Abstract:
:A database of nonredundant structures of EF-hand domains--i.e., pairs of helix-loop-helix motifs--has been assembled, and the six angles among the four helices re-determined. A principal component analysis of these angles allows us to use two such components (PC1 and PC2) to describe the system retaining 80% of the total variance. A PC2 against PC1 plot representation allows us to represent in a compact way the full range of structural diversity of EF-hand domains, their grouping into protein families, and the variation for each family upon calcium and peptide binding.
journal_name
J Proteome Resjournal_title
Journal of proteome researchauthors
Babini E,Bertini I,Capozzi F,Luchinat C,Quattrone A,Turano Mdoi
10.1021/pr050148nkeywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
1961-71issue
6eissn
1535-3893issn
1535-3907journal_volume
4pub_type
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