Abstract：
:Kaposis's sarcoma associated herpesvirus (KSHV) has been reported to infect, among others, monocytes and dendritic cells DCs impairing their function. However, the underlying mechanisms remain not completely elucidated yet. Here we show that DC exposure to active or UV-inactivated KSHV resulted in STAT3 phosphorylation. This effect, partially dependent on KSHV-engagement of DC-SIGN, induced a high release of IL-10, IL-6 and IL-23, cytokines that in turn might maintain STAT3 in a phosphorylated state. STAT3 activation also correlated with a block of autophagy in DCs, as indicated by LC3II reduction and p62 accumulation. The IL-10, IL-6 and IL-23 release and the autophagic block could be overcome by inhibiting STAT3 activation, highlighting the role of STAT3 in mediating such effects. In conclusion, here we show that STAT3 activation can be one of the molecular mechanisms leading to KSHV-mediated DC dysfunction, that might allow viral persistence and the onset of KSHV-associated malignancies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Santarelli R,Gonnella R,Di Giovenale G,Cuomo L,Capobianchi A,Granato M,Gentile G,Faggioni A,Cirone Mdoi
10.1038/srep04241subject
Has Abstractpub_date
2014-02-28 00:00:00pages
4241issn
2045-2322pii
srep04241journal_volume
4pub_type
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