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Requirement of heart and neural crest derivatives-expressed transcript 2 during decidualization of human endometrial stromal cells in vitro.

Abstract：

OBJECTIVE:To investigate the role of heart and neural crest derivatives-expressed transcript 2 (HAND2) during decidualization of human endometrial stromal cells (ESCs). DESIGN:In vitro experiment. SETTING:Research laboratory. PATIENT(S):Twenty-six patients undergoing hysterectomy for benign reasons. INTERVENTION(S):ESCs were cultured for 12 days with HAND2 small interfering RNA (siRNA) or nonsilencing RNA during decidualization by medroxyprogesterone acetate (MPA) and E2. MAIN OUTCOME MEASURE(S):Decidualization was monitored by changes in cellular morphology and the expression of several decidual-specific genes. RESULT(S):HAND2 siRNA effectively suppressed HAND2 levels in ESCs after 12 days of E2 + MPA treatment. ESCs cultured with HAND2 siRNA retained a long fibroblast-like shape, whereas the cells cultured with control siRNA transformed into enlarged polygonal cells. Silencing of HAND2 expression significantly reduced connexin-43 involved in the morphologic changes. HAND2 silencing significantly reduced the mRNA levels of fibulin-1, prolactin, tissue inhibitor of metalloproteinase 3, interleukin-15, and forkhead box O1A (FOXO1A), but had no effect on the mRNA levels of dickkopf-1, serum glucocorticoid kinase 1, and insulin-like growth factor-binding protein 5. HAND2 siRNA effectively suppressed the levels of nuclear FOXO1A protein as a regulator of decidualization. CONCLUSION(S):These results suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human ESCs.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Shindoh H,Okada H,Tsuzuki T,Nishigaki A,Kanzaki H

doi

10.1016/j.fertnstert.2014.03.013

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

1781-90.e1-5

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(14)00254-4

journal_volume

101

pub_type

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