Abstract：
:Hypogonadism, resulting from iron-induced pituitary dysfunction, is the most frequently reported complication in patients with beta-thalassaemia major. The aim of this study was to evaluate pituitary Magnetic Resonance Imaging (MRI) signal intensity reduction, on T2*-weighted images, as a marker of pituitary iron overload. Thirty patients (13 females and 17 males, mean age: 16.6+/-4.1) with beta-thalassaemia major on conventional treatment and 13 healthy volunteers (7 females and 6 males, mean age: 11+/-4.51 years) were studied with T2*-weighted images of the anterior pituitary using a 1.5T unit. Four thalassaemic patients (2 females and 2 males) had clinical hypogonadism and required hormonal replacement treatment. Results revealed a statistically significant reduction of pituitary signal intensity in the thalassaemia group compared to controls (p<0.001). Moreover, hypogonadal patients had significantly decreased MRI values compared to thalassaemic patients without hypogonadism (p=0.017). Relatively decreased adeno-hypophyseal MRI signal intensity was recorded in pubertal thalassaemic patients. A significant negative correlation was observed between pituitary MRI values and age (r=-0.67, r(2)=0.443, p=0.001), whereas ferritin levels and pituitary MRI values were moderately correlated (r=-0.56, r(2)=0.32, p=0.08) in adult thalassaemic patients. In conclusion, pituitary MRI indices as measured on T2*-weighted images seem to reflect pituitary iron overload and could, therefore, be used for a preclinical detection of patients who are in greater danger of developing hypogonadism.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Christoforidis A,Haritandi A,Perifanis V,Tsatra I,Athanassiou-Metaxa M,Dimitriadis ASdoi
10.1016/j.ejrad.2006.11.016subject
Has Abstractpub_date
2007-04-01 00:00:00pages
138-42issue
1eissn
0720-048Xissn
1872-7727pii
S0720-048X(06)00484-0journal_volume
62pub_type
杂志文章abstract：:To evaluate the diagnostic ability of transrectal and transvaginal ultrasonography (TRUS and TVUS), 132 patients with rectal carcinoma were examined. Analysis of the data obtained has shown that the high quality of endosonographic imaging allows the performance of detailed staging of rectal carcinoma. In the great maj...
journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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更新日期：1981-03-01 00:00:00
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更新日期：2011-10-01 00:00:00
