Abstract：
:Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) is involved in the pathogenesis of central nervous system (CNS) demyelination disorders. We aimed to explore the spectrum of MOG-Ab-associated diseases in eastern India. A single-center, prospective observational study was done over a period of 2 years in a tertiary care hospital of eastern India. Patients with CNS demyelination disorders who tested positive for MOG-Ab using live cell-based assay were included in the study; while, those with age less than 1 year, documented preexisting CNS structural lesions, developmental delays or diagnosed multiple sclerosis were excluded. Demographic profile, clinical spectrum, disease course, radiological features as well as response to treatment were analyzed among included patients. Twenty MOG-Ab-positive patients were included (M:F 1:1.85). The median age of symptom onset was 10.5 years. The median follow-up of patients was 13 months. Acute disseminated encephalomyelitis (ADEM) was the commonest presentation at first attack (55%), followed by optic neuritis (ON) (45%). Patients with ADEM had a significantly lower age at first attack (p = 0.025). Monophasic and relapsing disease courses were seen in 45% and 55% patients, respectively. While all patients with only ADEM had a monophasic course, 77.8% with ON had a relapsing course. Among patients who presented with isolated transverse myelitis, 75% had a monophasic course and all had disease confined to the spinal cord. Good response to corticosteroids was seen in majority of participants. Second-line drugs were needed in 55% patients, rituximab being the commonest second-line agent used. 35% patients had significant disability (EDSS > 4) at last follow-up. MOG-Ab-associated diseases have diverse clinical phenotypes characterized by age-dependent pattern-specific courses.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Chaudhuri J,Biswas T,Ganguly G,Datta S,Pandit A,Biswas Adoi
10.1007/s13760-020-01356-9subject
Has Abstractpub_date
2020-04-20 00:00:00eissn
0300-9009issn
2240-2993pii
10.1007/s13760-020-01356-9pub_type
杂志文章abstract：:A language test protocol for aphasia in French-speaking patients was drawn up recently by workers in Toulouse and Montreal. The protocol has been applied to sixty hospitalized sciatica patients of the same age range and socio-cultural level as the average population of aphasics in our department. Only one of the norma...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
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abstract：:Cyclosporine-A is a highly potent immunosuppressive agent for solid organ transplantation, but has many side effects including nephrotoxicity, hypertension, gum hyperplasia, hepatotoxicity, and neurotoxicity. Neurotoxicity is a less known toxic effect. The pathogenesis of this effect is unclear. However, it has been p...
journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
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doi：
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journal_title：Acta neurologica Belgica
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doi：
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journal_title：Acta neurologica Belgica
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pub_type： 杂志文章
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journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-018-0954-4
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
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abstract：: ...
journal_title：Acta neurologica Belgica
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doi：
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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