Abstract：
OBJECTIVE:Reconstruction of large and complex bone segments is a challenging problem facing maxillofacial surgery. The majority of current regenerative approaches rely on extrinsic vascularization, which is deficient after cancer ablation and irradiation. The aim of the study was to investigate the efficacy of intrinsic axial vascularization of synthetic bone scaffolds in the management of critical-size mandibular defects. MATERIALS AND METHODS:Scaffold-guided mandibular regeneration in two groups of adult male goats was compared. Only the scaffolds of the second group were axially vascularized via in situ embedding of an arteriovenous loop through microsurgical anastomosis of facial vessels. After 6 months of follow up, both groups were compared through radiological, biomechanical, histological and histomorphometric analysis. RESULTS:The axially vascularized constructs have showed significantly more central vascularization (p = 0.021) and markedly enhanced central bone formation (p = 0.08). The biomechanical characteristics were enhanced, but the difference between both groups was not statistically significant (p = 0.98). CONCLUSIONS:Axially vascularized synthetic mandibular grafts show better vascularization at their central regions, permitting more efficient bone regeneration. CLINICAL RELEVANCE:The encouraging results of the proposed technique could be of benefit in optimizing the reconstruction of large critical-size bone defects.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Eweida AM,Nabawi AS,Abouarab M,Kayed M,Elhammady H,Etaby A,Khalil MR,Shawky MS,Kneser U,Horch RE,Nagy N,Marei MKdoi
10.1007/s00784-013-1143-8subject
Has Abstractpub_date
2014-07-01 00:00:00pages
1671-8issue
6eissn
1432-6981issn
1436-3771journal_volume
18pub_type
杂志文章abstract：OBJECTIVES:Τhis study aims at determining the ability of cone beam computed tomography (CBCT) to visualize critical-size defects (CSD) created at rat calvaria and filled with 75/25 w/w nano-hydroxyapatite/chitosan (nHAp/CS) scaffolds, prior to their histological investigation. MATERIALS AND METHODS:Thirty adult Spragu...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-02939-4
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:The study aimed at assessing, as primary objective, the periapical status and quality of root fillings, and, as secondary objective, the endodontic treatment need of a German urban population in a cross-sectional study 20 years after the first one. MATERIALS AND METHODS:Clinical and radiographic data of 353...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2566-z
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVES:Cell-free DNA (cfDNA) harboring mutations has been found in patients with diseases. Experimental studies have shown that cfDNA can be transmitted, leading to transformations in the host. In the present study, we evaluated whether bone allograft material contains cfDNA and whether this foreign cfDNA can be re...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-02867-3
更新日期：2019-12-01 00:00:00
abstract：AIM:The aim of this study was to compare the effectiveness of 2% articaine and 2% lignocaine in achieving adequate anesthesia in children between the age group of 6-13 years using inferior alveolar nerve block. METHODS:A triple blinded randomized controlled trial was conducted in 180 participants (90 patients- 2% arti...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-018-2775-5
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:The aim of this systematic review and meta-analysis (SRM) was to assess the postoperative pain (PP) after non-surgical endodontic retreatment (NSER) in a one visit compared to multiple visits. The PICO question used was "Does NSER in patients with unsatisfactory endodontic treatment in a one-visit visit have...
journal_title：Clinical oral investigations
pub_type： 杂志文章,meta分析
doi：10.1007/s00784-020-03767-7
更新日期：2021-02-01 00:00:00
abstract：OBJECTIVE:The present study aimed to identify and quantify the elution of monomers of five different resin-based CAD/CAM blocks (RCBs) using HPLC. METHODS:Five different RCBs were used in the study: GC Cerasmart (CS), Voco Grandio blocs (GR), 3M Lava Ultimate (LU), Shofu Block (SB), and Vita Enamic (VE). Fifteen sampl...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03377-3
更新日期：2021-01-01 00:00:00
abstract：: ...
journal_title：Clinical oral investigations
pub_type： 信件
doi：10.1007/s00784-018-2619-3
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to evaluate the bond strength of three root-end filling materials (MTAA-MTA Angelus, MTAS-experimental MTA Sealer, and ZOE- zinc oxide and eugenol cement) in retrograde preparations performed with different ultrasonic tips (CVD, Trinity, and Satelec). MATERIALS AND METHOD:Nin...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1708-9
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:This work aimed to study the role of inflammation in medication-related osteonecrosis of the jaw (MRONJ) in rats with focus on Wnt signaling. METHODS:A total of 36 female Wistar rats (12 weeks ± 200 g) were divided into 2 groups (n = 6) in 3 experiments: saline (SAL) and zoledronic acid (ZOL). For MRONJ indu...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03551-7
更新日期：2021-02-01 00:00:00
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journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-019-02845-9
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to assess whether alveolar ridge preservation (ARP) can reduce the need of ridge augmentation at posterior tooth sites. MATERIAL AND METHODS:This study enrolled patients who received dental implants at posterior tooth sites during 2013-2019. Demographic data and dental treatment hi...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-021-03778-y
更新日期：2021-01-11 00:00:00
abstract：OBJECTIVES:Numerous different attachments are used to retain overdentures on implants. The purpose of this study was to evaluate a new chairside attachment system based on polyvinylsiloxane (PVS). MATERIAL AND METHODS:A total of 250 specimens were fabricated (n = 10) to measure the retention force (RF) in dependence o...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1307-1
更新日期：2015-05-01 00:00:00
abstract：:This study assessed the Knoop hardness and temperature increase provided by three light curing units when using (1) the manufacturers' recommended times of photo-activation and (2) standardizing total energy density. One halogen--XL2500 (3M/ESPE)--and two light-emitting diode (LED) curing units--Freelight (3M/ESPE) an...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-005-0028-x
更新日期：2006-03-01 00:00:00
abstract：:Regular screening through white light inspection of the entire oral mucosa is the most important examination method to identify precancerous lesions and early oral carcinoma. Additionally, the physiologic autofluorescence of the oral mucosa has been described as a novel screening method for the detection of mucosal le...
