Abstract:
PURPOSE:To compare diagnostic capability of preoperative N-staging of lung cancer between thin-section CT of the mediastinum and FDG PET, and 5mm slice thickness CT. MATERIALS AND METHODS:The subjects were 34 patients with lung carcinoma who were examined by both CT and PET, and subsequently underwent surgery between May 2005 and January 2007. CT was carried out with a 16 detector row helical CT scanner. The raw data were reconstructed into 5 mm slice thickness and 1mm slice thickness (thin-section CT). A total of 251 lymph node stations were retrospectively assessed for the presence of lymph node metastasis with thin-section CT, 5 mm CT and PET. In the interpretations of thin-section CT and 5 mm CT, we employed multi-criteria as follows: nodular calcification and intranodal fat as benign criteria, and short-axis diameter more than 10 mm (size criterion), focal low density other than fat, surrounding fat infiltration and convex margin in hilar lymph nodes, as malignant criteria. On PET, maximum standardized uptake value (SUVmax) of 2.5 or more was used as the criterion of malignancy. Sensitivity and specificity were compared between these examinations using McNemar test. RESULTS:Sensitivities and specificities of thin-section CT, 5 mm CT and PET were 25%, 25%, 25%, and 97%, 94%, 98%, respectively. The statistical analysis revealed that the specificity of 5 mm CT was significantly lower than those of thin-section CT (p=0.039) and PET (p=0.006), while no difference was present between thin-section CT and PET. CONCLUSION:Thin-section CT of the mediastinum using multiple criteria was comparable to PET in preoperative N-staging of lung cancer.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Nambu A,Kato S,Motosugi U,Araki T,Okuwaki H,Nishikawa K,Saito A,Matsumoto K,Ichikawa Tdoi
10.1016/j.ejrad.2009.01.021subject
Has Abstractpub_date
2010-03-01 00:00:00pages
510-7issue
3eissn
0720-048Xissn
1872-7727pii
S0720-048X(09)00020-5journal_volume
73pub_type
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