Animal models of transient ischemic attack: a review.

Abstract:

:Transient ischemic attack (TIA) is defined as a brief episode of neurological dysfunction caused by focal cerebral ischemia. TIA is a critical early warning signal of stroke. Patients with TIA may have long-term cognitive decline. The pathogenesis and pathological changes of TIA have not been fully elucidated. Animal models can simulate the process of human diseases and are essential tools to investigate injury mechanisms and therapeutic approaches of TIA. Most TIA animal models are based on ischemic stroke models and the definition of TIA. Each model has unique strengths and weaknesses. The establishment of a successful and reliable TIA model should follow three criteria: (1) objective evidence of cerebral arteries occlusion and reperfusion, (2) no permanent neurological deficit, and (3) no acute cerebral infarction. However, experimental animal models are impossible to be completely consistent with human TIA, because TIA itself is a heterogeneous disease. In the present review, the selection of animals, methodological development, and evaluation of cerebral blood flow of animal models of TIA are comprehensively evaluated.

journal_name

Acta Neurol Belg

journal_title

Acta neurologica Belgica

authors

Wang J,Zhang P,Tang Z

doi

10.1007/s13760-020-01295-5

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

267-275

issue

2

eissn

0300-9009

issn

2240-2993

pii

10.1007/s13760-020-01295-5

journal_volume

120

pub_type

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