Abstract:
:Alpha 1-antichymotrypsin (ACT), an acute-phase protein, has been reported to be increased in the brain and blood of Alzheimer's disease (AD) patients. However, few previous studies have focused on amnestic mild cognitive impairment (aMCI) patients. The aim of our study was to investigate the changing trend in ACT concentrations during the progression of aMCI. Hence, we measured the cerebrospinal fluid (CSF) and serum levels of ACT in aMCI subjects and normal controls (NC) at 2-year follow-up assessments using ELISA and Western blot. Forty-four NCs, 28 stable aMCI (sMCI) patients, and 20 progressive aMCI (pMCI) patients finished the follow-up assessments, and their data were used for analysis. We found that CSF and serum ACT levels of both sMCI and pMCI patients increased over time, while those of NCs remained stable; CSF and serum ACT levels were significantly higher in both sMCI and pMCI patients than in NCs, except for baseline serum ACT. In pMCI patients prior to developing AD, CSF and serum ACT levels were already significantly higher than those in sMCI patients. The ROC curve results demonstrated that combining CSF and serum ACT levels can distinguish aMCI patients from NCs with high specificity and sensitivity. Our data suggest that ACT may be a biomarker for diagnosing aMCI.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Liu S,Pan J,Tang K,Lei Q,He L,Cai X,Li Zdoi
10.1007/s13760-019-01206-3subject
Has Abstractpub_date
2019-09-07 00:00:00eissn
0300-9009issn
2240-2993pii
10.1007/s13760-019-01206-3pub_type
杂志文章abstract::A 54-year-old female patient presented acute hallucinatory psychotic episodes with irritative EEG for seven years before an initial state of complex partial mal. A single convulsive episode occurred 14 years after the beginning of the psychiatric symptoms. The intercritical EEG showed independent temporal lobe foci pr...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Diets that have effects on health problems can vary in their composition. Whilst following a regular diet (RD) a person typically consumes about 30% of calories from fat. Ketogenic diet (KD) is a form of diet whereby a person consumes as much as 90% of calories from fat. KD has been trialed as a treatment for neurolog...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-020-01486-0
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abstract::Short-term cyclophosphamide pulse therapy was administered to five patients with idiopathic inflammatory myopathies (IIM) which were refractory to corticosteroids and, in two cases, to other aggressive therapies. Both disease remission and a reduction in corticosteroid dosage were obtained in four patients. Three of t...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::Headache is one of the chronic disorders that can trigger sexual dysfunction due to complex mechanisms. This study recruited 120 consecutive patients from our outpatient clinics with migraine (n = 60), TTH (n = 60) as well as healthy age-matched controls (n = 60) for a total of 180 patients. All the participants were ...
journal_title:Acta neurologica Belgica
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doi:10.1007/s13760-020-01504-1
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Non-traumatic dural arteriovenous fistula/malformation (dural AVF/AVM) presenting with pure subdural hematoma (SDH) is relatively rare. We report on a male patient who showed pure acute SDH and was diagnosed as having dural AVF on the convexity near the superior sagittal sinus (SSS), based on angiographic findings. A ...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2010-06-01 00:00:00
abstract::This retrospective study was performed to reevaluate the effect of polytherapy on mood and cognitive function. 139 patients with refractory epilepsy were screened with a neuropsychological test battery and a depression score. Our regression model with age at admission, duration of the disorder and number of antiepilep...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:A retrospective evaluation of the ictal temporal tracer uptake and the perfusion pattern in other neo- and subcortical structures was performed to define typical extratemporal changes of rCBF that might further aid the differentiation of temporal and extratemporal seizures. METHOD:Ictal and interictal rCBF bra...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::A knowledge of the mechanisms used in adaptation to vestibular lesions is important for both diagnostic and therapeutic purposes. Here we discuss commonly encountered circumstances--habitual wearing of spectacles, unilateral or bilateral labyrinthine dysfunction--that call for adaptation. The context specificity of ve...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-020-01417-z
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-017-0817-4
更新日期:2017-12-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-012-0164-4
更新日期:2013-09-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-017-0772-0
更新日期:2017-09-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::The aim of this study was to investigate retinal nerve fiber layer (RNFL) thickness and macular changes (central subfield thickness, cube average thickness, cube volume) in patients with chronic migraine (CM) without visual impairment using spectral-domain optical coherence tomography (SD-OCT) and to compare the resul...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-012-0150-x
更新日期:2013-06-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-020-01366-7
更新日期:2020-05-18 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-013-0270-y
更新日期:2014-06-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-020-01407-1
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-020-01274-w
更新日期:2020-04-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:10.1007/s13760-012-0174-2
更新日期:2013-09-01 00:00:00
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract:: ...
journal_title:Acta neurologica Belgica
pub_type: 信件
doi:10.1007/s13760-018-0979-8
更新日期:2019-03-01 00:00:00
abstract::Central hypoventilation in adult patients is a rare life-threatening condition characterised by the loss of automatic breathing, more pronounced during sleep. In most cases, it is secondary to a brainstem lesion or to a primary pulmonary, cardiac or neuromuscular disease. More rarely, it can be a manifestation of cong...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章,评审
doi:10.1007/s13760-020-01363-w
更新日期:2020-04-25 00:00:00
abstract::Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) is involved in the pathogenesis of central nervous system (CNS) demyelination disorders. We aimed to explore the spectrum of MOG-Ab-associated diseases in eastern India. A single-center, prospective observational study was done over a period of 2 years in a tertiar...
journal_title:Acta neurologica Belgica
pub_type: 杂志文章
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journal_title:Acta neurologica Belgica
pub_type: 杂志文章
doi:
更新日期:2011-06-01 00:00:00