Abstract:
:Multiple sclerosis (MS) is a neuro-immunological demyelinating disease. From the immunological aspects, it is well accepted that T cells play a pivotal role in the etiology of the disease. T helper (Th) 1 and Th17 cells are thought to be the main pathogenic T cells in the pathogenesis of MS and are known as effector T cells. As the self-reactive T lymphocytes can escape clonal deletion in the thymus and subsequently are released into the periphery, there is an urgent need for peripheral tolerance, which is executed by the specialized regulatory T (Treg) cells. Interestingly, CD8+ regulatory T (Treg) cells have also been identified among lymphocyte subtypes. The peripheral CD8+ Treg cells frequency in MS subjects in comparison with healthy controls is the objective of the current study using the systematic review and meta-analysis. A systematic literature search was carried out using specialized biomedical databases of Pubmed, Pubmed Central, Medline, Google Scholar, Embase and SCOPUS databases without the beginning date restriction until January 2018 in English language. The results were as follows: OR 15.548 (95% confidence interval 1.954-123.742) using the random-effects model. The P value for test of significance of the total OR was examined by the z test and calculated as 0.010 (clearly considered as statistically significant). Based on our findings, the number of CD8+ Treg cells in the blood of MS subjects is significantly different as compared to healthy controls.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Seidkhani-Nahal A,Noori-Zadeh A,Bakhtiyari S,Khosravi Adoi
10.1007/s13760-018-1028-3subject
Has Abstractpub_date
2019-03-01 00:00:00pages
61-68issue
1eissn
0300-9009issn
2240-2993pii
10.1007/s13760-018-1028-3journal_volume
119pub_type
杂志文章,meta分析abstract::In contrast to the classic, slowly progressive polyneuropathy in alcoholic patients, acute forms, clinically mimicking Guillain-Barré syndrome, are rare. We present a patient who developed motor weakness and sensory loss in all four limbs within four days. Laboratory data were consistent with long-term alcohol abuse a...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::CADASIL is an autosomal dominant inherited arteriopathy caused by a point mutation in the Notch3 gene. Classically, it is characterised by recurrent ischemic strokes, often resulting in mental decline. Intracerebral haemorrhages in CADASIL have rarely been reported. We describe a young male with a genetically proven C...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2006-12-01 00:00:00
abstract::Self-reporting scales are commonly utilized in determining appropriate treatment strategies and follow-up in hand-related disorders. Responsiveness is described as the ability of a scale to detect clinically significant changes. We aimed to evaluate responsiveness of Michigan Hand Outcomes Questionnaire (MHQ), Duruöz ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-020-01443-x
更新日期:2020-07-15 00:00:00
abstract::Febrile seizures (FS) are recognized as an antecedent to the development of temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), but it is unclear whether prolonged FS are a direct cause of TLE-HS. Here, we used a rat model of infantile FS to study the effects of inflammatory cytokines on seizure susceptibility...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-013-0246-y
更新日期:2014-09-01 00:00:00
abstract::Neuromyelitis optica spectrum disorder (NMOSD) has unknown risk factors. The aim of this study was to identify the environmental risk factors for NMOSD. A case-control study was conducted in Tehran from 2015 to 2016 among 100 patients with NMOSD. Sex-matched healthy controls (n = 400) were selected through random digi...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-018-0900-5
更新日期:2018-06-01 00:00:00
abstract:: ...
journal_title:Acta neurologica Belgica
pub_type: 信件
doi:10.1007/s13760-017-0846-z
更新日期:2019-03-01 00:00:00
abstract::The ictal bradycardia syndrome is an uncommon diagnosis in which bradycardia is accompanied by simultaneous epileptic discharges in the EEG. We describe a patient who was referred to the emergency ward because of syncope. Ictal semeiology and EEG-EG findings are discussed and compared with those published in the liter...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract::Nine cases (seven men and two women, mean age 64.5 years) of classical lacunar syndromes due to intracerebral hemorrhage are reported. Three patients presented with pure motor hemiparesis (two putaminal hematomas with proportional weakness and one cortical hemorrhage with brachio-crural hemiparesis). Four patients pre...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::Three patients with hypereosinophilia showed different forms of peripheral neuropathy: severe polyneuropathy of prevalently sensory type (case 1), mild sensory neuropathy (case 2), acute mononeuropathy of the median nerve with subclinical polyneuropathy (case 3). Hypereosinophilia was probably idiopathic, however the ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Meningiomas are common tumors of the central nervous system. Although most are benign tumors, approximately 10% show a histologic progression to a higher malignancy grade similar to atypical (GII) and anaplastic (GIII) meningiomas. Monosomy 22q12 is the most frequent genetic alteration detected in these tumo...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::We performed a retrospective study of 62 patients with syringomyelia. Most noteworthy among the clinical features in our patient population are the following: segmental sensory disturbances are usually less restrictive than the classical thermoanalgesia, pain is a presenting symptom in almost 50% of cases, and skeleta...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::In recent years, different research lines have examined the epileptogenic process in order to understand the different stages in this process, and with the hope that early recognition and intervention could prevent chronic epilepsy in patients with epileptic seizures. In animals, acquired epilepsy is studied most comm...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:2003-06-01 00:00:00
abstract::A study of neurotransmitter release has been performed on human brain biopsies obtained during the course of a therapeutic neurosurgical procedure. The electrically evoked-release of 3H-dopamine and 3H-acetylcholine was studied on slices from the thalamus of two parkinsonian and two non-parkinsonian subjects. Electric...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Early onset dementia (EOD) is a major diagnostic challenge as it often presents with atypical features and may be attributed to treatable diseases. Primary degenerative dementias (Alzheimer's disease-AD, frontotemporal lobar degeneration-FTLD, Lewy body dementia-LBD), although traditionally considered to affect older ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-014-0310-2
