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Superselective cisplatin (CDDP)-carboplatin (CBDCA) combined infusion for head and neck cancers.

Abstract：

:A group of 26 patients with carcinoma of the head and neck region was treated by superselective intra-arterial infusion of cisplatin (CDDP)-carboplatin (CBDCA). The tumor locations included the tongue (n = 4), oral base (n = 2), nasopharynx (n = 2), oropharynx (n = 8), hypopharynx (n = 4) and larynx (n = 4). Using the coaxial technique, a microcatheter was placed in the lingual, ascending pharyngeal, facial and superior thyroidal arteries according to the location of the tumor. Under imaging studies, CDDP (50 mg/m2)-CBDCA (300 mg/m2) was infused into the vessel, via injectors at the rate of 12.5 ml/min. One to five injections were given every 4 weeks. During and following the chemotherapy the patients received radiotherapy (n = 22), surgery (n = 4) or both (n = 3). Sixty-six sessions of intra-arterial chemotherapy were given with no major complications. Drug-related systemic side effects were mild. The overall response rate was 96% (complete response (CR) 50% and partial response (PR) 46%). Superselective CDDP-CBDCA combined infusion is feasible, relatively non-toxic, and important as multimodality therapy.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Imai S,Kajihara Y,Munemori O,Kamei T,Mori T,Handa T,Akisada K,Orita Y

doi

10.1016/0720-048x(95)00692-j

subject

Has Abstract

pub_date

1995-12-15 00:00:00

pages

94-9

issue

2

eissn

0720-048X

issn

1872-7727

pii

0720048X9500692J

journal_volume

21

pub_type

杂志文章

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