Abstract:
PURPOSE:To assess the safety and tolerability of transarterial drug-eluting bead chemoembolisation (DEB-TACE) using tightly calibrated 100-μm microspheres in hepatocellular carcinoma (HCC). METHOD:This multicentre prospective study included 131 patients with a 2-year follow-up. All patients had Child-Pugh scores ≤ B7, a good performance status, and Barcelona Clinic Liver Cancer stage A or B. Beads were loaded with 50 mg of doxorubicin per millilitre. Overall, 223 nodules were treated (mean size: 27.6 mm, average number of nodules per patient: 1.7). Toxicity was assessed using Common Terminology Criteria for Adverse Events 4.03 and response according to the modified Response Evaluation Criteria in Solid Tumours. The primary endpoint was safety. Secondary endpoints included technical success, post-embolisation syndrome (PES), local tumour response, and 2-year survival. RESULTS:A total of 214 DEB-TACE procedures were performed (mean per patient: 1.64), with a technical success rate of 97.6 % and a PES rate of 9.3 %. Major complications occurred in 6.8 % of patients and 4.1 % of procedures. There were no treatment-related deaths. Doxorubicin dose was an independent predictor of complications (p = 0.01). Four patients were lost to follow-up and 18 received liver transplants. Objective response rates were 74.6 %, 45.7 %, and 44.1 % at 6, 12, and 24 months, respectively. The cumulative 24-month overall survival rate was 55.96 %. Median survival was 22 months (interquartile range = 13-24). Co-morbidities and tumour response were independent predictors of survival (p = 0.0012 and 0.0052, respectively). Complications did not affect survival (p = 0.24). CONCLUSIONS:DEB-TACE with tightly calibrated 100-μm beads is safe and not associated with increases in biliary toxicity or complications. Tumour response and survival are in the expected range for chemoembolisation therapy. (Clinical trials ID: NCT02670122).
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Urbano J,Echevarria-Uraga JJ,Ciampi-Dopazo JJ,Sánchez-Corral JA,Cobos Alonso J,Anton-Ladislao A,Peña-Baranda B,Nacarino-Mejias V,González-Costero R,Muñoz Ruiz-Canela JJ,Pérez-Cuesta J,Lanciego C,de Gregorio MAdoi
10.1016/j.ejrad.2020.108966subject
Has Abstractpub_date
2020-05-01 00:00:00pages
108966eissn
0720-048Xissn
1872-7727pii
S0720-048X(20)30155-8journal_volume
126pub_type
杂志文章,多中心研究abstract:OBJECTIVES:To investigate whether a dose reduction of Gadobutrol for renal magnetic resonance angiography (MRA) at 7 Tesla (T) is feasible while preserving diagnostic image quality. METHODS:Ten healthy volunteers were enrolled for a renal MRA on a 7T scanner. Fast low angle shot (FLASH) MRA data sets were obtained uti...
journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ejrad.2016.11.007
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The management of community-acquired pneumonia (CAP) depends, in part, on the identification of the causative agents. The objective of this study was to determine the potential of thin-section computed tomography (CT) in differentiating bacterial and non-bacterial pneumonia. PATIENTS AND METHO...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2008.08.004
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:To compare the quantitative and subjective image quality in abdominal angiography between dual-energy CT (DECT) at the routine concentration of iodinated contrast agent (300mg/mL) and conventional 120-kVp single-energy CT (SECT) at the high concentration of contrast agent (370mg/mL). MATERIALS AND METHODS:Abdo...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.11.025
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Management of congenital pulmonary vein stenosis is a diagnostic challenge. Echocardiography may be insufficient and thus cardiac catheterization remains the reference standard in this setting. The aim of the study was to investigate the accuracy of cardiac-non-gated CT using 64-slice technology in detecting...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2008.02.006
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:To report our experience with transarterial glue embolization of the bronchial artery for life-threatening hemoptysis. MATERIALS AND METHODS:Twenty-five patients underwent bronchial artery embolization, using coaxial microcatheter technique, with a liquid agent, n-butyl-2-cyanoacrylate (NBCA), named glue, f...
journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ejrad.2008.10.017
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:To compare projected breast area, image quality, pain experience and radiation dose between mammography performed with and without radiolucent positioning sheets. METHODS:184 women screened in the Dutch breast screening programme (May-June 2012) provided written informed consent to have one additional image ta...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2015.07.005
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:To evaluate the early enhancement of coronary atherosclerotic plaque using contrast-enhanced MR angiography (CE-MRA) and investigate the association between unstable angina pectoris (UAP) and early enhancement of the plaque. METHODS:Forty-one patients presenting with angina pectoris and demonstrating single-ve...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2010.07.020
更新日期:2011-10-01 00:00:00
abstract::Eight patients with proven pulmonary sarcoidosis were investigated prospectively by computed tomography (CT) to determine beyond that obtained from conventional chest films. Although CT disclosed minor pulmonary "sarcoid nodules" not seen on the chest films, this did not influence the treatment. We conclude that CT wi...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVES:We aimed to study the ability of contrast enhanced MRI at 1.5 T and 11C-acetate PET/CT, both individually and using fused data, to detect localized prostate cancer. METHODS:Thirty-six men with untreated prostate cancer and negative for metastatic disease on pelvic CT and bone scan were prospectively enrolle...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.12.043
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To evaluate the image quality of early postoperative CT angiography with low contrast material and radiation dose using model-based iterative reconstruction (FIRST) for screening pseudoaneurysms after partial nephrectomy. METHODS:CT angiography was obtained before surgery using conventional iterative dose redu...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.108853
更新日期:2020-03-01 00:00:00
abstract::A group of 26 patients with carcinoma of the head and neck region was treated by superselective intra-arterial infusion of cisplatin (CDDP)-carboplatin (CBDCA). The tumor locations included the tongue (n = 4), oral base (n = 2), nasopharynx (n = 2), oropharynx (n = 8), hypopharynx (n = 4) and larynx (n = 4). Using the...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/0720-048x(95)00692-j
更新日期:1995-12-15 00:00:00
abstract:PURPOSE:To validate abdominal ultrasonography and helical computed tomography in detecting causes for sepsis in patients after abdominal surgery and to determine improved criteria for its use. MATERIALS AND METHODS:Eighty-five consecutive surgical patients primarily operated for non-infectious disease were included in...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2004.08.004
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:Currently, clinical research approaches are sparse in molecular imaging studies. Moreover, possible links between imaging features and pathological laboratory parameters are unknown, so far. Therefore, the goal was to find a possible relationship between imaging features and peripheral blood cell apoptosis, and...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2010.08.030
更新日期:2011-09-01 00:00:00
abstract::Digital 'conventional-like' (C-L) and edge-enhanced (E-E) posteroanterior chest roentgenograms of 42 healthy individuals were ranked twice (interval of at least 5 days) in the order of increasing lung parenchymal markings (a total of four rankings). This was done by three radiologists, two residents, one medical stude...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/0720-048x(94)90275-5
更新日期:1994-05-01 00:00:00
abstract:PURPOSE:The purpose of this study is to find out the prevalence, appearance and clinical symptoms of myocardial bridging (MB) by MDCT coronary angiography (CTA). MATERIALS AND METHODS:A total of 280 (50 females) consecutive patients followed with coronary artery disease or postoperative stent and bypass control, under...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2007.09.038
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:CT is considered the non-invasive gold standard for evaluating cardiac implantable electronic devices (CIEDs) lead perforation, but metal artifacts caused by the lead tip affect the image quality and make a definitive diagnosis challenging. We compared the performances of the metal artifact reduction (MAR) algo...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2021.109530
更新日期:2021-01-09 00:00:00
abstract::During cardiac angiography, hemodynamic alterations and surface electrocardiographic changes are common, predictable and dose-related adverse reactions to radiocontrast media. High osmolality, inadequate sodium content and local transient hypocalcemia are thought to be the main mechanisms responsible for these untowar...
