Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Park J,Wang Q,Wu Q,Mao-Draayer Y,Kim CHdoi
10.1038/s41598-019-54276-xsubject
Has Abstractpub_date
2019-11-20 00:00:00pages
17511issue
1issn
2045-2322pii
10.1038/s41598-019-54276-xjournal_volume
9pub_type
已发布勘误abstract::Promoter activation drives gene transcriptional output. Here we report generating site-specifically integrated single-copy promoter transgenes and measuring their expression to indicate promoter activities at single-mRNA level. mRNA counts, Pol II density and Pol II firing rates of the Ccnb1 promoter transgene resembl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02240-y
更新日期:2017-05-18 00:00:00
abstract::Oysters are unusual among bivalves in that they possess chambers, often filled with soft, chalky calcite, that are irregularly scattered throughout the shell. Because the function of these so-called chalky deposits is still unclear, evaluating the growth and distribution of chalk is important for elucidating the ecolo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68726-4
更新日期:2020-07-21 00:00:00
abstract::Abnormal expression of microRNAs (miRNAs) contributes to glioma initiation. However, the expression of miRNAs in tumour tissue or blood of spinal cord glioma (SCG) patients, particularly in high-grade spinal gliomas (Grade IV) known as glioblastoma (GBM), remains largely unknown. In this study we aimed to determine di...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42364-x
更新日期:2019-06-24 00:00:00
abstract::Network analysis is an important tool to analyze the structure of complex systems such as tropical forests. Here, we infer spatial proximity networks in tropical forests by using network science. First, we focus on tree neighborhoods to derive spatial tree networks from forest inventory data. In a second step, we cons...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70052-8
更新日期:2020-08-06 00:00:00
abstract::A record 500,000 hectares burned in Portugal during the extreme wildfire season of 2017, with more than 120 human lives lost. Here we analyse the climatic factors responsible for the burned area (BA) from June to October series in Portugal for the period 1980-2017. Superposed onto a substantially stationary trend on B...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50281-2
更新日期:2019-10-10 00:00:00
abstract::Clostridioides difficile is the leading cause of nosocomial infections and a worldwide urgent public health threat. Without doubt, there is an urgent need for new effective anticlostridial agents due to the increasing incidence and severity of C. difficile infection (CDI). The aim of the present study is to investigat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64882-9
更新日期:2020-05-07 00:00:00
abstract::Most of Quantum Secret Sharing(QSS) are (n, n) threshold 2-level schemes, in which the 2-level secret cannot be reconstructed until all n shares are collected. In this paper, we propose a (t, n) threshold d-level QSS scheme, in which the d-level secret can be reconstructed only if at least t shares are collected. Comp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06486-4
更新日期:2017-07-25 00:00:00
abstract::The impact of statin therapy on plasma asymmetric dimethylarginine (ADMA) levels has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of statins on circulating ADMA levels. We searched selected databases (up to August 2014) to identify randomized controlled trials (RCTs) t...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep09902
更新日期:2015-05-13 00:00:00
abstract::CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily, binds to CD40, leading to many effects depending on target cell type. Platelets express CD40L and are a major source of soluble CD40L. CD40L has been shown to potentiate platelet activation and thrombus formation, involving both CD40-depende...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17189-1
更新日期:2017-12-07 00:00:00
abstract::A p-i-n junction diode constructed by the locally doped network of single-walled carbon nanotubes (SWNTs) was investigated. In this diode, the two opposite ends of the SWNT-network channel were selectively doped by triethyloxonium hexachloroantimonate (OA) and polyethylenimine (PEI) to obtain the air-stable p- and n-t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23319
更新日期:2016-03-21 00:00:00
abstract::In this study we report the enhancement of UV photodetection and wavelength tunable light induced NO gas sensing at room temperature using Au-ZnO nanocomposites synthesized by a simple photochemical process. Plasmonic Au-ZnO nanostructures with a size less than the incident wavelength have been found to exhibit a loca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06483
更新日期:2014-09-26 00:00:00
abstract::We investigate, for the first time, navigation on networks with a Lévy walk strategy such that the step probability scales as pij ~ dij(-α), where dij is the Manhattan distance between nodes i and j, and α is the transport exponent. We find that the optimal transport exponent α(opt) of such a diffusion process is dete...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17309
更新日期:2015-11-25 00:00:00
abstract::Mucosal associated invariant T (MAIT) cells are important for immune defense against infectious pathogens and regulate the pathogenesis of various inflammatory diseases. However, their roles in the development of colorectal cancer (CRC) are still unclear. This study examined the phenotype, distribution, clinical relev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20358
更新日期:2016-02-03 00:00:00
abstract::Fat character is an important index in duck culture that linked to local flavor, feed cost and fat intake for costumers. Since the regulation networks in duck lipid metabolism had not been reported very clearly, we aimed to explore the potential miRNA-mRNA pairs and their regulatory roles in duck lipid metabolism. Her...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27418
更新日期:2016-06-08 00:00:00
