Principal component analysis of the conformational freedom within the EF-hand superfamily.

Abstract:

:A database of nonredundant structures of EF-hand domains--i.e., pairs of helix-loop-helix motifs--has been assembled, and the six angles among the four helices re-determined. A principal component analysis of these angles allows us to use two such components (PC1 and PC2) to describe the system retaining 80% of the total variance. A PC2 against PC1 plot representation allows us to represent in a compact way the full range of structural diversity of EF-hand domains, their grouping into protein families, and the variation for each family upon calcium and peptide binding.

journal_name

J Proteome Res

authors

Babini E,Bertini I,Capozzi F,Luchinat C,Quattrone A,Turano M

doi

10.1021/pr050148n

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

1961-71

issue

6

eissn

1535-3893

issn

1535-3907

journal_volume

4

pub_type

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