journal_title:European journal of radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0720-048x(94)90095-7
更新日期:1994-05-01 00:00:00
abstract::Rapid advancements in multidetector row computed tomography (MDCT) are beginning to revolutionise cardiac imaging applications. As a consequence, coronary CT angiography (CTA) is fast emerging as a highly effective, noninvasive imaging technique for the assessment of coronary artery disease (CAD). Technology is improv...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2010.02.011
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To evaluate deep-learning based calcium quantification on Chest CT scans compared with manual evaluation, and to enable interpretation in terms of the traditional Agatston score on dedicated Cardiac CT. METHODS:Automated calcium quantification was performed using a combination of deep-learning convolution neur...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.109428
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:Evaluation of percutaneous recanalization of obstructed iliac as well as superficial femoral arteries (SFAs) in patients with peripheral arterial obstructive disease (PAOD). MATERIAL AND METHODS:The data of 195 consecutive patients with 285 obstructions of the common and or external iliac artery as well as the...
journal_title:European journal of radiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ejrad.2010.04.016
更新日期:2010-07-01 00:00:00
abstract::Recent years have brought rapid developments in computational image analysis in musculo-skeletal radiology. Meanwhile the algorithms have reached a maturity that makes initial clinical use feasible. Applications range from joint space measurement to erosion quantification, and from fracture detection to the assessment...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2009.05.053
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine if there is a significant difference in the CT Hounsfield Unit (CTHU) of the carotid atherosclerotic plaque (CAP) on CTpre and CTartery depending on the presence of symptomatology. METHODS:Quantitative analysis of the CTHUs for the CAP was performed in 43 arteries (11...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.06.029
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To define National Diagnostic Reference Levels (NDRLs) for computed tomography (CT) for Austria on adult patients. METHOD:In the course of a nationwide survey on common CT-examinations between June 2018 and November 2018, datasets were requested from all Austrian hospitals and radiology centers with CT-scanner...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2020.108863
更新日期:2020-04-01 00:00:00
abstract::Imaging plays an important role in the staging of nasopharyngeal carcinoma. Accurate staging is necessary, as the treatment is directly dependent on stage. Clinical examination provides information on mucosal involvement but is unable to determine the deep extension or the presence of skull base invasion or intracrani...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2008.03.029
更新日期:2008-06-01 00:00:00
abstract::Research into the possibilities of AI in cardiac CT has been growing rapidly in the last decade. With the rise of publicly available databases and AI algorithms, many researchers and clinicians have started investigations into the use of AI in the clinical workflow. This review is a comprehensive overview on the types...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2020.108969
更新日期:2020-07-01 00:00:00
abstract::The increasing number of radiographic images is a problem in most radiology departments. The problem will be emphasized with the introduction of digital acquisition and storage of radiographs. Changes in image management strategies will therefore become necessary. Such strategies will have great technologic and financ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/0720-048x(92)90077-m
更新日期:1992-05-01 00:00:00
abstract::Renal venous DSA yields diagnostically adequate results in an unselected population in more than 85% of cases. Image quality is compromised predominantly by inadequate contrast enhancement, motion artifacts from the stomach and the bowel, and obesity. The effect of these factors increases with patient age. Selection o...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract::This is a review of the current strengths and weaknesses of the various imaging modalities available for the diagnosis of suspected non-massive Pulmonary Embolism (PE). Without careful consideration for the clinical presentation, and the timely application of clinical decision support (CDS) methodology, the current ov...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2015.03.023
更新日期:2015-06-01 00:00:00
abstract::The synthesis and the chemical characterization of iomeprol, a new triiodinated nonionic radiographic contrast agent, are reported. The physico-chemical properties both of aqueous solutions of the pure compound and of its pharmaceutical formulations are presented and these last data are compared with those of other co...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/0720-048x(94)90089-2
更新日期:1994-05-01 00:00:00
abstract::ECG-gating of a pulsed radiation exposure during end-diastole using digital subtraction angiography shows significantly better results in the examination of the aortic arch vessels and pulmonary arteries and may be expected to decrease the rate of false positive diagnosis of stenosis when examining renal arteries. Dif...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00