Monitoring of liver glycogen synthesis in diabetic patients using carbon-13 MR spectroscopy.


:To investigate the relationship between liver glucose, glycogen, and plasma glucose in diabetic patients, in vivo liver carbon-13 magnetic resonance spectroscopy ((13)C MRS) with a clinical 3.0T MR system was performed. Subjects were healthy male volunteers (n=5) and male type-2 diabetic patients (n=5). Pre- and during oral glucose tolerance tests (OGTT), (13)C MR spectra without proton decoupling were acquired in a monitoring period of over 6h, and in total seven spectra were obtained from each subject. For OGTT, 75g of glucose, including 5g of [1-(13)C]glucose, was administered. The MR signals of liver [1-(13)C]glucose and glycogen were detected and their time-course changes were assessed in comparison with the plasma data obtained at screening. The correlations between the fasting plasma glucose level and liver glycogen/glucose rate (Spearman: rho=-0.68, p<0.05, n=10) and the fasting plasma glucose level and liver glycogen peak/fasting rate (Spearman: rho=-0.67, p<0.05, n=10) indicated that (13)C MRS can perform noninvasive measurement of glycogen storage/degradation ability in the liver individually and can assist in tailor-made therapy for diabetes. In conclusion, (13)C MRS has a potential to become a powerful tool in diagnosing diabetes multilaterally.


Eur J Radiol


Tomiyasu M,Obata T,Nishi Y,Nakamoto H,Nonaka H,Takayama Y,Autio J,Ikehira H,Kanno I




Has Abstract


2010-02-01 00:00:00














  • Clinical utility of real-time ultrasound-multimodality fusion guidance for percutaneous biopsy of focal liver lesions.

    abstract:OBJECTIVES:To prospectively evaluate the clinical value of real-time ultrasonography (US)-computed tomography (CT)/magnetic resonance imaging (MRI) fusion imaging for percutaneous needle biopsy of focal liver lesions (FLLs), and to compare its biopsy success rate with that of conventional US-guided biopsy in a propensi...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Ahn SJ,Lee JM,Chang W,Lee SM,Kang HJ,Yang HK,Han JK

    更新日期:2018-06-01 00:00:00

  • Magnetic resonance imaging of breast vascularity in medial versus lateral breast cancer.

    abstract:OBJECTIVE:Breasts with malignant tumors can demonstrate a general increased vascularity compared to the contralateral breast and a prominent blood vessel adjacent to the tumor on magnetic resonance imaging (MRI). The aim of the study was to further characterize these alterations in blood supply by location of the tumor...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Grubstein A,Yepes M,Kiszonas R

    更新日期:2010-08-01 00:00:00

  • Potential of ultrasound in the pediatric chest.

    abstract::Ultrasound (US) of chest, even with inherent limitations of the US beam and air, has been useful in many pediatric chest conditions. It has extended its role and is now widely used by many subspecialists in medicine. This review article will cover techniques, indications, and applications of chest US in neonates, infa...

    journal_title:European journal of radiology

    pub_type: 杂志文章,评审


    authors: Trinavarat P,Riccabona M

    更新日期:2014-09-01 00:00:00

  • Accuracy and consequences of 3D-fluoroscopy in upper and lower extremity fracture treatment: a systematic review.

    abstract:OBJECTIVES:The aim of this systematic review was to compare the diagnostic accuracy, subjective image quality and clinical consequences of 3D-fluoroscopy with standard imaging modalities (2D-fluoroscopy, X-ray or CT) during reduction and fixation of intra-articular upper and lower extremity fractures. METHODS:A system...

    journal_title:European journal of radiology

    pub_type: 杂志文章,meta分析,评审


    authors: Beerekamp MS,Sulkers GS,Ubbink DT,Maas M,Schep NW,Goslings JC

    更新日期:2012-12-01 00:00:00

  • CT and MR imaging of the normal and pathologic conditions of the facial nerve.

    abstract::Computed tomography (CT) and magnetic resonance imaging (MRI) are well established imaging modalities to examine the facial nerve as well as the course of the facial nerve itself. High spatial resolution is guaranteed not only in the x- and y-axis, but also in the z-axis using multislice spiral CT. With this technique...

    journal_title:European journal of radiology

    pub_type: 杂志文章,评审


    authors: Jäger L,Reiser M

    更新日期:2001-11-01 00:00:00

  • Clinical value of Doppler ultrasound in the first two months after kidney transplant.

    abstract::The ability of PI measurements to differentiate between acute rejection and ATN was investigated in 37 patients, who were frequently examined by duplex Doppler after kidney transplant. Absolute PI values as well as increase in PI were recorded and the clinical course was correlated with these pulsatility measurements....