更新日期:2015-03-01 00:00:00
abstract::Friedreich's ataxia (FRDA), an autosomal recessive disorder, is characterized by spinocerebellar degeneration and cardiomyopathy. Here we explore some of the putative mechanisms underlying the cardiomyopathy in FRDA that have been elucidated using different experimental models. FRDA is characterized by a deficiency in...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To study the impact of cognitive impairment and severity of dementia on the quality of life (QoL) of patients and their caregivers. DESIGN:Descriptive cross-sectional study within the NAtional Dementia Economic Study. SETTING:231 general practices and 15 specialist clinics in Belgium. SUBJECTS:605 patients...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::A correlation is made between the index of circulatory resistance given by ultrasonic flow-measurement and rheography. Patients with normal and increased blood pressure were studied. The characteristics of the transient and of the permanent ischaemic attacks are defined. ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Blood circulating endothelial cells and circulating hematopoietic progenitor cells (CPCs) are two cell populations that are thought to play important role in angiogenesis. In the present study, we investigated the role of CPCs in patients with brain tumors. We prospectively studied 19 brain tumor patients. Ten healthy...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-012-0097-y
更新日期:2013-03-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic disease, the etiology of which has yet to be clarified, which causes activation of proinflammatory pathways that bring about joint and systemic inflammation. Although peripheral nervous system anomalies are observed widely in RA, very few case reports on changes in the central ne...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-017-0879-3
更新日期:2020-02-01 00:00:00
abstract::As dystonia may represent a severe disease with possible fatal outcome or physical or social incapacity, and considering the limited efficacy of drug treatments (excepted doparesponsive dystonia), efforts have been made since the 1950s to propose alternative treatment. In this paper, an overview of the works done by n...
journal_title:Acta neurologica Belgica
pub_type: 传,历史文章,杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::The aim of this study was to investigate personality, by means of the Rorschach Psychodiagnostic test, in a consecutive series of fourteen patients with Parkinson's disease (PD) submitted to bilateral deep brain stimulation of the subthalamic nucleus (DBS STN). Patients were evaluated pre-operatively and 1 year after ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::A 35-year-old female presented with three days' history of aching discomfort in her back, chest, and ankles. She had also noticed increasing weakness of her legs and a week before admission had shown flu-like symptoms. Chest X-ray showed bilateral hilar and right paratracheal lymphadenopathy. Bronchoscopic biopsies re...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:A retrospective evaluation of the ictal temporal tracer uptake and the perfusion pattern in other neo- and subcortical structures was performed to define typical extratemporal changes of rCBF that might further aid the differentiation of temporal and extratemporal seizures. METHOD:Ictal and interictal rCBF bra...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::Smoking is associated with increased multiple sclerosis (MS) risk. In addition, some studies have reported that smoking is associated with anxiety and depression. However, the associations between smoking, walking, and fatigue are needed to be investigated. The objective was to investigate the associations between cig...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-020-01341-2
更新日期:2020-03-28 00:00:00
abstract::To evaluate the relationship between disease duration, disability, disease pattern, age and sex with fatigue in MS patients. One hundred and seventy-three clinically definite MS patients and 87 age-matched healthy controls enrolled in this cross sectional study. Demographic data (sex, age), duration of the disease and...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-013-0198-2
更新日期:2013-12-01 00:00:00
abstract::Recovery of stroke-related aphasia can be affected by language therapy in the early and chronic stage. Objectively monitoring therapy-induced neuroplasticity is possible by several measurement techniques including electro- and magneto-encephalography. The obtained event-related potentials (ERPs) and fields (ERFs) prov...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-020-01378-3
更新日期:2020-08-01 00:00:00
abstract:UNLABELLED:Although there only have been a limited number of double-blind, placebo controlled trials, antipsychotics are considered to be effective drugs for the treatment of tics in Gilles de la Tourette syndrome (GTS). Evidence concerning the efficacy of olanzapine and other atypical antipsychotics in the treatment o...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:After Sub-Thalamic Nucleus Deep Brain Stimulation (STN-DBS), an effective treatment for Parkinson disease patients, weight gain has been observed. As this method of treatment is only in use since two years in Iran, no information regarding its side effects (including weight gain) existed thus far. OBJECTIVE...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2010-12-01 00:00:00
abstract::Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable cause of stroke and vascular dementia in adults. We present a family from Serbia presenting with stroke and depression in the lack of vascular risk factors, with brain MRI indicating CADASI...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-012-0174-2
更新日期:2013-09-01 00:00:00
abstract::A 60-year-old man was admitted with slowly progressive dizziness. Cranial nerve evaluation found no abnormalities. Magnetic resonance imaging revealed a well-circumscribed mass with homogeneous enhancement located in the fourth ventricle. The patient underwent surgery for the removal of the tumor via the bilateral sub...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-012-0040-2
更新日期:2012-03-01 00:00:00