Abstract:
:Over the last decade, many new drugs have been added to the therapeutic armamentarium for epilepsy. These drugs differ considerably in their mechanisms of action and, consequently, in their spectrum of efficacy against various seizure types. Oxcarbazepine, gabapentin, tiagabine and vigabatrin are especially useful in the management of partial seizures (with or without secondary generalization) and, probably, also primarily generalized tonic-clonic seizures, with vigabatrin being of particular value also in the treatment of infantile spasms. The spectrum of efficacy of lamotrigine and topiramate is broader than that of the other drugs and includes, in addition to partial and tonic-clonic seizures, also drop attacks associated with the Lennox-Gastaut syndrome. Lamotrigine is also effective against absence seizures, while the activity of topiramate as a potential anti-absence drug has not been adequately explored. Oxcarbazepine, vigabatrin and tiagabine may aggravate myoclonic and absence seizures and, likewise, gabapentin may aggravate myoclonic seizures. Therefore, the latter drugs should not be used (or used with great caution) in patients with syndromes associated with these seizure types. Apart from differences in spectrum of efficacy, side effect profiles also differ considerably from one drug to another, with the risk of serious adverse effects limiting considerably the use of felbamate and vigabatrin. When added to preexisting therapy in patients with refractory epilepsies, the new drugs improve seizure frequency in 15% to 40% of cases, but only rarely freedom from seizures is achieved. In newly diagnosed patients, the efficacy of the new drugs is similar to that of older agents, but further studies are required to confirm the claim that the tolerability of some of these agents is superior to that of established drugs such as carbamazepine or valproate. The new antiepileptic drugs represent a useful addition to the therapeutic armamentarium, but because of limited clinical experience and cost considerations their firstline use cannot be recommended in most situations.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Perucca Ekeywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
231-8issue
4eissn
0300-9009issn
2240-2993journal_volume
99pub_type
杂志文章,评审abstract::We report an unusual case of probable progressive multifocal leukoencephalopathy (PML), who initially presented with a right-sided movement disorder, including upper limb dystonia, tremor, and dyspraxia, reminiscent of corticobasal degeneration. In the further course, the patient developed disorientation, confusion, a...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:The present study was designed to describe the characteristics, risk factors and prognosis of patients diagnosed with CVT in our center. METHOD:The present retrospective cross-sectional study was conducted on patients diagnosed with cerebral vein or sinus thrombosis based on the patients' clinical presentat...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract::Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable cause of stroke and vascular dementia in adults. We present a family from Serbia presenting with stroke and depression in the lack of vascular risk factors, with brain MRI indicating CADASI...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-012-0174-2
更新日期:2013-09-01 00:00:00
abstract::Many studies have reported that repetitive transcranial magnetic stimulation (rTMS) is beneficial for post-stroke patients with upper limb hemiparesis. It was reported that application of rTMS during sleep could possibly strengthen neural plasticity. The purpose of this study was to investigate the relationship betwee...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-018-0957-1
更新日期:2019-06-01 00:00:00
abstract::Stroke is still a major cause of morbidity and mortality throughout the world, although better stratification and treatment modalities are being developed. As compared to ischemic stroke, intracerebral hemorrhage (ICH) possesses many unknown data and lacks guidelines for better prophylaxis. In this study, we aimed to ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-013-0222-6
更新日期:2013-12-01 00:00:00
abstract::Neuropathology plays a crucial role in the phenotypic individualization of hereditary disorders affecting the central and peripheral nervous system even if molecular genetics represents the most essential step in describing the genotypes. The neuropathological description of phenotypes and genotypes can be used for re...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:2002-03-01 00:00:00
abstract::We performed a systematic neurophysiological evaluation of newborns-infants newly diagnosed with congenital hypothyroidism and started on replacement therapy, in order to document the maturation of visual, auditory and somesthetic pathways and to evaluate the influence of treatment. Twenty-one patients (9 boys, 12 gir...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-014-0331-x
更新日期:2015-06-01 00:00:00
abstract::The authors report the case of a 17 year-old female patient who presented acute ascending polyneuritis of the Landry-Guillain-Barré type extending to all cranial nerve pairs during the abatement of hepatitis of unspecified etiology. The patient remained in a state of coma vigil for five days prior to gradual but full ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1980-07-01 00:00:00
abstract::Evidence suggests that symptoms of migraine are related to the involvement of the autonomic nervous system. Data on atrial conduction system are limited in migraineurs. We aimed to assess atrial electromechanical delay using tissue Doppler imaging (TDI) in patients with migraine. Forty-five migraine patients and age- ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-013-0273-8
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:After Sub-Thalamic Nucleus Deep Brain Stimulation (STN-DBS), an effective treatment for Parkinson disease patients, weight gain has been observed. As this method of treatment is only in use since two years in Iran, no information regarding its side effects (including weight gain) existed thus far. OBJECTIVE...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2010-12-01 00:00:00
abstract::The primary source of malignant intracerebral nerve sheath tumors is still unclear We report the imaging and MR spectroscopic findings in a 39-year-old man with a very rare brain stem tumor MR examination revealed the presence of intraaxial brain stem tumor with a partial exophytic growth. On pathological examination,...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract::Transient ischemic attack (TIA) is defined as a brief episode of neurological dysfunction caused by focal cerebral ischemia. TIA is a critical early warning signal of stroke. Patients with TIA may have long-term cognitive decline. The pathogenesis and pathological changes of TIA have not been fully elucidated. Animal ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-020-01295-5
更新日期:2020-04-01 00:00:00
abstract:: ...