journal_title：Clinical oral investigations
pub_type： 临床试验,杂志文章
doi：10.1007/s00784-010-0455-1
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To describe and explore the association between proxy-reported sleep bruxism (SB) and quality of life (QoL) in a population of Colombian children belonging to different social layers. METHODS:The parents of 1556, 6-13-year-old school children, were administered the Pediatric Inventory of Quality of Life (Ped...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-016-1901-5
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:To evaluate the marginal and internal fit of CAD/CAM-generated frameworks for 4-unit, fixed dental prostheses (FDPs) from zirconia (Z) and cobalt-chromium alloy (C) made with conventional (CI) and digital impressions (DI). MATERIALS AND METHODS:A titanium model was digitized with an intraoral scanner (DI, L...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1513-5
更新日期：2016-03-01 00:00:00
abstract：:In the course of a prospectively designed long-term clinical trial, composite fillings and inlays were evaluated for clinical acceptability as restorative materials in one, two or more surface cavities of posterior teeth over a 1-year period. In 45 patients, 88 restorations were placed by nine student operators, under...
journal_title：Clinical oral investigations
pub_type： 临床试验,杂志文章
doi：10.1007/s007840050013
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVES:Bony reconstruction of jaw defects using the free fibular flap and dental rehabilitation mostly requires insertion of dental implants within the transferred fibula bone. The aim of this paper was to discuss results of the implant stability with data on the possible benefit for the patient's quality of life a...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-015-1487-3
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to quantify the blue light that passes through different incremental thicknesses of bulk fill in comparison to conventional resin-based composites (RBCs) and to relate it to the induced mechanical properties. MATERIALS AND METHODS:Seven bulk fill, five nanohybrid and two flowable R...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-013-1177-y
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:It is well accepted that stage-specific embryonic antigen (SSEA)-4 is an antigen that is useful to isolate adult stem cells analogous to embryonic stem cells. Therefore, in the present study, we investigated whether SSEA-4 can also be used as a marker to identify human deciduous dental pulp (D-DP) stem cells...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-014-1260-z
更新日期：2015-03-01 00:00:00
abstract：:This study compared shear bond strengths of six self-adhesive resin cements to zirconium oxide ceramic with and without air-particle abrasion. One hundred twenty zirconia samples were air-abraded (group SB; n = 60) or left untreated (group NO). Composite cylinders were bonded to the zirconia samples with either BisCem...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-009-0278-0
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVES:The purpose of this randomized controlled trial was to compare the 24-month success rates of indirect pulp treatment (IPT) and iRoot BP Plus pulpotomy of primary molars with extremely deep caries. MATERIALS AND METHODS:Generally healthy children aged 3-7 years requiring general anesthesia for treating prima...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03627-4
更新日期：2020-10-15 00:00:00
abstract：OBJECTIVE:The objective of this study was to evaluate impact of periodontal surgery on periodontal health and on glycaemia control of type 1 and type 2 (T1DM; T2DM) diabetics with severe periodontitis, during 12 months follow-up, in comparison with non-diabetic controls. MATERIALS AND METHODS:A total of 23 T1DM and 10...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-016-1819-y
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:Ventilator-associated pneumonia (VAP) is the most frequent hospital-acquired infections in intensive care units (ICU). In the bundle of care to prevent the VAP, the oral care is very important strategies, to decrease the oropharyngeal bacterial colonization and presence of causative bacteria of VAP. In view ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-017-2289-6
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:The aim of this prospective, randomized, clinical study was to assess the effect of photobiomodulation therapy (PBM) with low-level laser irradiation (LLLI) on postoperative pain after endodontic treatment. MATERIALS AND METHODS:Sixty patients, diagnosed with irreversible pulpitis in lower molar teeth, parti...
journal_title：Clinical oral investigations
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00784-018-2435-9
更新日期：2019-01-01 00:00:00
abstract：:We determined the effects of soluble or coated nanocrystalline hydroxyapatite paste (nano-HA) and enamel matrix derivative (EMD) on proliferation, adhesion, and migration of periodontal ligament fibroblasts (PDLs). Cultured PDLs were stimulated with nano-HA paste or EMD in a soluble form or were coated to the surface ...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-011-0570-7
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess the effects of three different fluoride-releasing agents on preventing white spot lesions that occur during treatment with full coverage rapid maxillary expanders. MATERIALS AND METHODS:A total of 48 patients with transverse maxillary deficiency were randomly assigned to f...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2749-7
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML). SUBJECTS AND METHODS:Whole unstimulated saliva samples were collected from age-, sex-, and race-m...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-018-2777-3
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the effect of different endodontic solvents on the microtensile bond strength (μTBS) of various adhesives to pulp chamber dentin. MATERIAL AND METHODS:A total of 120 human third molars were selected. Canals were prepared with the ProTaper Universal system and obturated....
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-016-1929-6
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVES:Resin-based composites may leach monomers such as triethylene-glycol dimethacrylate (TEGDMA), which could contribute to intrapulpal inflammation. The aim of this investigation was to examine whether various concentrations of TEGDMA are able to influence dentally relevant Matrix metalloproteinase (MMP)-2, MMP...
journal_title：Clinical oral investigations
pub_type： 杂志文章
doi：10.1007/s00784-020-03545-5
更新日期：2020-08-26 00:00:00
