-012-0060-y
更新日期：2012-09-01 00:00:00
abstract：:Atomoxetine, a selective noradrenaline reuptake inhibitor, has been reported to enhance brain plasticity, but has not yet been used in stroke patients. We reported the feasibility and clinical benefits on motor functional recovery of the combination of repetitive transcranial magnetic stimulation (rTMS) and intensive ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-015-0503-3
更新日期：2016-03-01 00:00:00
abstract：:Multiple sclerosis (MS) often starts in the form of clinically isolated syndrome (CIS) and only some of the CIS patients progress to relapsing-remitting MS (RRMS). Biomarkers to predict conversion from CIS to MS are thus greatly needed for making correct treatment decisions. To identify a predictive cerebrospinal flui...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-018-0954-4
更新日期：2019-03-01 00:00:00
abstract：:Several genome-wide association studies have already explored the associations between rs498872 polymorphism and glioma, but the results of these studies were not consistent. Consequently, we conducted a meta-analysis of relevant studies to better analyze the effects of rs498872 polymorphism on individual susceptibili...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,meta分析
doi：10.1007/s13760-019-01081-y
更新日期：2019-06-01 00:00:00
abstract：:A 35-year-old female presented with three days' history of aching discomfort in her back, chest, and ankles. She had also noticed increasing weakness of her legs and a week before admission had shown flu-like symptoms. Chest X-ray showed bilateral hilar and right paratracheal lymphadenopathy. Bronchoscopic biopsies re...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：:The various neurological manifestations encountered in 40 zairians out of a total of 500 with homozygous (SS) Sickle cell disease were described. These included convulsions, vascular accidents, mental changes, increased intracranial pressure and meningism. The literature on the involvement of the nervous system in Sic...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:The authors present and illustrate most of the ultrastructural abnormalities encountered in skeletal muscle in cases of neuromuscular disease. The diagnostic significance of the changes are discussed but emphasis is laid on the nonspecific character of most of them. For diagnostic purposes, examination by light micros...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1981-03-01 00:00:00
abstract：:The aim of this study is to investigate the frequency of unilateral cranial autonomic symptoms during migraine attacks, and to compare the clinical characteristics of migraine patients with and without unilateral cranial autonomic symptoms. One hundred and eighty-six consecutive patients with episodic migraine attacks...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-012-0164-4
更新日期：2013-09-01 00:00:00
abstract：:This study investigates the correlation between brain magnetic resonance imaging findings and blink reflex abnormalities in patients with relapsing remitting multiple sclerosis. Twenty-six patients and 17 healthy subjects were included in this study. Blink reflex test (BRT) results were obtained using right and left s...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-012-0175-1
更新日期：2013-09-01 00:00:00
abstract：:Although cerebral palsy (CP), which affects the quality of life of many children and their families, is the most common cause of motor dysfunction in children, no comprehensive bibliometric study has holistically evaluated the publications on CP. This study aimed to analyze the scientific outputs published on CP in pe...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-020-01549-2
更新日期：2020-11-23 00:00:00
abstract：:Most of the brominated monoureide and bromide salt containing drugs are obtainable in Belgium without prescription. Apart from the regularly encountered suicidal attempts, these drugs can also, without the intention of the patient, cause bromism . We report two cases of patients recently admitted because of bromism af...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:We investigated the ophthalmologic manifestations and factors that influence outcomes in patients with myasthenia gravis (MG). We retrospectively analyzed the prevalence of neuro-ophthalmologic findings and clinical and outcome measures of 100 consecutive patients (53 males, 47 females), aged 55.7 ± 17.5 (range 15-85)...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-020-01556-3
更新日期：2021-01-04 00:00:00
abstract：:Electrophysiological tests (visual and somatosensory evoked potentials, flicker fusion test) and electrophoretic examination of cerebrospinal fluid were performed in 17 patients who previously suffered from one or more attacks of optic neuritis. The association of the tests revealed the demyelinating inflammatory path...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:Proposals about the regulations and medical criteria concerning epilepsy and driving, originally drawn up by the Commission on Epilepsy and Risk from the Belgian League against Epilepsy were discussed and amended by a panel of representatives of several scientific societies and of all Belgian universities in order to ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:Transient ischemic attack (TIA) is defined as a brief episode of neurological dysfunction caused by focal cerebral ischemia. TIA is a critical early warning signal of stroke. Patients with TIA may have long-term cognitive decline. The pathogenesis and pathological changes of TIA have not been fully elucidated. Animal ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：10.1007/s13760-020-01295-5
