Abstract:
:Amyotrophic Lateral Sclerosis and CHARGE syndrome are complex neurological disorders, which never occurred together in the same family and, to date, no putative correlation between them has been described on PubMed Central. Due to our aim was to evaluate the presence of different genetic variants involved in these pathologies, we reported a clinical and genetic description of two sisters affected by these two different disorders. In the CHARGE patient, molecular analysis of the CHD7 gene revealed the c.8016G >A de novo variant in exon 37. The ALS patient had been screened negative for mutations in SOD1, TARDBP, FUS/TLS, C9orf72 and KIF5A genes. Anyway, targeted next generation sequencing analysis identified known and unknown genetic variations in 39 ALS-related genes: a total of 380 variants were reported, of which 194 in the ALS patient and 186 in the CHARGE patient. To date, although the results suggest that the occurrence of the two syndromes in the same family is co-incidental rather than based on a causative genetic variant, we could hypothesize that other factors might act as modulators in the pathogenesis of these different phenotypes.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Ungaro C,Citrigno L,Trojsi F,Sprovieri T,Gentile G,Muglia M,Monsurrò MR,Tedeschi G,Cavallaro S,Conforti FLdoi
10.1007/s13760-018-1029-2subject
Has Abstractpub_date
2018-12-01 00:00:00pages
629-635issue
4eissn
0300-9009issn
2240-2993pii
10.1007/s13760-018-1029-2journal_volume
118pub_type
杂志文章abstract::Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) is involved in the pathogenesis of central nervous system (CNS) demyelination disorders. We aimed to explore the spectrum of MOG-Ab-associated diseases in eastern India. A single-center, prospective observational study was done over a period of 2 years in a tertiar...
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journal_title:Acta neurologica Belgica
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journal_title:Acta neurologica Belgica
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journal_title:Acta neurologica Belgica
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abstract:: ...
journal_title:Acta neurologica Belgica
pub_type: 信件
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journal_title:Acta neurologica Belgica
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更新日期:1985-11-01 00:00:00
abstract::On the basis of 90 cerebral AVMs, the authors study clinical signs which show the AVM, before a dramatic bleeding. Such clinical signs are: benign subarachnoid hemorrhage or intracranial hypertension and, only for lobar AVMs, migraine, epileptic seizures, progressive neurological deficit. In such cases a misdiagnosis ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1979-09-01 00:00:00
abstract::There have been recent reports of antibody-mediated status epilepticus. The objective of our study was to investigate the prevalence of neuronal autoantibodies in patients with status epilepticus (SE) with unresolved etiology. The presence of neuronal autoantibodies was investigated prospectively in adult patients wit...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-017-0796-5
更新日期:2017-12-01 00:00:00
abstract::Catatonia was first described by Kahlbaum in 1874. Ever since, the concept of catatonia has been the focus of debate, a major point of discussion being its nosological status. The question rises whether it is to be considered a syndrome with a wide variety of causes and clinical signs or a distinct clinical entity. Si...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract::Clinical records and EEGs of 114 consecutive patients with clinical diagnosis of Alzheimer's disease have been reviewed. The EEGs of 15 patients (13%) contained triphasic waves. Triphasic waves were always atypical as they occurred singularly or in short bursts, and/or they had occipital predominance, and/or they were...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::We wanted to explore possible differences in disease presentation, frequency, and age of onset of dementia with Lewy bodies (DLB) between first-generation immigrants (FGI) and patients born in Belgium (PBIB). We conducted a retrospective study on all patients of our Memory Clinic between June 1, 2010 and January 31, 2...
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doi:10.1007/s13760-020-01492-2
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-012-0060-y
更新日期:2012-09-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1974-11-01 00:00:00
abstract::Cluster headache (CH) is among the most painful headache disorders. There is still no unifying pathophysiological hypothesis to explain the trigeminal distribution, the circadian periodicity and the autonomic symptoms of the syndrome. We report the case of a patient with worsening of CH following administration of pra...
journal_title:Acta neurologica Belgica
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更新日期:2010-09-01 00:00:00
abstract::Many studies have reported that repetitive transcranial magnetic stimulation (rTMS) is beneficial for post-stroke patients with upper limb hemiparesis. It was reported that application of rTMS during sleep could possibly strengthen neural plasticity. The purpose of this study was to investigate the relationship betwee...
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journal_title:Acta neurologica Belgica
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更新日期:2006-03-01 00:00:00
abstract::The purpose of the study was to evaluate the relationship between sympathetic skin responses (SSR), electrodiagnostic reflex activities (F wave, H reflex), and functional capacity in post-stroke patients. The study comprised 40 hemiplegia patients (mean age 57.8 ± 10.9 years) and 40 healthy volunteers (mean age 557 ± ...
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abstract::Appropriate treatment of neonatal seizures with an effective therapy is important in reducing long-term neurologic disabilities. Sixty-seven neonates, who received intravenous (IV) levetiracetam (LEV) as first-line therapy for treating seizures between 2013 and 2017 were evaluated retrospectively to investigate the ef...
journal_title:Acta neurologica Belgica
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abstract::Amyotrophic lateral sclerosis (ALS) is associated with frontotemporal lobar degeneration (FTLD) in 15% of the cases. A neuropathological continuity between ALS and FTLD-TDP is suspected. The present post-mortem 7.0-tesla magnetic resonance imaging (MRI) study compares the topographic distribution of iron (Fe) depositi...
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abstract::Neurosarcoidosis is a diagnostic challenge, especially in the absence of systemic involvement, even when cerebral biopsies show noncaseating granulomas. We report a patient with a pineal germinoma associated with a extensive peri- and intra- tumoural granulomatous reaction, who was first diagnosed as possible neurosar...
journal_title:Acta neurologica Belgica
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更新日期:2009-06-01 00:00:00
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