Interaction network of the 14-3-3 protein in the ancient protozoan parasite Giardia duodenalis.

abstract：:Genetically identical cloned pigs should in principle eliminate biological variation and provide more pronounced effects when subjected to, e.g., dietary interventions, but little is known about how phenotype and phenotypic variation is affected by cloning. Therefore, an investigation of the metabolome of cloned pigs ...

journal_title：Journal of proteome research

authors： Christensen KL,Hedemann MS,Jørgensen H,Stagsted J,Knudsen KE

更新日期：2012-07-06 00:00:00

abstract：:Pinus radiata is one of the most economically important forest tree species, with a worldwide production of around 370 million m (3) of wood per year. Current selection of elite trees to be used in conservation and breeding programes requires the physiological and molecular characterization of available populations. T...

journal_title：Journal of proteome research

authors： Valledor L,Castillejo MA,Lenz C,Rodríguez R,Cañal MJ,Jorrín J

更新日期：2008-07-01 00:00:00

abstract：:The low selectivity of Kv1 peptide inhibitors for specific isoforms makes them poor candidates for the development of theraputics. Using combined approaches, we showed that the Kv1 turret is the critical determinant for ADWX-1 peptide inhibitor selectivity of Kv1.3 over Kv1.1. Mutation of Kv1.1 turret residues to matc...

journal_title：Journal of proteome research

authors： Yin SJ,Jiang L,Yi H,Han S,Yang DW,Liu ML,Liu H,Cao ZJ,Wu YL,Li WX

更新日期：2008-11-01 00:00:00

abstract：:We have investigated whether postexercise ingestion of carbohydrates in combination with proteins generates a different systemic metabolic response, as compared to the sole ingestion of carbohydrate or water, in the early recovery phase following exercise. In addition, metabolic patterns related to fitness level were ...

journal_title：Journal of proteome research

authors： Chorell E,Moritz T,Branth S,Antti H,Svensson MB

更新日期：2009-06-01 00:00:00

abstract：:We have developed a novel approach to enhance phosphopeptide identification in liquid chromatography/mass spectrometry (LC/MS)-based phosphoproteomics. After enrichment of phosphopeptides with immobilized metal affinity chromatography (IMAC) and titanium dioxide (TiO(2)) microcolumns, samples were coinjected with ethy...

journal_title：Journal of proteome research

authors： Nakamura T,Myint KT,Oda Y

更新日期：2010-03-05 00:00:00

abstract：:Major depressive disorder (MDD) is a debilitating mental disease with a pronounced impact on the quality of life of many people; however, it is still difficult to diagnose MDD accurately. In this study, a nontargeted metabolomics approach based on ultra-high-performance liquid chromatography equipped with quadrupole t...

journal_title：Journal of proteome research

authors： Liu X,Zheng P,Zhao X,Zhang Y,Hu C,Li J,Zhao J,Zhou J,Xie P,Xu G

更新日期：2015-05-01 00:00:00

abstract：:Molecular imaging of tissue by MALDI mass spectrometry is a powerful tool for visualizing the spatial distribution of constituent analytes with high molecular specificity. Although the technique is relatively young, it has already contributed to the understanding of many diverse areas of human health. In recent years,...

journal_title：Journal of proteome research

authors： Chaurand P,Norris JL,Cornett DS,Mobley JA,Caprioli RM

更新日期：2006-11-01 00:00:00

abstract：:The development of medical interventions for the preservation of disease-free longevity would be facilitated by markers that predict healthy aging. Altered protein N-glycosylation patterns have been found with increasing age and several disease states. Here we investigate whether glycans derived from the total glycopr...

journal_title：Journal of proteome research

authors： Ruhaak LR,Uh HW,Beekman M,Hokke CH,Westendorp RG,Houwing-Duistermaat J,Wuhrer M,Deelder AM,Slagboom PE

更新日期：2011-04-01 00:00:00

abstract：:We successfully modified an existing method to investigate protein-protein interactions in the pathogenic bacterium Salmonella enterica serovar Typhimurium (Salmonella Typhimurium). This method includes (i) addition of a histidine-biotin-histidine tag to the bait proteins via recombinant DNA techniques, (ii) in vivo c...

journal_title：Journal of proteome research

authors： Chowdhury SM,Shi L,Yoon H,Ansong C,Rommereim LM,Norbeck AD,Auberry KJ,Moore RJ,Adkins JN,Heffron F,Smith RD

更新日期：2009-03-01 00:00:00

abstract：:Biomarkers for colorectal cancer (CRC) early diagnosis are currently lacking. The purpose of this study was to interpret molecular events in the early stage of CRC that may bring about new biomarkers for early diagnosis. Methylation isotope labeling assistant gel-enhanced liquid chromatography-mass spectrometry (GeLC-...