更新日期：2020-04-01 00:00:00
abstract：:In this study, serum triglyceride, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), vitamin B12 and folic acid levels were studied in children with epilepsy who had been receiving long-term valproate (V...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Previous studies of multiple sclerosis (MS) patients have reported an inverse correlation between disability, the number of relapses and vitamin D levels in mostly white patients. It is unclear if this relationship has the same behavior in individuals with Hispanic backgrounds. To determine the relationship between vi...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-017-0834-3
更新日期：2018-03-01 00:00:00
abstract：:Multiple sclerosis (MS) can cause alterations in autonomic cardiovascular functions. We aimed to investigate the correlation of disease activity and disability with heart rate variability (HRV) of cardiovascular autonomic dysfunction (CAD) demonstrated by 24-h Holter monitorization. Thirty-four patients with clinicall...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:Nine cases (seven men and two women, mean age 64.5 years) of classical lacunar syndromes due to intracerebral hemorrhage are reported. Three patients presented with pure motor hemiparesis (two putaminal hematomas with proportional weakness and one cortical hemorrhage with brachio-crural hemiparesis). Four patients pre...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:Serum and cerebrospinal fluid (CSF) of 13 patients have been examined to confirm and precise the diagnosis of herpes simplex virus encephalitis (HSVE). By amplifying the DNA with a nested polymerase chain reaction (PCR), we could demonstrate the herpetic origin of these cases of encephalitis. DNA of HSV type 1 or type...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：: ...
journal_title：Acta neurologica Belgica
pub_type： 信件
doi：10.1007/s13760-018-0979-8
更新日期：2019-03-01 00:00:00
abstract：:Non-traumatic dural arteriovenous fistula/malformation (dural AVF/AVM) presenting with pure subdural hematoma (SDH) is relatively rare. We report on a male patient who showed pure acute SDH and was diagnosed as having dural AVF on the convexity near the superior sagittal sinus (SSS), based on angiographic findings. A ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:Migraine headaches are common in children. Early diagnosis and appropriate interventions are mandatory to prevent decades of suffering and diminished quality of life. There is need for data regarding the efficacy and safety of prophylactic agents in children with migraine; therefore, we designed a randomized clinical ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s13760-012-0011-7
更新日期：2012-03-01 00:00:00
abstract：:Evidence suggests that symptoms of migraine are related to the involvement of the autonomic nervous system. Data on atrial conduction system are limited in migraineurs. We aimed to assess atrial electromechanical delay using tissue Doppler imaging (TDI) in patients with migraine. Forty-five migraine patients and age- ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-013-0273-8
更新日期：2014-12-01 00:00:00
abstract：:In recent years, different research lines have examined the epileptogenic process in order to understand the different stages in this process, and with the hope that early recognition and intervention could prevent chronic epilepsy in patients with epileptic seizures. In animals, acquired epilepsy is studied most comm...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：2003-06-01 00:00:00
abstract：:Dopa-responsive dystonia (DRD) and DRD plus are diseases of the dopamine pathway with sizeable genetic diversity and myriad presentations. DRD has onset in childhood or adolescence with focal dystonia, commonly affecting lower limb, diurnal fluctuations with evening worsening of symptoms and a demonstrable sleep benef...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：10.1007/s13760-020-01574-1
更新日期：2021-01-16 00:00:00
abstract：:Neurosarcoidosis is a diagnostic challenge, especially in the absence of systemic involvement, even when cerebral biopsies show noncaseating granulomas. We report a patient with a pineal germinoma associated with a extensive peri- and intra- tumoural granulomatous reaction, who was first diagnosed as possible neurosar...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：:The cerebral haemodynamic and metabolic changes due to cavernous angiomas in three patients and to arteriovenous malformations in four patients were compared by positron emission tomography, using the steady state technique with 15O. In the brains with a cavernous angioma no important changes in blood flow were observ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Guillain-Barré Syndrome (GBS) is best viewed as a clinical syndrome which can have at least two clinical substrates: the commonest is an acquired demyelinating polyradiculoneuropathy and the other is an acute motor axonal neuropathy. An acute acquired neuropathy can also sometimes cause the Miller Fisher syndrome of o...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
