Abstract:
PURPOSE:Currently, clinical research approaches are sparse in molecular imaging studies. Moreover, possible links between imaging features and pathological laboratory parameters are unknown, so far. Therefore, the goal was to find a possible relationship between imaging features and peripheral blood cell apoptosis, and thereby to present a novel way to complement molecular imaging research. MATERIALS AND METHODS:The investigation has been done in systemic lupus erythematosus (SLE), a prototype of an autoimmune disease characterized by multiorgan involvement, autoantibody production, and disturbed apoptosis. Retrospectively, radiological findings have been compared to both autoantibody findings and percentage apoptotic blood cells. RESULTS:Two SLE groups could be identified: patients with normal (annexin V binding<20%), and with increased apoptosis (annexin V binding>20%) of peripheral blood cells. The frequency of radiological examinations in SLE patients significantly correlated with an increased percentage of apoptotic cells (p<0.005). In patients with characteristic imaging findings (e.g. lymph node swelling, pleural effusion) an elevated percentage of apoptotic cells was present. In contrast SLE-patients with normal imaging findings or uncharacteristic results of minimal severity had normal percentages of apoptotic blood cells. CONCLUSION:This correlation between radiographic findings and percentage of apoptotic blood cells provides (1) further insight into pathological mechanisms of SLE, (2) will offer the possibility to introduce apoptotic biomarkers as molecular probes for clinical molecular imaging approaches in future to early diagnose organ complaints in patients with SLE, and (3) is a plea to complement molecular imaging research by this clinical approach.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Böhm Idoi
10.1016/j.ejrad.2010.08.030subject
Has Abstractpub_date
2011-09-01 00:00:00pages
365-8issue
3eissn
0720-048Xissn
1872-7727pii
S0720-048X(10)00406-7journal_volume
79pub_type
杂志文章abstract:PURPOSE:Within five years after presentation 50-60% of patients with chronic limb-threatening ischemia (CLI) have died or had an amputation. We assessed the predictive value of lower extremity arterial calcification on computed tomography (CT) characteristics on both 7-years amputation-free survival and 10-years all-ca...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109305
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To evaluate the influence of radiation dose settings and reconstruction algorithms on the measurement accuracy and reproducibility of semi-automated pulmonary nodule volumetry. MATERIALS AND METHODS:CT scans were performed on a chest phantom containing various nodules (10 and 12mm; +100, -630 and -800HU) at 12...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.01.025
更新日期:2014-05-01 00:00:00
abstract::Renal venous DSA yields diagnostically adequate results in an unselected population in more than 85% of cases. Image quality is compromised predominantly by inadequate contrast enhancement, motion artifacts from the stomach and the bowel, and obesity. The effect of these factors increases with patient age. Selection o...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract::Spinal tumors are uncommon lesions but may cause significant morbidity in terms of limb dysfunction. In establishing the differential diagnosis for a spinal lesion, location is the most important feature, but the clinical presentation and the patient's age and gender are also important. Magnetic resonance (MR) imaging...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2003.10.021
更新日期:2004-05-01 00:00:00
abstract:PURPOSE:To determine whether imaging parameters derived from intravoxel incoherent motion (IVIM) diffusion weighted imaging (DWI) vary according to tumor-stroma ratio(TSR) or dominant stroma type of breast cancer. METHODS:We prospectively enrolled 77 patients with breast cancer who underwent IVIM DWI on a 3.0 T MR sca...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2019.108686
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To evaluate image quality and radiation dose of single heartbeat 640-slice coronary CT angiography (CCTA) in patients with chronic Atrial Fibrillation (cAF) in comparison with subjects in normal sinus rhythm. METHODS:A cohort of 71 patients with cAF was matched with 71 subjects in normal sinus rhythm (NSR) ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.11.035
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:Fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) extent or FVH-DWI mismatch as a primary influencing factor of clinical outcome in acute ischemic stroke is controversial. This study elucidated the regional pathophysiology and tissue fate in four types of cortical territories classified ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109490
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:To investigate the feasibility of implementing quantitative T1-perfusion in the routine MRA-protocol and to obtain a first experience in normals and pathology. MATERIALS AND METHODS:For perfusion imaging, IR-prepared FLASH (one 4 mm slice at mid-renal level, TR 4.4 ms, TE 2.2 ms, TI 180 ms, FA 50 degrees , ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2007.11.033
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:The production of a copy of the fracture or a deformity in a bone with a complex geometry can be one of the important applications of the integration between two modern computer-based technologies, reverse engineering (RE) and rapid prototyping (RP). METHODS:This article reviews recent development in this f...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2010.10.007
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To assess the usefulness of amide proton transfer (APT) imaging in differentiating parotid tumors. MATERIAL AND METHODS:We retrospectively analyzed 43 histopathologically proven parotid solid tumors with diameters ≥2 cm. Twenty-one tumors were benign and 12 tumors were malignant. Two-dimensional APT imaging wa...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109047
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:To evaluate if size-based cut-offs based on MR imaging can successfully assess clinically significant prostate cancer (csPCA). The goal was to improve the currently applied size-based differentiation criterion in PI-RADS. METHODS AND MATERIALS:MRIs of 293 patients who had undergone 3 T MR imaging with subseque...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109071
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:Our aim was to determine whether inward or outward movement of the secretions in the paranasal sinuses due to nose blowing after nasal decongestion has any effect on the paranasal sinus computed tomography (CT) images in patients with sinusitis and to asses whether nose blowing may result in misdiagnosis or o...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2004.04.003
更新日期:2005-02-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of optimized T1-Perfusion MRI protocol (protocol-2) with whole brain coverage and improved spatial resolution using Compressed-SENSE (CSENSE) to differentiate high-grade-glioma (HGG) and low-grade-glioma (LGG) and to compare it with the conventional protocol (protocol-1) with partial br...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109049
