Abstract:
:To investigate the relationship between liver glucose, glycogen, and plasma glucose in diabetic patients, in vivo liver carbon-13 magnetic resonance spectroscopy ((13)C MRS) with a clinical 3.0T MR system was performed. Subjects were healthy male volunteers (n=5) and male type-2 diabetic patients (n=5). Pre- and during oral glucose tolerance tests (OGTT), (13)C MR spectra without proton decoupling were acquired in a monitoring period of over 6h, and in total seven spectra were obtained from each subject. For OGTT, 75g of glucose, including 5g of [1-(13)C]glucose, was administered. The MR signals of liver [1-(13)C]glucose and glycogen were detected and their time-course changes were assessed in comparison with the plasma data obtained at screening. The correlations between the fasting plasma glucose level and liver glycogen/glucose rate (Spearman: rho=-0.68, p<0.05, n=10) and the fasting plasma glucose level and liver glycogen peak/fasting rate (Spearman: rho=-0.67, p<0.05, n=10) indicated that (13)C MRS can perform noninvasive measurement of glycogen storage/degradation ability in the liver individually and can assist in tailor-made therapy for diabetes. In conclusion, (13)C MRS has a potential to become a powerful tool in diagnosing diabetes multilaterally.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Tomiyasu M,Obata T,Nishi Y,Nakamoto H,Nonaka H,Takayama Y,Autio J,Ikehira H,Kanno Idoi
10.1016/j.ejrad.2008.10.019subject
Has Abstractpub_date
2010-02-01 00:00:00pages
300-4issue
2eissn
0720-048Xissn
1872-7727pii
S0720-048X(08)00573-1journal_volume
73pub_type
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
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journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
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