Abstract:
PURPOSE:To investigate associations between imaging features of tumors and age, gender and body mass index (BMI) in patients with renal cell carcinoma. METHOD:This IRB-approved, HIPAA-compliant study included 1348 patients with histopathologically confirmed renal cell carcinoma of the clear cell subtype (ccRCC, n = 904) or non-clear cell subtype (n = 444), who underwent pre-treatment CT imaging less than 180 days before nephrectomy between 1999 and 2011. Two radiologists independently, retrospectively analyzed all imaging studies and identified features (necrosis, renal vein invasion, contact with renal sinus fat, multicystic appearance and nodular enhancement), which were then correlated with patient age, gender and BMI at time of surgery. RESULTS:Inter-reader agreement on imaging features ranged from substantial to excellent (kappa: 0.688 to 0.982). In the ccRCC group, multicystic tumor appearance was significantly associated with lower patient age (p < 0.05) and lower BMI (p < 0.05); the presence of renal vein invasion was significantly associated with lower BMI in males (p < 0.05); and both tumor contact with the renal sinus and nodular enhancement were significantly associated with greater patient age (p < 0.05). In the non-clear cell RCC group, necrosis was associated with lower BMI for females (p < 0.05). CONCLUSIONS:This study demonstrated significant associations between imaging features of RCC and patient age and BMI, hinting an influence of these factors on tumor biology and genomic make-up. These findings could aid future studies in selecting patients while investigating genomic, molecular and metabolic variables in RCC and might potentially impact on future stratification and therapy of patients.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Hötker AM,Karlo CA,Di Paolo PL,Zheng J,Moskowitz CS,Russo P,Hricak H,Akin Odoi
10.1016/j.ejrad.2020.109096subject
Has Abstractpub_date
2020-08-01 00:00:00pages
109096eissn
0720-048Xissn
1872-7727pii
S0720-048X(20)30285-0journal_volume
129pub_type
杂志文章abstract::We report a case of giant, benign renal cyst that was treated with percutaneous aspiration and sclerotherapy using 95% alcohol. A seven French catheter was inserted into the cyst under ultrasonographic and fluoroscopic guidance, and was then left in place to drain the cyst contents. Approximately 4 l of fluid was drai...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(01)00280-7
更新日期:2001-10-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:European journal of radiology
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journal_title:European journal of radiology
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doi:10.1016/j.ejrad.2012.12.014
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journal_title:European journal of radiology
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abstract:PURPOSE:To compare projected breast area, image quality, pain experience and radiation dose between mammography performed with and without radiolucent positioning sheets. METHODS:184 women screened in the Dutch breast screening programme (May-June 2012) provided written informed consent to have one additional image ta...
journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2015.05.005
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(00)00189-3
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journal_title:European journal of radiology
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更新日期:2015-08-01 00:00:00
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journal_title:European journal of radiology
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doi:10.1016/j.ejrad.2009.09.025
更新日期:2010-07-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2007.09.018
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2007.02.001
更新日期:2007-09-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.01.029
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journal_title:European journal of radiology
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doi:
更新日期:1987-02-01 00:00:00
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journal_title:European journal of radiology
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更新日期:2012-08-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00