Renal cell carcinoma: Associations between tumor imaging features and epidemiological risk factors.

Abstract:

PURPOSE:To investigate associations between imaging features of tumors and age, gender and body mass index (BMI) in patients with renal cell carcinoma. METHOD:This IRB-approved, HIPAA-compliant study included 1348 patients with histopathologically confirmed renal cell carcinoma of the clear cell subtype (ccRCC, n = 904) or non-clear cell subtype (n = 444), who underwent pre-treatment CT imaging less than 180 days before nephrectomy between 1999 and 2011. Two radiologists independently, retrospectively analyzed all imaging studies and identified features (necrosis, renal vein invasion, contact with renal sinus fat, multicystic appearance and nodular enhancement), which were then correlated with patient age, gender and BMI at time of surgery. RESULTS:Inter-reader agreement on imaging features ranged from substantial to excellent (kappa: 0.688 to 0.982). In the ccRCC group, multicystic tumor appearance was significantly associated with lower patient age (p < 0.05) and lower BMI (p < 0.05); the presence of renal vein invasion was significantly associated with lower BMI in males (p < 0.05); and both tumor contact with the renal sinus and nodular enhancement were significantly associated with greater patient age (p < 0.05). In the non-clear cell RCC group, necrosis was associated with lower BMI for females (p < 0.05). CONCLUSIONS:This study demonstrated significant associations between imaging features of RCC and patient age and BMI, hinting an influence of these factors on tumor biology and genomic make-up. These findings could aid future studies in selecting patients while investigating genomic, molecular and metabolic variables in RCC and might potentially impact on future stratification and therapy of patients.

journal_name

Eur J Radiol

authors

Hötker AM,Karlo CA,Di Paolo PL,Zheng J,Moskowitz CS,Russo P,Hricak H,Akin O

doi

10.1016/j.ejrad.2020.109096

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

109096

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(20)30285-0

journal_volume

129

pub_type

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