Abstract:
:Atomoxetine, a selective noradrenaline reuptake inhibitor, has been reported to enhance brain plasticity, but has not yet been used in stroke patients. We reported the feasibility and clinical benefits on motor functional recovery of the combination of repetitive transcranial magnetic stimulation (rTMS) and intensive occupational therapy (OT) in stroke patients. This pilot study was designed to evaluate the additive effects of oral atomoxetine to rTMS/OT in post-stroke hemiparetic patients. The study included three post-stroke patients with upper limb hemiparesis. Treatment with 40 mg/day atomoxetine commenced 2 weeks before admission. After confirming tolerance, the dose was increased to 120 mg/day. Low-frequency rTMS/OT was provided daily for 15 days during continued atomoxetine therapy. Motor function of the affected upper limb was evaluated with the Fugl-Meyer Assessment and Wolf Motor Function test. All patients completed the protocol and showed motor improvement up to 4 weeks after the treatment. No atomoxetine-related side effects were noted. Our protocol of triple therapy of atomoxetine, low-frequency rTMS, and OT is safe and feasible intervention for upper limb hemiparesis after stroke.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Kinoshita S,Kakuda W,Yamada N,Momosaki R,Okuma R,Watanabe S,Abo Mdoi
10.1007/s13760-015-0503-3subject
Has Abstractpub_date
2016-03-01 00:00:00pages
31-7issue
1eissn
0300-9009issn
2240-2993pii
10.1007/s13760-015-0503-3journal_volume
116pub_type
杂志文章abstract::In Parkinson's disease (PD), sleep disorders (SD) occur as a result of the neurochemical changes in sleep centres, neurodegenerative changes in dopaminergic neurons, and other factors. The most common SD include excessive daytime sleepiness, insomnia, restless legs syndrome and nocturia. The aim of the study was to co...
journal_title:Acta neurologica Belgica
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journal_title:Acta neurologica Belgica
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更新日期:1983-11-01 00:00:00
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doi:10.1007/s13760-014-0310-2
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pub_type: 杂志文章
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journal_title:Acta neurologica Belgica
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doi:
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章,meta分析
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doi:
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
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doi:10.1007/s13760-018-0905-0
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journal_title:Acta neurologica Belgica
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abstract:: ...
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:2009-09-01 00:00:00
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