当前位置： SCI文献检索 > EUROPEAN JOURNAL OF RADIOLOGY期刊下所有文献 > Measurement of the apparent diffusion coefficient in paediatric mitochondrial encephalopathy cases and a comparison of parenchymal changes associated with the disease using follow-up diffusion coefficient measurements.

Measurement of the apparent diffusion coefficient in paediatric mitochondrial encephalopathy cases and a comparison of parenchymal changes associated with the disease using follow-up diffusion coefficient measurements.

Abstract：

OBJECTIVES:To reveal the contribution of MRI and diffusion-weighted imaging (DWI) to the diagnosis of mitochondrial encephalopathy (ME) and to evaluate the parenchymal changes associated with this disease in the involved parenchymal areas using the apparent diffusion coefficient (ADC) parameter. METHODS:Ten patients who had undergone MRI and DWI analysis with a pre-diagnosis of neurometabolic disease, and who were subsequently diagnosed with ME in laboratory and/or genetic studies, were included in our study. ADC values were compared with a control group composed of 20 patients of similar age with normal brains. Evaluations involved measurements made in 20 different areas determined on the ADC map. The dominance or contribution of ADC coefficient measurements to the conventional sequences was compared with the controls. RESULTS:In the first examination, an increase in both diffusion and ADC values was detected in six cases and diffusion restriction and a decrease in ADC values in three patients. While an increase in both diffusion and ADC values was demonstrated in four cases, there was diffusion restriction and a decrease in ADC values in three cases in the control examinations. CONCLUSIONS:DWI provides information that complements conventional MRI sequences in the diagnosis of ME.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Uysal F,Cakmakçı H,Yiş U,Ellidokuz H,Hız AS

doi

10.1016/j.ejrad.2013.06.031

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

212-8

issue

1

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(13)00534-2

journal_volume

83

pub_type

杂志文章

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