Evaluation of incidentally discovered adrenal masses with PET and PET/CT.

Abstract:

BACKGROUND AND PURPOSE:Incidentally discovered adrenal masses are commonly seen with high resolution diagnostic imaging performed for indications other than adrenal disease. Although the majority of these masses are benign and non-secretory, their unexpected discovery prompts further biochemical and often repeated imaging evaluations, sufficient to identify hormonally active adrenal masses and/or primary or metastatic neoplasms to the adrenal(s). In the present paper we investigate the role of PET and PET/CT for the detection of adrenal incidentalomas in comparison with CT and MRI. MATERIALS AND METHODS:a systematic revision of the papers published in PubMed/Medline until September 2010 was done. RESULTS:The diagnostic imaging approach to incidentally discovered adrenal masses includes computed tomography (CT), magnetic resonance imaging (MRI) and more recently positron emission tomography (PET) with radiopharmaceuticals designed to exploit mechanisms of cellular metabolism, adrenal substrate precursor uptake, or receptor binding. CONCLUSION:The functional maps created by PET imaging agents and the anatomic information provided by near-simultaneously acquired, co-registered CT facilitates localization and diagnosis of adrenal dysfunction, distinguishes unilateral from bilateral disease, and aids in characterizing malignant primary and metastatic adrenal disease.

journal_name

Eur J Radiol

authors

Wong KK,Arabi M,Bou-Assaly W,Marzola MC,Rubello D,Gross MD

doi

10.1016/j.ejrad.2010.12.060

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

441-50

issue

3

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(11)00009-X

journal_volume

81

pub_type

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