Abstract:
:Non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), leading to fibrosis and potentially cirrhosis, and it is one of the most common causes of liver disease worldwide. NAFLD is associated with other medical conditions such as metabolic syndrome, obesity, cardiovascular disease and diabetes. NASH can only be diagnosed through liver biopsy, but noninvasive techniques have been developed to identify patients who are most likely to have NASH or fibrosis, reducing the need for liver biopsy and risk to patients. Disease progression varies between individuals and is linked to a number of risk factors. Mechanisms involved in the pathogenesis are associated with diet and lifestyle, influx of free fatty acids to the liver from adipose tissue due to insulin resistance, hepatic oxidative stress, cytokines production, reduced very low-density lipoprotein secretion and intestinal microbiome. Weight loss through improved diet and increased physical activity has been the cornerstone therapy of NAFLD. Recent therapies such as pioglitazone and vitamin E have been shown to be beneficial. Omega 3 polyunsaturated fatty acids and statins may offer additional benefits. Bariatric surgery should be considered in morbidly obese patients. More research is needed to assess the impact of these treatments on a long-term basis. The objective of this article is to briefly review the diagnosis, management and treatment of this disease in order to aid clinicians in managing these patients.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Schwenger KJ,Allard JPdoi
10.3748/wjg.v20.i7.1712subject
Has Abstractpub_date
2014-02-21 00:00:00pages
1712-23issue
7eissn
1007-9327issn
2219-2840journal_volume
20pub_type
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.14.6254
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v16.i27.3445
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v12.i32.5234
更新日期:2006-08-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v9.i6.1374
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3748/wjg.v11.i6.797
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journal_title:World journal of gastroenterology
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doi:10.3748/wjg.v13.i8.1295
更新日期:2007-02-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v11.i44.6960
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pub_type: 杂志文章
doi:10.3748/wjg.v25.i34.5105
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journal_title:World journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-08-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 社论,评审
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pub_type: 社论,评审
doi:10.3748/wjg.v23.i16.2819
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.15.919
更新日期:2009-02-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.14.6115
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.15.373
更新日期:2009-01-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v21.i10.2926
更新日期:2015-03-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v10.i14.2039
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v20.i11.2771
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v11.i35.5573
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pub_type: 评论,信件
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pub_type: 杂志文章
doi:10.3748/wjg.v17.i15.2007
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v26.i34.5220
更新日期:2020-09-14 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2017-01-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 社论,评审
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更新日期:2015-12-28 00:00:00