Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:Parastrephia lucida (Meyen) Cabrera is used in the traditional medicine of Argentinean highlands as an antiseptic and anti-inflammatory medicinal plant. To give scientific support to the ethnopharmacological claim of Parastrephia lucida as an anti-inflammatory crude drug the effect of Parastrephia lucida extracts and fractions was assessed on key enzymes of the biosynthesis of pro-inflammatory eicosanoids mediators from arachidonic acid (AA). MATERIALS AND METHODS:A bio-guided fractionation of the plant extract was carried out to find out the compounds or mixtures responsible for the anti-inflammatory effect. The extracts and fractions were tested in vitro for their ability to inhibit the enzymes cyclooxygenase (COX)-1 and COX-2, lipoxygenase (LOX) and phospholipase (sPLA2). Fractions were analyzed by HPLC-MS, HPLC-ESI-MS/MS and NMR to relate the effect with groups of secondary metabolites. RESULTS:Parastrephia lucida was more effective inhibiting COX and sPLA2 than LOX. Assay-guided isolation led to the active fractions C and F which showed different effect on the selected enzymes. The fraction C was more effective inhibiting LOX while fraction F showed better activity against sPLA2 and COX-2. Both fractions were further worked-up following the isolation of the anti-inflammatory agents with the selected enzyme assays. The main compounds identified in the most active fractions were 5,4′-dihydroxi-7-methoxyflavanone, apigenin, apigenin methyl ether and apigenin trimethyl ether, methyl and dimethyl ethers from quercetin, kaempferol and luteolin methyl ether, ferulic acid esters, cinnamic acid and vanillin. CONCLUSIONS:Parastrephia lucida extract inhibit AA metabolism via several enzymes. The results give support to the traditional use of this plant for the treatment of inflammatory disorders.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
D'Almeida RE,Isla MI,Vildoza Ede L,Quispe C,Schmeda-Hirschmann G,Alberto MRsubject
Has Abstractpub_date
2013-12-12 00:00:00pages
1080-6issue
3eissn
0378-8741issn
1872-7573pii
S0378-8741(13)00721-6journal_volume
150pub_type
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