journal_title：Journal of proteome research

authors： Xie LQ,Zhao C,Cai SJ,Xu Y,Huang LY,Bian JS,Shen CP,Lu HJ,Yang PY

更新日期：2010-09-03 00:00:00

abstract：:Hypoxia is present in most solid tumors and is clinically correlated with increased metastasis and poor patient survival. While studies have demonstrated the role of hypoxia and hypoxia-regulated proteins in cancer progression, no attempts have been made to identify hypoxia-regulated proteins using quantitative proteo...

journal_title：Journal of proteome research

authors： Djidja MC,Chang J,Hadjiprocopis A,Schmich F,Sinclair J,Mršnik M,Schoof EM,Barker HE,Linding R,Jørgensen C,Erler JT

更新日期：2014-05-02 00:00:00

abstract：:MS-based de novo peptide sequencing has been improved remarkably with significant development of mass-spectrometry and computational approaches but still lacks quality-control methods. Here we proposed a novel algorithm pSite to evaluate the confidence of each amino acid rather than the full-length peptides obtained b...

journal_title：Journal of proteome research

authors： Yang H,Chi H,Zhou WJ,Zeng WF,Liu C,Wang RM,Wang ZW,Niu XN,Chen ZL,He SM

更新日期：2018-01-05 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer among women worldwide. It is confirmed mainly by fine-needle aspiration biopsy (FNAB), an invasive diagnostic method. The key proteins responsible for thyroid hormone biosynthesis are glycosylated. Hence, changes in site-specific glycosylation...

journal_title：Journal of proteome research

authors： Zhang Y,Zhao W,Zhao Y,Mao Y,Su T,Zhong Y,Wang S,Zhai R,Cheng J,Fang X,Zhu J,Yang H

更新日期：2020-07-02 00:00:00

abstract：:Proteoforms containing post-translational modifications (PTMs) represent a degree of functional diversity only harnessed through analytically precise simultaneous quantification of multiple PTMs. Here we present a method to accurately differentiate an unmodified peptide from its PTM-containing counterpart through data...

journal_title：Journal of proteome research

authors： Robinson AE,Binek A,Venkatraman V,Searle BC,Holewinski RJ,Rosenberger G,Parker SJ,Basisty N,Xie X,Lund PJ,Saxena G,Mato JM,Garcia BA,Schilling B,Lu SC,Van Eyk JE

更新日期：2020-10-02 00:00:00

abstract：:Proteomics methods are being increasingly used to study archaeological and palaeontological bone, assisting in species identification and phylogenetic studies as well as improving our understanding of bone diagenesis. More recently, there are developing interests in the study of post-translational modifications, some ...

journal_title：Journal of proteome research

authors： Procopio N,Buckley M

更新日期：2017-02-03 00:00:00

abstract：:Correct phosphorylation site assignment is a critical aspect of phosphoproteomic analysis. Large-scale phosphopeptide data sets that are generated through liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) analysis often contain hundreds or thousands of phosphorylation sites that require validation. To ...

journal_title：Journal of proteome research

authors： Ruttenberg BE,Pisitkun T,Knepper MA,Hoffert JD

更新日期：2008-07-01 00:00:00

abstract：:Plant secretory (Class III) peroxidases are redox enzymes that rely on N-glycosylation for full enzyme activity and stability. Peroxidases from palm tree leaves comprise the most stable and active plant peroxidases characterized to date. Herein, site-specific glycosylation and microheterogeneity of windmill palm tree ...

journal_title：Journal of proteome research

authors： Baker MR,Tabb DL,Ching T,Zimmerman LJ,Sakharov IY,Li QX

更新日期：2016-06-03 00:00:00

abstract：:Neurodegenerative diseases are often defined pathologically by the presence of protein aggregates. These aggregates, including amyloid plaques in Alzheimer's disease (AD), result from the abnormal accumulation and processing of proteins, and may ultimately lead to neuronal dysfunction and cell death. To date, conventi...

journal_title：Journal of proteome research

authors： Gozal YM,Duong DM,Gearing M,Cheng D,Hanfelt JJ,Funderburk C,Peng J,Lah JJ,Levey AI

更新日期：2009-11-01 00:00:00

abstract：:Peptide abundance estimation is generally the first step in protein quantification. In peptide abundance estimation, peptide overlapping and peak intensity variation are two challenges. The main objective of this paper is to estimate peptide abundance by taking advantage of peptide isotopic distribution and smoothness...

journal_title：Journal of proteome research

authors： Yang C,Yang C,Yu W

更新日期：2010-05-07 00:00:00

abstract：:Cyadox is an antibiotic drug and has the potential to be used as a feedstuff additive in promoting the growth of animals. However, the toxicity of cyadox should be fully assessed before application, and this has prompted the current investigation on the metabolic responses of mice to cyadox exposure, using a metabonom...