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: van Leeuwen MS,Hené RJ,Muller AF,Beek FJ,Meyer R,Ganpat R

    更新日期:1992-01-01 00:00:00

  • Assessment and quantification of sources of variability in breast apparent diffusion coefficient (ADC) measurements at diffusion weighted imaging.

    abstract:PURPOSE:Apparent Diffusion Coefficient (ADC) measurements are increasingly used for assessing breast cancer response to neoadjuvant chemotherapy although little data exists on ADC measurement reproducibility. The purpose of this work was to investigate and characterise the magnitude of errors in ADC measures that may b...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Giannotti E,Waugh S,Priba L,Davis Z,Crowe E,Vinnicombe S

    更新日期:2015-09-01 00:00:00

  • Effects of reconstruction technique on the quality of abdominal CT angiography: A comparison between forward projected model-based iterative reconstruction solution (FIRST) and conventional reconstruction methods.

    abstract:PURPOSE:This study aimed to compare the quality of abdominal CT angiography (CTA) images obtained using conventional reconstruction algorithms with those obtained using a novel iterative algorithm (forward projected model-based iterative reconstruction solution, FIRST) for evaluating arteries in the abdomen. MATERIALS...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Wu R,Hori M,Onishi H,Nakamoto A,Fukui H,Ota T,Nishida T,Enchi Y,Satoh K,Tomiyama N

    更新日期:2018-09-01 00:00:00

  • Smartphones, tablets and mobile applications for radiology.

    abstract:BACKGROUND:Smartphones are phone devices that may also be used for browsing, navigation and running smaller computer programs called applications. One may consider them as compact personal computers which are primarily to be used for making phone calls. Tablets or "tablet PCs" are fully functioning standalone computers...

    journal_title:European journal of radiology

    pub_type: 杂志文章,评审


    authors: Székely A,Talanow R,Bágyi P

    更新日期:2013-05-01 00:00:00

  • Reject analysis: a pilot programme for image quality management.

    abstract::The radiographic film wastage and the different parameters affecting this wastage were analysed for a 9-week period at a 600-bed University Hospital. An overall reject rate of 7.6% was found. The different reasons for rejection were evaluated, while retake rate, relation between working experience of the personnel, am...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Arvanitis TN,Parizel PM,Degryse HR,De Schepper AM

    更新日期:1991-05-01 00:00:00

  • Evaluating feasibility of high resolution T1-perfusion MRI with whole brain coverage using compressed SENSE: Application to glioma grading.

    abstract:PURPOSE:To evaluate the efficacy of optimized T1-Perfusion MRI protocol (protocol-2) with whole brain coverage and improved spatial resolution using Compressed-SENSE (CSENSE) to differentiate high-grade-glioma (HGG) and low-grade-glioma (LGG) and to compare it with the conventional protocol (protocol-1) with partial br...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Sasi S D,Ramaniharan AK,Bhattacharjee R,Gupta RK,Saha I,Van Cauteren M,Shah T,Gopalakrishnan K,Gupta A,Singh A

    更新日期:2020-08-01 00:00:00

  • Whole-brain CT perfusion on admission predicts delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage.

    abstract:PURPOSE:The aim of this study is to prospectively evaluate whole-brain CT perfusion (CTP) on admission to predict delayed cerebral ischemia (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH). METHODS:All 252 consecutive patients with aSAH enrolled in this study underwent one-stop whole-brain CTP scan wit...

    journal_title:European journal of radiology

    pub_type: 临床试验,杂志文章


    authors: Dong L,Zhou Y,Wang M,Yang C,Yuan Q,Fang X

    更新日期:2019-07-01 00:00:00

  • Reproducibility--an important factor determining the quality of computer-aided detection (CAD) systems.

    abstract:PURPOSE:To test the reproducibility of markings on mammography films set by a commercial computer aided detection (CAD) system. PATIENTS AND METHODS:One hundred unilateral mammography examinations (each in CC and MLO) of 100 patients with mammographically detected suspicious foci, which were histopathologically proven...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Malich A,Azhari T,Böhm T,Fleck M,Kaiser WA

    更新日期:2000-12-01 00:00:00

  • Association between esophageal dysmotility and gastroesophaeal reflux on barium studies.

    abstract:OBJECTIVE:To determine whether there is an association between abnormal primary peristalsis in the esophagus and gastroesophageal reflux (GER) on barium studies. METHODS:A computerized search of radiologic reports revealed 151 patients with esophageal dysmotility (characterized by intermittently decreased or absent pe...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Campbell C,Levine MS,Rubesin SE,Laufer I,Redfern G,Katzka DA

    更新日期:2006-07-01 00:00:00

  • Blood flow parameters in the short gastric vein and splenic vein on Doppler ultrasound reflect gastric variceal bleeding.

