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Etiology of spontaneous pneumothorax in 105 HIV-infected patients without highly active antiretroviral therapy.

Abstract：

INTRODUCTION:Spontaneous pneumothorax (SP) is a frequent complication in non-treated HIV-infected patients as a complication of opportunistic infections and tumours. OBJECTIVE:To analyse the aetiology of SP in non-treated HIV patients. PATIENTS AND METHODS:Observational study of SP cases observed in a cohort of 9831 of non-treated HIV-infected patients attended in seven Spanish hospitals. RESULTS:105 patients (1.06%) developed SP. The aetiological cause was identified in 89 patients. The major causes identified were: bacterial pneumonia (36 subjects, 34.3%); Pneumocystis jiroveci pneumonia (PJP) (31 patients, 29.5%); and pulmonary tuberculosis (17 cases, 15.2%). The most common cause of SP in drugs users was bacterial pneumonia (40%), whereas PJP was more common (65%) in sexual transmitted HIV-patients. The most common cause of bilateral SP was PJP (62.5%) whereas unilateral SP was most commonly associated with bacterial pneumonia (40.2%). The most common cause of SP in patients with a CD4+ lymphocyte count >200 cells/ml and in patients without AIDS criteria was bacterial pneumonia. PJP was the more common cause in patients with a CD4+ lymphocyte count <200 cells/ml or with AIDS. CONCLUSION:The incidence of SP in non-treated HIV-infected patients was 1.06%. The aetiology was related to the patients risk practices and to their degree of immunosuppression. Bacterial pneumonia was the most common cause of SP.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Rivero A,Perez-Camacho I,Lozano F,Santos J,Camacho A,Serrano A,Cordero E,Jiménez F,Torres-Tortosa M,Torre-Cisneros J,Andalusian Group for the Study of Infectious Diseases (GAEI).

doi

10.1016/j.ejrad.2008.05.003

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

264-8

issue

2

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(08)00245-3

journal_volume

71

pub_type

杂志文章,多中心研究

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