Abstract:
:Small fiber neuropathy (SFN), due to loss of A-delta and unmyelinated C fibers, is a cause of neuropathic pain. Although the patients with vitamin B12 deficiency are included in SFN studies in the literature, there is no histopathological study investigating the small fiber loss solely in patients with vitamin B12 deficiency. In this pilot study, we aim to demonstrate the intraepidermal nerve fiber density (IENFD) in skin punch biopsy of patients with vitamin B12 deficiency. Ten patients with vitamin B12 deficiency suffering from neuropathic pain and as control group ten patients with vitamin B12 deficiency without neuropathic pain were included. Neurological examination, electrophysiological evaluation, and DN4 questionnaire were performed. Subsequently, skin punch biopsy 10 cm above the lateral malleolus was done. The biopsy samples were stained with PGP9.5 antibody, and IENFD was determined. IENFD was low in two groups compared to their age normative values. The median of IENFD was 3.345 (1.12-5.32) in patients with neuropathic pain and 6. 20 (4.6-9.8) in controls (p < 0.001). Our pilot study showed that vitamin B12 deficiency causes symptomatic as well as asymptomatic small fiber loss like diabetes mellitus.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Güneş HN,Bekircan-Kurt CE,Tan E,Erdem-Özdamar Sdoi
10.1007/s13760-017-0847-ysubject
Has Abstractpub_date
2018-09-01 00:00:00pages
405-410issue
3eissn
0300-9009issn
2240-2993pii
10.1007/s13760-017-0847-yjournal_volume
118pub_type
杂志文章abstract::Primary breast lymphoma (PBL) is an uncommon extranodal type of lymphoma, exhibiting more aggressive behavior and poorer prognosis. Patients with PBL have a higher incidence to relapse in central nervous system (CNS), which is always leading to a dismal outcome even treating with high intensity chemotherapy plus radio...
journal_title:Acta neurologica Belgica
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doi:10.1007/s13760-012-0052-y
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abstract::Epilepsy and psychiatric diseases are frequent comorbidities. Psychoses in patients with epilepsy have special physiopathology and several clinical presentations and prognoses. Their treatments are also specific, according to the specific diagnosis. This paper represents the summary of a consensus meeting held in Nove...
journal_title:Acta neurologica Belgica
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abstract:UNLABELLED:Although there only have been a limited number of double-blind, placebo controlled trials, antipsychotics are considered to be effective drugs for the treatment of tics in Gilles de la Tourette syndrome (GTS). Evidence concerning the efficacy of olanzapine and other atypical antipsychotics in the treatment o...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2005-12-01 00:00:00
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abstract::Chorea paralytica (or chorea mollis) is a very rare variant of Sydenham's chorea, characterized by a profound hypotonia, resulting in severe disability. Given the rarity of this condition, data on its prognosis are lacking. Most reports suggest that the delay from onset to recover total autonomy is long, usually sever...
journal_title:Acta neurologica Belgica
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doi:10.1007/s13760-013-0214-6
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abstract:BACKGROUND:The present study was designed to describe the characteristics, risk factors and prognosis of patients diagnosed with CVT in our center. METHOD:The present retrospective cross-sectional study was conducted on patients diagnosed with cerebral vein or sinus thrombosis based on the patients' clinical presentat...
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journal_title:Acta neurologica Belgica
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更新日期:2004-03-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2009-12-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-017-0834-3
更新日期:2018-03-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章,随机对照试验
doi:10.1007/s13760-016-0689-z
更新日期:2017-03-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
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abstract::To determine the clinical profile and etiology of epilepsy in elderly patients in rural population of India which is in a phase of demographic transition with steadily growing geriatric population. A cross-sectional, prospective, hospital-based clinicoepidemiological study was performed from October 2014 to November 2...
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:1999-12-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
abstract::A case of bilateral agraphia produced by a left parietal glioma is described in a 49 year-old right-handed woman. Hypothesis of a pure agraphia, etiology and non-frontal localisation of tumor are discussed. This agraphia is associated to a right astereognosia; neither functional nor behavioral relationships are found ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2011-06-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
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更新日期:1976-01-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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