abstract::Ultrafast thermomechanical responses and spallation behaviours of monocrystal copper films irradiated by femtosecond laser pulse are investigated using molecular dynamics simulation (MDS). Films with 〈100〉, 〈110〉 and 〈111〉 crystal orientations along the thickness direction were studied. The results show that the cryst...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09559-6
更新日期:2017-08-23 00:00:00
abstract::GPS-derived Total Electron Content (TEC) is an integrated quantity; hence it is difficult to relate the detection of ionospheric perturbations in TEC to a precise altitude. As TEC is weighted by the maximum ionospheric density, the corresponding altitude (hmF2) is, generally, assumed as the perturbation detection alti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30476-9
更新日期:2018-08-14 00:00:00
abstract::The microbiota colonized on human body is renowned as "a forgotten organ" due to its big impacts on human health and disease. Recently, microbiome studies have identified a large number of microbes differentially regulated in a variety of conditions, such as disease and diet. However, methods for discovering biologica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40200
更新日期:2017-01-10 00:00:00
abstract::We introduce QuEST, the Quantum Exact Simulation Toolkit, and compare it to ProjectQ, qHipster and a recent distributed implementation of Quantum++. QuEST is the first open source, hybrid multithreaded and distributed, GPU accelerated simulator of universal quantum circuits. Embodied as a C library, it is designed so ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47174-9
更新日期:2019-07-24 00:00:00
abstract::The aberrant accumulation of ubiquitinated protein aggregates in cells plays a critical role in the pathogenesis of several degenerative diseases, including Parkinson disease (PD) and cystic fibrosis (CF). In this study, we found that Ras GTPase-activating protein-binding protein 1 (G3BP1) inhibits ubiquitinated prote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46237-1
更新日期:2019-09-09 00:00:00
abstract::More than 12 GW of offshore wind turbines are currently in operation in European waters. To optimise the use of the marine areas, wind farms are typically clustered in units of several hundred turbines. Understanding wakes of wind farms, which is the region of momentum and energy deficit downwind, is important for opt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20389-y
更新日期:2018-02-01 00:00:00
abstract::Cold Syndrome and Hot Syndrome are thousand-year-old key therapeutic concepts in traditional Chinese medicine (TCM), which depict the loss of body homeostasis. However, the scientific basis of TCM Syndrome remains unclear due to limitations of current reductionist approaches. Here, we established a network balance mod...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01543
更新日期:2013-01-01 00:00:00
abstract::Bats of the Rhinolophidae and Hipposideridae families, and Pteronotus parnellii, compensate for Doppler shifts generated by their own flight movement. They adjust their call frequency such that the frequency of echoes coming from ahead fall in a specialized frequency range of the hearing system, the auditory fovea, to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22880-y
更新日期:2018-03-15 00:00:00
abstract::Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism independent of receptors whose...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41362
更新日期:2017-01-27 00:00:00
abstract::Harmaline (HAR), a natural occurrence β-carboline alkaloid, was isolated from the seeds of Peganum harmala and exhibited potent antitumor effect. In this study, the anti-gastric tumor effects of HAR were firstly investigated in vitro and in vivo. The results strongly showed that HAR could inhibit tumor cell proliferat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18613
更新日期:2015-12-18 00:00:00
abstract::Osmosis is the movement of solvent across a permselective membrane induced by a solute-concentration gradient. Now in 'Forward Osmosis' it is empirically observed that the diffusion of the solute is counter to that of the solvent i.e. there is so-called "reverse salt diffusion". However it has been recently suggested,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53417-6
更新日期:2019-11-11 00:00:00
abstract::Advanced electron microscopy technologies have made it possible to perform precise double-slit interference experiments. We used a 1.2-MV field emission electron microscope providing coherent electron waves and a direct detection camera system enabling single-electron detections at a sub-second exposure time. We devel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19380-4
更新日期:2018-01-17 00:00:00
abstract::The Synlestidae (Odonata: Zygoptera) of southern Africa comprise some highly localized species. All but one species are endemic to South Africa, and many to the Cape Floristic Region. Here we present the first phylogenetic reconstruction of the southern African Synlestidae using nuclear and mitochondrial molecular dat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72001-x
更新日期:2020-09-15 00:00:00
abstract::A chronic antigenic stimulation is believed to sustain the leukemogenic development of chronic lymphocytic leukemia (CLL) and most of lymphoproliferative malignancies developed from mature B cells. Reproducing a proliferative stimulation ex vivo is critical to decipher the mechanisms of leukemogenesis in these maligna...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36853-8
更新日期:2019-01-24 00:00:00
abstract::We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Science was conducted to obtain relevant publications. Finally a total of 1...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep24812
更新日期:2016-04-20 00:00:00
abstract::Electrophysiological field potential dynamics have been widely used to investigate brain functions and related psychiatric disorders. Considering recent demand for its applicability to freely moving subjects, especially for animals in a group and socially interacting with each other, here we propose a new method based...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43897-x
更新日期:2019-05-16 00:00:00