    abstract:PURPOSE:Hemodynamic features associated with the bleeding from gastric fundal varices (FV) have not been fully examined. The purpose of this study was to elucidate hemodynamics in the short gastric vein (SGV) which is a major inflow route for FV and flow direction of the splenic vein (SV) in relation to bleeding FV. M...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Maruyama H,Ishihara T,Ishii H,Tsuyuguchi T,Yoshikawa M,Matsutani S,Yokosuka O

    更新日期:2010-07-01 00:00:00

  • Panoramic zonography in evaluation of recurrent basal cell carcinoma of the face.

    abstract::Nine patients with recurrent, facial basal cell carcinoma were followed up both clinically and radiographically using a panoramic technique. A cylindrical image track was used for panoramic radiography. Five patients had bony destruction due to tumour re-occurrence, four patients had bony defects caused by surgery. Th...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Hallikainen D,Tötterman S,Asko-Seljavaara S,Paukku P

    更新日期:1984-11-01 00:00:00

  • Optimal sequence timing of CT angiography and perfusion CT in patients with stroke.

    abstract:OBJECTIVE:Standard stroke CT protocols start with non-enhanced CT followed by perfusion-CT (PCT) and end with CTA. We aimed to evaluate the influence of the sequence of PCT and CTA on quantitative perfusion parameters, venous contrast enhancement and examination time to save critical time in the therapeutic window in s...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Morhard D,Wirth CD,Reiser MF,Schulte-Altedorneburg G,Ertl-Wagner B

    更新日期:2013-06-01 00:00:00

  • Contrast-enhanced ultrasound study of primary hepatic angiosarcoma: a pitfall of non-enhancement.

    abstract:OBJECTIVE:To investigate the contrast-enhanced ultrasound (CEUS) characteristics of primary hepatic angiosarcoma (PHA). METHODS:The sonographic findings and CEUS images of PHA in three patients were retrospectively analyzed. RESULTS:In our study, 3 cases of PHA (2 multiple nodules and 1 solitary mass) showed similar ...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Wang L,Lv K,Chang XY,Xia Y,Yang ZY,Jiang YX,Dai Q,Tan L,Li JC

    更新日期:2012-09-01 00:00:00

  • Angiographic properties of Gd-DTPA-24-cascade-polymer--a new macromolecular MR contrast agent.

    abstract:PURPOSE:A new macromolecular MR contrast agent, Gd-DTPA-24-cascade-polymer, was assessed for MR angiography of peritumoral vessels in rats. MATERIAL AND METHODS:High resolution 3D-SPGR (TR/TE 100/5ms, alpha = 90 degrees) angiograms were acquired in 10 Fischer rats bearing subcutaneous R3230 mammary adenocarcinomas. MR...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Schwickert HC,Roberts TP,Mühler A,Stiskal M,Demsar F,Brasch RC

    更新日期:1995-07-01 00:00:00

  • Gastric gastrointestinal stromal tumours (2-5 cm): Correlation of CT features with malignancy and differential diagnosis.

    abstract:PURPOSE:The purpose of this study was to investigate the computed tomography (CT) features of 2-5 cm gastric gastrointestinal stromal tumors (GISTs), schwannomas and leimyomas which have close relationship with malignancy evaluation and differential diagnosis. METHOD:Seventy-six patients with pathologically confirmed ...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Chen Z,Yang J,Sun J,Wang P

    更新日期:2020-02-01 00:00:00

  • Predictors of severity in ischemic colitis: Usefulness of early ultrasonography.

    abstract:PURPOSE:The main objective was to evaluate the usefulness of early ultrasonography for determining prognosis of patients with ischemic colitis. MATERIALS AND METHODS:We reviewed the histories of patients with diagnosis of ischemic colitis over a period of 11 years. Two hundred twenty nine patients with ischemic coliti...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Pastor-Juan MDR,Ripollés T,Martí-Bonmatí L,Martínez MJ,Simó L,Gómez D,Revert R

    更新日期:2017-11-01 00:00:00

  • Pancreaticobiliary involvement in treated type 1 autoimmune pancreatitis: Imaging pattern and risk factors for disease relapse.

    abstract:PURPOSE:To evaluate the imaging pattern of pancreaticobiliary lesions in patients with treated type 1AIP, to determine the incidence of disease relapse and malignancy, and to identify the risk factors. METHOD:The institutional review board approval was acquired. All patients gave written informed consent. From a prosp...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Zhu L,Xue HD,Zhang W,Wang Q,Tan B,Lai YM,Zheng WY,Asbach P,Hamm B,Denecke T,Jin ZY

    更新日期:2019-11-01 00:00:00

  • Detection of biliary and vascular anatomy in living liver donors: value of gadobenate dimeglumine enhanced MR and MDCT angiography.

