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Quantitative MRI in post-operative paediatric cerebellar mutism syndrome.

Abstract：

:Post-operative paediatric cerebellar mutism syndrome (pCMS) occurs in around 25% of children undergoing surgery for cerebellar and fourth ventricular tumours. Reversible mutism is the hallmark of a syndrome which comprises severe motor, cognitive and linguistic deficits. Recent evidence from advanced neuroimaging studies has led to the current theoretical understanding of the condition as a form of diaschisis contingent on damage to efferent cerebellar circuitry. Tractography data derived from diffusion MRI studies have shown disruption of the dentato-rubro-thalamo-cortical tract in patients with pCMS, and perfusion studies have indicated widespread supratentorial regions which may give rise to the florid signs and symptoms of pCMS. Given the difficulties in predicting pCMS from standard structural MRI, this review discusses findings from quantitative MRI modalities which have contributed to our understanding of this debilitating syndrome, and considers the goals and challenges which lie ahead in the field.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Toescu SM,Hales PW,Aquilina K,Clark CA

doi

10.1016/j.ejrad.2018.09.007

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

43-51

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(18)30313-9

journal_volume

108

pub_type

杂志文章,评审

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