journal_title:Acta neurologica Belgica
pub_type: 信件
doi:10.1007/s13760-018-0897-9
更新日期:2018-12-01 00:00:00
abstract::Although cerebral palsy (CP), which affects the quality of life of many children and their families, is the most common cause of motor dysfunction in children, no comprehensive bibliometric study has holistically evaluated the publications on CP. This study aimed to analyze the scientific outputs published on CP in pe...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-020-01549-2
更新日期:2020-11-23 00:00:00
abstract::Non-traumatic dural arteriovenous fistula/malformation (dural AVF/AVM) presenting with pure subdural hematoma (SDH) is relatively rare. We report on a male patient who showed pure acute SDH and was diagnosed as having dural AVF on the convexity near the superior sagittal sinus (SSS), based on angiographic findings. A ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2010-06-01 00:00:00
abstract::Data examining the association between vitamin D and diabetic peripheral neuropathy are limited. This study investigated the serum levels of vitamin D, vitamin D-binding protein (VDBP), and vitamin D receptor (VDR) in diabetics in the Yozgat region of Turkey, and assessed their relationships with diabetic peripheral n...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-014-0304-0
更新日期:2015-03-01 00:00:00
abstract::There have been recent reports of antibody-mediated status epilepticus. The objective of our study was to investigate the prevalence of neuronal autoantibodies in patients with status epilepticus (SE) with unresolved etiology. The presence of neuronal autoantibodies was investigated prospectively in adult patients wit...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-017-0796-5
更新日期:2017-12-01 00:00:00
abstract::The cerebral haemodynamic and metabolic changes due to cavernous angiomas in three patients and to arteriovenous malformations in four patients were compared by positron emission tomography, using the steady state technique with 15O. In the brains with a cavernous angioma no important changes in blood flow were observ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic disease, the etiology of which has yet to be clarified, which causes activation of proinflammatory pathways that bring about joint and systemic inflammation. Although peripheral nervous system anomalies are observed widely in RA, very few case reports on changes in the central ne...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-017-0879-3
更新日期:2020-02-01 00:00:00
abstract::Neuromyelitis optica spectrum disorder (NMOSD) has unknown risk factors. The aim of this study was to identify the environmental risk factors for NMOSD. A case-control study was conducted in Tehran from 2015 to 2016 among 100 patients with NMOSD. Sex-matched healthy controls (n = 400) were selected through random digi...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-018-0900-5
更新日期:2018-06-01 00:00:00
abstract::The authors report a case of ataxic hemiparesis (dysarthria-clumsy hand syndrome plus crural hemiparesis with homolateral ataxia), secondary to a single cerebellar lacuna (CT scan), in a left rostral para-vermian position in the vicinity of the peduncle and secondary to arterial hypertension. They discuss the nosologi...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:1989-03-01 00:00:00
abstract::The most common causes of chronic cough in nonsmokers are postnasal drip syndrome, asthma, and gastroesophageal reflux disease. Drugs are also important in the etiology of resistant cough. Most common drugs inducing cough are the ACE inhibitors. Many drugs other than ACE inhibitors can also cause dry cough and one amo...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-012-0016-2
更新日期:2012-06-01 00:00:00
abstract::Dopa-responsive dystonia (DRD) and DRD plus are diseases of the dopamine pathway with sizeable genetic diversity and myriad presentations. DRD has onset in childhood or adolescence with focal dystonia, commonly affecting lower limb, diurnal fluctuations with evening worsening of symptoms and a demonstrable sleep benef...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-020-01574-1
更新日期:2021-01-16 00:00:00
abstract:PURPOSE:total removal of spinal hemangioblastomas with satisfactory clinical outcomes remains a challenge. We aimed to evaluate the surgical outcomes of our spinal hemangioblastomas patients, summarize our experiences with this condition and review-related literature. METHODS:records of 18 spinal hemangioblastoma pati...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-020-01420-4
更新日期:2020-07-07 00:00:00
abstract::Cyclosporine-A is a highly potent immunosuppressive agent for solid organ transplantation, but has many side effects including nephrotoxicity, hypertension, gum hyperplasia, hepatotoxicity, and neurotoxicity. Neurotoxicity is a less known toxic effect. The pathogenesis of this effect is unclear. However, it has been p...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::Celiac disease (CD) and non celiac gluten sensitivity (NCGS) can be responsible for neurological complications such as ataxia and peripheral neuropathies but also cognitive impairment. This cognitive involvement is variable in its expression, its duration and its prognosis ranging from transient and reversible subtle ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-017-0870-z
更新日期:2018-03-01 00:00:00
abstract::On the basis of 90 cerebral AVMs, the authors study clinical signs which show the AVM, before a dramatic bleeding. Such clinical signs are: benign subarachnoid hemorrhage or intracranial hypertension and, only for lobar AVMs, migraine, epileptic seizures, progressive neurological deficit. In such cases a misdiagnosis ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract::In recent years, different research lines have examined the epileptogenic process in order to understand the different stages in this process, and with the hope that early recognition and intervention could prevent chronic epilepsy in patients with epileptic seizures. In animals, acquired epilepsy is studied most comm...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:2003-06-01 00:00:00
abstract::CADASIL is an autosomal dominant inherited arteriopathy caused by a point mutation in the Notch3 gene. Classically, it is characterised by recurrent ischemic strokes, often resulting in mental decline. Intracerebral haemorrhages in CADASIL have rarely been reported. We describe a young male with a genetically proven C...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2006-12-01 00:00:00
abstract::After a lapse of not less than two years the authors study the functional and clinical evolution of 62 patients presenting myelopathy in cervical arthrosis treated by surgery. A scoring system for evaluating the functional deficit of the patients is used for quantitative assessment of the disorders. Surgery brought a ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00