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:To compare the diagnostic performances of digital breast tomosynthesis (DBT) and ultrasound for the dense breasts with category 0 at conventional digital mammography. MATERIALS AND METHODS:This retrospective study was approved by the institutional review board, and informed consent was waived. Among the 1103 p...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2015.09.026
更新日期:2016-01-01 00:00:00
abstract:AIM:The aim of the present study was to investigate the diagnostic and prognostic value of combined (18)F-2-fluorodeoxyglucose positron emission tomography and contrast enhanced X-ray computed tomography (FDG-PET/CT) in women with a suspicion of recurrent ovarian cancer. PATIENTS AND METHODS:We retrospectively reviewe...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2013.12.006
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To determine the diagnostic performance of the "central echogenic area" sonographic finding in differentiating papillary carcinomas from benign nodules and to how this finding may be used to improve fine needle aspiration(FNA) technique/utilization. MATERIALS AND METHODS:We retrospectively analyzed ultrasound ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2018.01.029
更新日期:2018-04-01 00:00:00
abstract::Screening (early detection of disease in asymptomatic groups of persons) with whole-body MR (wb-MR) has only recently become possible. Technical requirements include extended scanner table range and extended coverage with surface coils. This allows for examining the whole body without repositioning the patient. wb-MR ...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2009.02.011
更新日期:2009-06-01 00:00:00
abstract::Colon interposition was carried out in 12 patients with oesophageal carcinoma and on 38 patients with benign oesophageal disease an average of 71 months before the radiographic examination. Various ischaemic changes including "jejunization", loss of haustration and stricture formation were observed in 15 cases. In 12 ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
abstract:PURPOSE:To evaluate two different iodine concentrations of contrast material for detecting hypervascular hepatocellular carcinomas (HCCs) in cirrhotic liver by multi-detector row helical CT (MDCT) when a fixed contrast material volume and injection rate is used. MATERIALS AND METHODS:Institutional Review Board approva...
journal_title:European journal of radiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejrad.2010.10.006
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:This study assesses the rate of enhancement of breast fibroglandular tissue after administration of a magnetic resonance imaging (MRI) gadolinium-based contrast agent and determines its relationship with response to neoadjuvant therapy (NAT) in women with breast cancer. METHOD:Women with locally advanced breas...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2021.109534
更新日期:2021-01-09 00:00:00
abstract:OBJECTIVES:To compare the assessment of global and regional left ventricular (LV) function using 64-slice multislice computed tomography (MSCT), 2D echocardiography (2DE) and cardiac magnetic resonance (CMR). METHODS:Thirty-two consecutive patients (mean age, 56.5+/-9.7 years) referred for evaluation of coronary arter...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2007.03.008
更新日期:2008-01-01 00:00:00
abstract::The objective of this study was to assess the clinical value of pelvimetry to predict dystocia due to cephalopelvic disproportion. 63 patients who had received an abdominal CT scan postpartum were included. Pelvimetry was performed retrospectively with these datasets on a 3D workstation; there were no CT examinations ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2009.04.042
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to test whether dual functional gold nano-shelled microcapsules (GNS-MCs) can be used as an ultrasound imaging enhancer and as an optical absorber for photothermal therapy (PTT) in a rodent model of breast cancer. METHODS:GNS-MCs were fabricated with an inner air and outer gold...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2013.09.010
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Run-off Computed Tomography Angiography (run-off CTA) of the lower extremities has become the method of choice for the diagnostic imaging of patients suffering from peripheral arterial disease (PAD). However, it remains a challenging radiological examination with a considerable risk of non-diagnostic image qual...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2018.11.030
更新日期:2019-01-01 00:00:00
abstract::The physics of bubbles and of their oscillations is extremely complex and attempts at its mathematical description are generally inaccessible. Yet some idea, in broad descriptive terms at least, is very helpful in understanding bubble phenomena of clinical interest. A brief attempt to provide such a description is giv...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(02)00023-2
更新日期:2002-03-01 00:00:00
abstract::A technique for the biopsy of abdominal masses consisting of the simultaneous insertion of multiple needles is described. This technique was employed in 45 patients. The results were compared with the author's preceding experience with 32 cases performed with a conventional technique of sequential biopsies. Adequate s...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::Radiation exposure from conventional fluoroscopy and from video disc recording was estimated during routine nailing of hip fractures. Mean fluoroscopic time with conventional fluoroscopy was 385 +/- 168 s. and with video disc recording 24 +/- 9 s. The time required for the X-ray system to form one television image, as...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract::Adrenal cortical tumours are uncommon in children. For many years it was thought that the majority were malignant with a poor prognosis. Pathological criteria for malignancy are unreliable for these tumours in childhood. The radiological findings in seven children are presented. Large tumour size (> 6 cm diameter) and...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/0720-048x(94)90334-4
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVES:To investigate whether a dose reduction of Gadobutrol for renal magnetic resonance angiography (MRA) at 7 Tesla (T) is feasible while preserving diagnostic image quality. METHODS:Ten healthy volunteers were enrolled for a renal MRA on a 7T scanner. Fast low angle shot (FLASH) MRA data sets were obtained uti...
journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ejrad.2016.11.007
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To assess the role of apparent diffusion coefficient (ADC) measured with diffusion-weighted imaging (DWI) in predicting and assessing response of hepatocellular carcinoma (HCC) to transarterial chemoembolization (TACE). METHODS:Thirty-six patients with cirrhosis and untreated HCC who underwent TACE and MRI w...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2012.11.026
更新日期:2013-04-01 00:00:00