Abstract：
:Individual proteomes typically differ from the reference human proteome at ∼10,000 single amino acid variants. When viewed on the population scale, this individual variation results in a wide variety of protein sequences. In targeted proteomics experiments, such variability can confound accurate protein quantification. To assist researchers in identifying target peptides with high variability within the human population, we have created the Population Variation plug-in for Skyline, which provides easy access to the polymorphisms stored in dbSNP. Given a set of peptides, the tool reports minor allele frequency for common polymorphisms. We highlight the importance of considering genetic variation by applying the tool to public data sets.
journal_name
J Proteome Resjournal_title
Journal of proteome researchauthors
Fujimoto GM,Monroe ME,Rodriguez L,Wu C,MacLean B,Smith RD,MacCoss MJ,Payne SHdoi
10.1021/pr4011052subject
Has Abstractpub_date
2014-01-03 00:00:00pages
321-3issue
1eissn
1535-3893issn
1535-3907journal_volume
13pub_type
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journal_title：Journal of proteome research
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更新日期：2018-06-01 00:00:00
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journal_title：Journal of proteome research
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journal_title：Journal of proteome research
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journal_title：Journal of proteome research
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journal_title：Journal of proteome research
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pub_type： 杂志文章
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更新日期：2011-08-05 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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更新日期：2008-11-01 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
doi：10.1021/pr200842h
更新日期：2012-02-03 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2013-06-07 00:00:00
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journal_title：Journal of proteome research
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更新日期：2009-06-01 00:00:00
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journal_title：Journal of proteome research
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doi：10.1021/pr500597a
更新日期：2014-12-05 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
doi：10.1021/acs.jproteome.7b00474
更新日期：2017-10-06 00:00:00
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更新日期：2005-11-01 00:00:00
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更新日期：2014-09-05 00:00:00
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journal_title：Journal of proteome research
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更新日期：2009-04-01 00:00:00
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journal_title：Journal of proteome research
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更新日期：2008-01-01 00:00:00
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