    abstract:OBJECTIVE:To evaluate the performance of magnetic resonance (MR) and multidetector computed tomography (MDCT) in the assessment of living donor's vascular and biliary anatomy, having surgical findings as reference standard. METHODS:Thirty-two living liver donors underwent MR cholangiography (1.5-T; standard cholangiog...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Artioli D,Tagliabue M,Aseni P,Sironi S,Vanzulli A

    更新日期:2010-11-01 00:00:00

  • Radiation protection of patients in diagnostic radiology: status of practice in five Eastern-European countries, based on IAEA project.

    abstract::The purpose of this work was to investigate status of imaging technology and practice in five countries in Eastern-European region and evaluate the impact of IAEA projects on radiation protection of patients. Information collected using standardized IAEA protocol included status of technology, practices and patient do...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Ciraj-Bjelac O,Beganovic A,Faj D,Gershan V,Ivanovic S,Videnovic IR,Rehani MM

    更新日期:2011-08-01 00:00:00

  • The clinical value of antiplatelet therapy for patients with hemorrhage after thrombolysis based on susceptibility-weighted imaging: a prospective pilot study.

    abstract:PURPOSE:To evaluate treatment decision-making based on susceptibility-weighted imaging (SWI) in patients with hemorrhage after thrombolysis. MATERIALS AND METHODS:One hundred and forty-six patients without intracranial hemorrhage on CT after receiving recombinant tissue plasminogen activator (rt-PA) were allocated to ...

    journal_title:European journal of radiology

    pub_type: 杂志文章,随机对照试验


    authors: Lu J,Li YH,Li YD,Li MH,Zhao JG,Chen SW

    更新日期:2012-12-01 00:00:00

  • Fulminant hepatic failure in children: etiology, histopathology and MDCT findings.

    abstract:INTRODUCTION:The purpose of this study is to determine the etiologies, histopathology and MDCT findings of children with fulminant hepatic failure admitted to our institution. MATERIALS AND METHODS:Between June 2004 and November 2006, 15 children with fulminant hepatic failure who underwent MDCT were included retrospe...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Cakir B,Kirbas I,Demirhan B,Tarhan NC,Bozkurt A,Ozcay F,Coskun M

    更新日期:2009-11-01 00:00:00

  • Complications of percutaneous stereotactic vacuum assisted breast biopsy system utilizing radio frequency.

    abstract:OBJECTIVE:The Breast Lesion Excision System (BLES) is a novel, automatic breast biopsy device that utilizes radiofrequency to excise suspicious non-palpable mammographic lesions. The purpose of the present prospective study is to report and evaluate the complications of this new technique. MATERIALS AND METHODS:In a t...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Al-Harethee W,Theodoropoulos G,Filippakis GM,Papapanagiotou I,Matiatou M,Georgiou G,Kalles V,Koulocheri D,Nonni A,Konstadoulakis MM,Manouras A,Zografos GC

    更新日期:2013-04-01 00:00:00

  • Thrombocytopenic thrombotic purpura: severe clinic with no CT, minor MRI, but a SPECT correlate.

    abstract::A 28-year-old woman with primarily therapy refractory TTP was followed neuroradiologically over 6 months. Despite pronounced neurological and neuropsychiatric symptoms including hemiparesis and aphasia she had unremarkable CT scans on two occasions. Three MRI exams showed no correlate for her neurological symptoms exc...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Baron Y,Bargemann T,Harten P,Gutschmidt HJ

    更新日期:1999-07-01 00:00:00

  • Usefulness of perfusion weighted magnetic resonance imaging with signal-intensity curves analysis in the differential diagnosis of sellar and parasellar tumors: preliminary report.

    abstract:PURPOSE:The most common pituitary tumors are adenomas, which however may be mimicked by other tumors that can show a very similar appearance in plain MRI. The aim of our study was to evaluate the usefulness of perfusion weighted MR imaging (PWI), including signal-intensity curves analysis in the differential diagnosis ...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Bladowska J,Zimny A,Guziński M,Hałoń A,Tabakow P,Czyż M,Czapiga B,Jarmundowicz W,Sąsiadek MJ

    更新日期:2013-08-01 00:00:00

  • Diffusion-weighted imaging properties of uterine fibroids pre- and post-uterine fibroid embolisation.

    abstract:OBJECTIVE:To determine the change in apparent diffusion coefficient (ADC) of uterine fibroids following uterine fibroid embolisation (UFE), and if the ADC change correlates with either volume loss or degree of contrast enhancement post-UFE. MATERIALS AND METHODS:This study was approved by our institutional review boar...

    journal_title:European journal of radiology

    pub_type: 杂志文章


    authors: Kirpalani A,Chong J,Yang N,Jenkins SJ,Nisenbaum R,Prabhudesai V,Anthwal S,Colak E

    更新日期:2014-09-01 00:00:00