journal_title：Journal of proteome research

authors： Huang C,Lei H,Zhao X,Tang H,Wang Y

更新日期：2013-01-04 00:00:00

abstract：:Mass spectrometry is being used to identify protein biomarkers that can facilitate development of drug treatment. Mass spectrometry-based labeling proteomic experiments result in complex proteomic data that is hierarchical in nature often with small sample size studies. The generalized linear model (GLM) is the most p...

journal_title：Journal of proteome research

authors： D'Angelo G,Chaerkady R,Yu W,Hizal DB,Hess S,Zhao W,Lekstrom K,Guo X,White WI,Roskos L,Bowen MA,Yang H

更新日期：2017-09-01 00:00:00

abstract：:Since 2012, missing proteins (MPs) investigation has been one of the critical missions of Chromosome-Centric Human Proteome Project (C-HPP) through various biochemical strategies. On the basis of our previous testis MPs study, faster scanning and higher resolution mass-spectrometry-based proteomics might be conducive ...

journal_title：Journal of proteome research

authors： Wei W,Luo W,Wu F,Peng X,Zhang Y,Zhang M,Zhao Y,Su N,Qi Y,Chen L,Zhang Y,Wen B,He F,Xu P

更新日期：2016-11-04 00:00:00

abstract：:Repeat administration of psychostimulants, such as methamphetamine, produces a progressive increase in locomotor activity (behavioral sensitization) in rodents that is believed to represent the underlying neurochemical changes driving psychoses. Alterations to the prefrontal cortex (PFC) are suggested to mediate the e...

journal_title：Journal of proteome research

authors： Wearne TA,Mirzaei M,Franklin JL,Goodchild AK,Haynes PA,Cornish JL

更新日期：2015-01-02 00:00:00

abstract：:Phytopathogenic fungi are one of the most damaging plant parasitic organisms, and can cause serious diseases and important yield losses in crops. The study of the biology of these microorganisms and the interaction with their hosts has experienced great advances in recent years due to the development of moderm, holist...

journal_title：Journal of proteome research

authors： Gonzalez-Fernandez R,Jorrin-Novo JV

更新日期：2012-01-01 00:00:00

abstract：:Label-free quantification of shotgun proteomics data is a frequently used strategy, offering high dynamic range, sensitivity, and the ability to compare a high number of samples without additional labeling effort. Here, we present a bioinformatics approach that significantly improves label-free quantification results....

journal_title：Journal of proteome research

authors： Doblmann J,Dusberger F,Imre R,Hudecz O,Stanek F,Mechtler K,Dürnberger G

更新日期：2019-01-04 00:00:00

abstract：:We describe a dual-column interface for parallel chromatography to improve throughput during LC-MS experimentation. The system employs a high-voltage switch to operate two capillary column/nanospray emitters fixed at the MS orifice. Sequentially loading one column while operating the second nearly doubles the LC-MS du...

journal_title：Journal of proteome research

authors： Orton DJ,Wall MJ,Doucette AA

更新日期：2013-12-06 00:00:00

abstract：:Aggregated and protease-resistant mammalian prion protein (PrPSc) is the primary protein component of infectious prions. Enriched PrPSc preparations are often used to study the mechanisms that underly prion disease. However, most enrichment procedures are relatively nonspecific and tend to yield significant amounts of...

journal_title：Journal of proteome research

authors： Moore RA,Choi YP,Head MW,Ironside JW,Faris R,Ritchie DL,Zanusso G,Priola SA

更新日期：2016-12-02 00:00:00

abstract：:The nation-wide electronic health record database acts as an interoperable repository of health data obtained throughout citizen contacts with health care providers. This system improves accessibility for citizens and researchers to health data with the ability to assign context to disease development. In that system,...

journal_title：Journal of proteome research

authors： Sepper R,Ross P,Tiik M

更新日期：2011-01-07 00:00:00

abstract：:Ozonated autohemotherapy (O3-AHT) is a medical approach during which blood obtained from the patient is ozonated and injected back into the body. Despite an increasing number of evidence that O3-AHT is safe, this type of therapy remains controversial. To extend knowledge about the changes in blood evoked by O3-AHT, LC...

journal_title：Journal of proteome research

authors： Ciborowski M,Lipska A,Godzien J,Ferrarini A,Korsak J,Radziwon P,Tomasiak M,Barbas C

更新日期：2012-12-07 00:00:00

abstract：:Oxidative stress and inflammation play a role in the physiopathology of insulin resistance, diabetes and cardiovascular disease. A single high-fat, high-carbohydrate (HFHC) meal induces an increase in inflammatory and oxidative stress markers in peripheral blood mononuclear cells (PBMC). Previous studies have shown th...

journal_title：Journal of proteome research

authors： Chaves DFS,Carvalho PC,Brasili E,Rogero MM,Hassimotto NA,Diedrich JK,Moresco JJ,Yates JR 3rd,Lajolo FM

更新日期：2017-11-03 00:00:00