Abstract：
:Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic process that typically occurs in the setting of immune dysregulation. In contrast to the characteristic pattern involving parieto-occipital and posterior frontal regions, predominant involvement of the infratentorial brain occurs in a minority of PRES patients. We examined six patients with infratentorial predominant posterior reversible encephalopathy syndrome (IPPRES) relative to those with typical PRES in terms of clinical factors of toxicity and outcomes. We review the current understanding of PRES pathophysiology. An institutional database of PRES patients was created through an IRB-approved search of the electronic record from 2007 to 2012. MR images were reviewed and classified by two neuro radiologists. Clinical data including laboratory data, blood pressure, and discharge outcome were collected through review of existing electronic medical records. Characteristics of the two groups were compared. Six cases among 80 PRES patients displayed an atypical distribution of signal abnormality predominantly involving the infratentorial brain. In IPPRES patients, signal abnormalities within the supratentorial brain, when present, showed a predominantly central distribution rather than the typical peripheral distribution. IPPRES patients showed higher rates of extreme hypertension, renal dysfunction, abnormal serum calcium, and abnormal serum magnesium relative to typical PRES patients. Outcomes were similar between the two groups. In our small series, IPPRES differs from typical PRES patients not only in the distribution of imaging abnormalities but also in rates of extreme hypertension and several laboratory indices. Despite these differences, clinical outcome in the IPPRES group was similar to that of typical PRES.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Fitzgerald RT,Samant RS,Kumar M,Van Hemert R,Angtuaco EJdoi
10.1007/s13760-015-0431-2subject
Has Abstractpub_date
2015-12-01 00:00:00pages
629-34issue
4eissn
0300-9009issn
2240-2993pii
10.1007/s13760-015-0431-2journal_volume
115pub_type
杂志文章abstract：:In recent years, different research lines have examined the epileptogenic process in order to understand the different stages in this process, and with the hope that early recognition and intervention could prevent chronic epilepsy in patients with epileptic seizures. In animals, acquired epilepsy is studied most comm...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
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pub_type： 杂志文章,评审
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journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
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journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
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doi：
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