Abstract:
OBJECTIVE:We present preliminary results of a new method (hereinafter called 'CT-clearance') to measure single kidney contrast media clearance by performing multiphasic helical CT of the kidneys. CT-clearance was calculated according to an extension of the Patlak-Plot. In contrast to prior investigators, who repeatedly measured a single slice, this method makes it possible to calculate single kidney clearance from at least three spiral CTs, utilizing the whole kidney volume. METHODS:Spiral CT of the kidneys was performed unenhanced and about 30 and 100 s after administration of about 120 ml iopromide. Sum-density of the whole kidneys and aortic density was calculated from this data. Using this data, renal clearance of contrast media was calculated by CT-clearance in 29 patients. As reference, Serum-clearance was calculated in 24 patients by application of a modified one-exponential slope model. Information on the relative kidney function was gained by renal scintigraphy with Tc99m-MAG-3 or Tc99m-DMSA in 29 patients. RESULTS:Linear regression analysis revealed a correlation coefficient of CT-clearance with Serum-clearance of r=0.78 with Cl (CT) [ml/min]=22.2+1.03 * Cl (serum), n=24. Linear regression of the relative kidney function (rkf) of the right kidney calculated by CT-clearance compared to scintigraphy results provided a correlation coefficient r=0.89 with rkf(CT)[%]=18.6+0.58 * rkf(scintigraphy), n=29. CONCLUSION:The obtained results of contrast media clearance measured by CT-clearance are in the physiological range of the parameter. Future studies should be performed to improve the methodology with the aim of higher accuracy. More specifically, better determination of the aortic density curve might improve the accuracy.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Hackstein N,Puille MF,Bak BH,Scharwat O,Rau WSdoi
10.1016/s0720-048x(01)00323-0keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
201-8issue
3eissn
0720-048Xissn
1872-7727pii
S0720-048X(01)00323-0journal_volume
39pub_type
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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更新日期:2009-11-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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