当前位置： SCI文献检索 > EUROPEAN JOURNAL OF RADIOLOGY期刊下所有文献 > Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer.

Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer.

Abstract：

OBJECTIVES:The purpose of this study was to test whether dual functional gold nano-shelled microcapsules (GNS-MCs) can be used as an ultrasound imaging enhancer and as an optical absorber for photothermal therapy (PTT) in a rodent model of breast cancer. METHODS:GNS-MCs were fabricated with an inner air and outer gold nanoshell spherical structure. Photothermal cytotoxicity of GNS-MCs was tested with BT474 cancer cells in vitro and non-obese diabetes-SCID (NOD/SCID) mice with breast cancer. GNS-MCs were injected into the tumor under ultrasound guidance and treated with near-infrared (NIR) laser irradiation. The photothermal ablative effectiveness of GNS-MCs was evaluated by measuring the surface and internal temperature of the tumor as well as the size of the tumor using histological confirmation. RESULTS:NIR laser irradiation resulted in significant tumor cell death in GNS-MCs-treated BT474 cells in vitro. GNS-MCs were able to serve as an ultrasound enhancer to guide the intratumoral injection of GNS-MCs and ensure their uniform distribution. In vivo studies revealed that NIR laser irradiation increased the intratumoral temperature to nearly 70°C for 8 min in GNS-MCs-treated mice. Tumor volumes decreased gradually and tumors were completely ablated in 6 out of 7 mice treated with GNS-MCs and laser irradiation by 17 days after treatment. CONCLUSION:This study demonstrates that ultrasound-guided PTT with theranostic GNS-MCs is a promising technique for in situ treatment of breast cancer.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Wang S,Dai Z,Ke H,Qu E,Qi X,Zhang K,Wang J

doi

10.1016/j.ejrad.2013.09.010

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

117-22

issue

1

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(13)00508-1

journal_volume

83

pub_type

杂志文章

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